Stefano Severi
Stefano Severi
Associate Professor, Bioengineering, University of Bologna
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Patients with complex arrhythmias during and after haemodialysis suffer from different regimens of potassium removal
A Santoro, E Mancini, G London, L Mercadal, H Fessy, B Perrone, ...
Nephrology Dialysis Transplantation 23 (4), 1415-1421, 2008
An updated computational model of rabbit sinoatrial action potential to investigate the mechanisms of heart rate modulation
S Severi, M Fantini, LA Charawi, D DiFrancesco
The Journal of physiology 590 (18), 4483-4499, 2012
Computational models of ventricular-and atrial-like human induced pluripotent stem cell derived cardiomyocytes
M Paci, J Hyttinen, K Aalto-Setälä, S Severi
Annals of biomedical engineering 41 (11), 2334-2348, 2013
Elucidating arrhythmogenic mechanisms of long-QT syndrome CALM1-F142L mutation in patient-specific induced pluripotent stem cell-derived cardiomyocytes
M Rocchetti, L Sala, L Dreizehnter, L Crotti, D Sinnecker, M Mura, ...
Cardiovascular Research 113 (5), 531-541, 2017
Simulation of Ca-calmodulin-dependent protein kinase II on rabbit ventricular myocyte ion currents and action potentials
E Grandi, JL Puglisi, S Wagner, LS Maier, S Severi, DM Bers
Biophysical journal 93 (11), 3835-3847, 2007
Computational analysis of the human sinus node action potential: model development and effects of mutations
A Fabbri, M Fantini, R Wilders, S Severi
The Journal of physiology 595 (7), 2365-2396, 2017
Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy
E Passini, A Mincholé, R Coppini, E Cerbai, B Rodriguez, S Severi, ...
Journal of molecular and cellular cardiology 96, 72-81, 2016
Calcium and potassium changes during haemodialysis alter ventricular repolarization duration: in vivo and in silico analysis
S Severi, E Grandi, C Pes, F Badiali, F Grandi, A Santoro
Nephrology Dialysis Transplantation 23 (4), 1378-1386, 2008
Trafficking Defects and Gating Abnormalities of a Novel SCN5A Mutation Question Gene-Specific Therapy in Long QT Syndrome Type 3
Y Ruan, M Denegri, N Liu, T Bachetti, M Seregni, S Morotti, S Severi, ...
Circulation research 106 (8), 1374-1383, 2010
Development, calibration, and validation of a novel human ventricular myocyte model in health, disease, and drug block
J Tomek, A Bueno-Orovio, E Passini, X Zhou, A Minchole, O Britton, ...
Elife 8, 2019
Autonomic nervous function during haemodialysis assessed by spectral analysis of heart-rate variability
S Cavalcanti, S Severi, L Chiari, G Avanzolini, G Enzmann, F Bianco, ...
Clinical science 92 (4), 351-359, 1997
Human induced pluripotent stem cell‐derived versus adult cardiomyocytes: an in silico electrophysiological study on effects of ionic current block
M Paci, J Hyttinen, B Rodriguez, S Severi
British journal of pharmacology 172 (21), 5147-5160, 2015
A Brugada syndrome mutation (p. S216L) and its modulation by p. H558R polymorphism: standard and dynamic characterization
S Marangoni, C Di Resta, M Rocchetti, L Barile, R Rizzetto, A Summa, ...
Cardiovascular research 91 (4), 606-616, 2011
Automatic Optimization of an in Silico Model of Human iPSC Derived Cardiomyocytes Recapitulating Calcium Handling Abnormalities
M Paci, RP Pölönen, D Cori, K Penttinen, K Aalto-Setälä, S Severi, ...
Frontiers in physiology 9, 709, 2018
A new KCNQ1 mutation at the S5 segment that impairs its association with KCNE1 is responsible for short QT syndrome
C Moreno, A Oliveras, A de la Cruz, C Bartolucci, C Munoz, E Salar, ...
Cardiovascular Research 107 (4), 613-623, 2015
Non-binary coding for texture descriptors in sub-cellular and stem cell image classification
M Paci, L Nanni, A Lahti, K Aalto-Setala, J Hyttinen, S Severi
Current Bioinformatics 8 (2), 208-219, 2013
General Principles for the Validation of Proarrhythmia Risk Prediction Models: An Extension of the CiPA In Silico Strategy
Z Li, GR Mirams, T Yoshinaga, BJ Ridder, X Han, JE Chen, ...
Clinical Pharmacology & Therapeutics 107 (1), 102-111, 2020
Theoretical investigation of action potential duration dependence on extracellular Ca2+ in human cardiomyocytes
E Grandi, FS Pasqualini, C Pes, C Corsi, A Zaza, S Severi
Journal of Molecular and Cellular Cardiology 46 (3), 332-342, 2009
Alterations of atrial electrophysiology induced by electrolyte variations: combined computational and P-wave analysis
S Severi, D Pogliani, G Fantini, P Fabbrini, MR Vigano, E Galbiati, ...
Europace 12 (6), 842-849, 2010
Phenotypic variability in LQT3 human induced pluripotent stem cell-derived cardiomyocytes and their response to antiarrhythmic pharmacologic therapy: an in silico approach
M Paci, E Passini, S Severi, J Hyttinen, B Rodriguez
Heart Rhythm 14 (11), 1704-1712, 2017
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