| The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1-to S-phase transition S Meloche, J Pouysségur Oncogene 26 (22), 3227-3239, 2007 | 1359 | 2007 |
| Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation. G Pages, P Lenormand, G L'Allemain, JC Chambard, S Meloche, ... Proceedings of the National Academy of Sciences 90 (18), 8319-8323, 1993 | 1285 | 1993 |
| FGF stimulation of the Erk1/2 signalling cascade triggers transition of pluripotent embryonic stem cells from self-renewal to lineage commitment T Kunath, MK Saba-El-Leil, M Almousailleakh, J Wray, S Meloche, ... Oxford University Press for The Company of Biologists Limited 134 (16), 2895 …, 2007 | 940 | 2007 |
| An essential function of the mitogen‐activated protein kinase Erk2 in mouse trophoblast development MK Saba‐El‐Leil, FDJ Vella, B Vernay, L Voisin, L Chen, N Labrecque, ... EMBO reports 4 (10), 964-968, 2003 | 469 | 2003 |
| Roles of the Candida albicansMitogen-Activated Protein Kinase Homolog, Cek1p, in Hyphal Development and Systemic Candidiasis C Csank, K Schröppel, E Leberer, D Harcus, O Mohamed, S Meloche, ... Infection and immunity 66 (6), 2713-2721, 1998 | 447 | 1998 |
| Atypical mitogen-activated protein kinases: structure, regulation and functions P Coulombe, S Meloche Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1773 (8), 1376-1387, 2007 | 436 | 2007 |
| Biphasic and synergistic activation of p44mapk (ERK1) by growth factors: correlation between late phase activation and mitogenicity. S Meloche, K Seuwen, G Pages, J Pouyssegur Molecular Endocrinology 6 (5), 845-854, 1992 | 376 | 1992 |
| p27 cytoplasmic localization is regulated by phosphorylation on Ser10 and is not a prerequisite for its proteolysis G Rodier, A Montagnoli, L Di Marcotullio, P Coulombe, GF Draetta, ... The EMBO journal, 2001 | 346 | 2001 |
| Heregulin selectively upregulates vascular endothelial growth factor secretion in cancer cells and stimulates angiogenesis L Yen, XL You, AE Al Moustafa, G Batist, NE Hynes, S Mader, S Meloche, ... Oncogene 19 (31), 3460-3469, 2000 | 321 | 2000 |
| Tissue-specific GATA factors are transcriptional effectors of the small GTPase RhoA F Charron, G Tsimiklis, M Arcand, L Robitaille, Q Liang, JD Molkentin, ... Genes & development 15 (20), 2702-2719, 2001 | 313 | 2001 |
| Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo NH Purcell, BJ Wilkins, A York, MK Saba-El-Leil, S Meloche, J Robbins, ... Proceedings of the National Academy of Sciences 104 (35), 14074-14079, 2007 | 301 | 2007 |
| Coordinate, biphasic activation of p44 mitogen-activated protein kinase and S6 kinase by growth factors in hamster fibroblasts. Evidence for thrombin-induced signals different … C Kahan, K Seuwen, S Meloche, J Pouyssegur Journal of Biological Chemistry 267 (19), 13369-13375, 1992 | 297 | 1992 |
| From basic research to clinical development of MEK1/2 inhibitors for cancer therapy C Frémin, S Meloche Journal of hematology & oncology 3, 1-11, 2010 | 294 | 2010 |
| MEK1-ERK2 signaling pathway protects myocardium from ischemic injury in vivo DJ Lips, OF Bueno, BJ Wilkins, NH Purcell, RA Kaiser, JN Lorenz, ... Circulation 109 (16), 1938-1941, 2004 | 293 | 2004 |
| Extracellular signal-regulated kinases 1 and 2 regulate the balance between eccentric and concentric cardiac growth I Kehat, J Davis, M Tiburcy, F Accornero, MK Saba-El-Leil, M Maillet, ... Circulation research 108 (2), 176-183, 2011 | 288 | 2011 |
| Phosphorylation of IκBα in the C-terminal PEST domain by casein kinase II affects intrinsic protein stability R Lin, P Beauparlant, C Makris, S Meloche, J Hiscott Molecular and Cellular Biology, 1996 | 265 | 1996 |
| ERKs in cancer: friends or foes? X Deschênes-Simard, F Kottakis, S Meloche, G Ferbeyre Cancer research 74 (2), 412-419, 2014 | 249 | 2014 |
| An allosteric inhibitor of the human Cdc34 ubiquitin-conjugating enzyme DF Ceccarelli, X Tang, B Pelletier, S Orlicky, W Xie, V Plantevin, ... Cell 145 (7), 1075-1087, 2011 | 247 | 2011 |
| The IKK-related kinases: from innate immunity to oncogenesis JF Clément, S Meloche, MJ Servant Cell research 18 (9), 889-899, 2008 | 230 | 2008 |
| Dual regulation of MMP-2 expression by the type 1 insulin-like growth factor receptor: the phosphatidylinositol 3-kinase/Akt and Raf/ERK pathways transmit opposing signals D Zhang, M Bar-Eli, S Meloche, P Brodt Journal of Biological Chemistry 279 (19), 19683-19690, 2004 | 223 | 2004 |
