Seuraa
Peppi Koivunen
Peppi Koivunen
Faculty of Medical Biochemistry and Molecular Biology, University of Oulu
Vahvistettu sähköpostiosoite verkkotunnuksessa oulu.fi
Nimike
Viittaukset
Viittaukset
Vuosi
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
M Hirsila, P Koivunen, V Gunzler, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 278 (33), 30772-30780, 2003
9632003
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
P Koivunen, S Lee, CG Duncan, G Lopez, G Lu, S Ramkissoon, ...
Nature 483 (7390), 484-488, 2012
8082012
(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
JA Losman, RE Looper, P Koivunen, S Lee, RK Schneider, C McMahon, ...
Science 339 (6127), 1621-1625, 2013
7602013
Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
P Koivunen, M Hirsilä, AM Remes, IE Hassinen, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 282 (7), 4524-4532, 2007
6262007
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
P Koivunen, M Hirsilä, V Günzler, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 279 (11), 9899-9904, 2004
5322004
A genetic mechanism for Tibetan high-altitude adaptation
FR Lorenzo, C Huff, M Myllymäki, B Olenchock, S Swierczek, T Tashi, ...
Nature genetics 46 (9), 951-956, 2014
4192014
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
AA Chakraborty, T Laukka, M Myllykoski, AE Ringel, MA Booker, ...
Science 363 (6432), 1217-1222, 2019
3292019
Fumarate and succinate regulate expression of hypoxia-inducible genes via TET enzymes
T Laukka, CJ Mariani, T Ihantola, JZ Cao, J Hokkanen, WG Kaelin, ...
Journal of Biological Chemistry 291 (8), 4256-4265, 2016
3002016
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway
M Hirsilä, P Koivunen, L Xu, T Seeley, KI Kivirikko, J Myllyharju
The FASEB Journal 19 (10), 1308-1310, 2005
2662005
Paracrine induction of HIF by glutamate in breast cancer: EglN1 senses cysteine
KJ Briggs, P Koivunen, S Cao, KM Backus, BA Olenchock, H Patel, ...
Cell 166 (1), 126-139, 2016
1912016
The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer
E Peurala, P Koivunen, KM Haapasaari, R Bloigu, A Jukkola-Vuorinen
Breast Cancer Research 15 (1), 1-10, 2013
1762013
An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor α
P Koivunen, P Tiainen, J Hyvärinen, KE Williams, R Sormunen, ...
Journal of Biological Chemistry 282 (42), 30544-30552, 2007
1732007
The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases
P Koivunen, M Hirsilä, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 281 (39), 28712-28720, 2006
1612006
HIF-1α is upregulated in human mesenchymal stem cells
S Palomäki, M Pietilä, S Laitinen, J Pesälä, R Sormunen, P Lehenkari, ...
Stem cells 31 (9), 1902-1909, 2013
1432013
2-Oxoglutarate-dependent dioxygenases in cancer
JA Losman, P Koivunen, WG Kaelin Jr
Nature Reviews Cancer 20 (12), 710-726, 2020
1392020
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase
X Zheng, B Zhai, P Koivunen, SJ Shin, G Lu, J Liu, C Geisen, ...
Genes & development 28 (13), 1429-1444, 2014
1332014
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury
J Hyvärinen, IE Hassinen, R Sormunen, JM Mäki, KI Kivirikko, P Koivunen, ...
Journal of Biological Chemistry 285 (18), 13646-13657, 2010
1312010
HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction
L Rahtu-Korpela, S Karsikas, S Hörkkö, R Blanco Sequeiros, ...
Diabetes 63 (10), 3324-3333, 2014
1212014
Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity
P Tiainen, J Myllyharju, P Koivunen
Journal of Biological Chemistry 280 (2), 1142-1148, 2005
1212005
The primary substrate binding site in the b′ domain of ERp57 is adapted for endoplasmic reticulum lectin association
SJ Russell, LW Ruddock, KEH Salo, JD Oliver, QP Roebuck, ...
Journal of Biological Chemistry 279 (18), 18861-18869, 2004
1192004
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Artikkelit 1–20