Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor M Hirsila, P Koivunen, V Gunzler, KI Kivirikko, J Myllyharju Journal of Biological Chemistry 278 (33), 30772-30780, 2003 | 1007 | 2003 |
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation P Koivunen, S Lee, CG Duncan, G Lopez, G Lu, S Ramkissoon, ... Nature 483 (7390), 484-488, 2012 | 865 | 2012 |
(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible JA Losman, RE Looper, P Koivunen, S Lee, RK Schneider, C McMahon, ... Science 339 (6127), 1621-1625, 2013 | 806 | 2013 |
Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF P Koivunen, M Hirsilä, AM Remes, IE Hassinen, KI Kivirikko, J Myllyharju Journal of Biological Chemistry 282 (7), 4524-4532, 2007 | 659 | 2007 |
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases P Koivunen, M Hirsilä, V Günzler, KI Kivirikko, J Myllyharju Journal of Biological Chemistry 279 (11), 9899-9904, 2004 | 562 | 2004 |
A genetic mechanism for Tibetan high-altitude adaptation FR Lorenzo, C Huff, M Myllymäki, B Olenchock, S Swierczek, T Tashi, ... Nature genetics 46 (9), 951-956, 2014 | 445 | 2014 |
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate AA Chakraborty, T Laukka, M Myllykoski, AE Ringel, MA Booker, ... Science 363 (6432), 1217-1222, 2019 | 390 | 2019 |
Fumarate and succinate regulate expression of hypoxia-inducible genes via TET enzymes T Laukka, CJ Mariani, T Ihantola, JZ Cao, J Hokkanen, WG Kaelin, ... Journal of Biological Chemistry 291 (8), 4256-4265, 2016 | 338 | 2016 |
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway M Hirsilä, P Koivunen, L Xu, T Seeley, KI Kivirikko, J Myllyharju The FASEB Journal 19 (10), 1308-1310, 2005 | 280 | 2005 |
Paracrine induction of HIF by glutamate in breast cancer: EglN1 senses cysteine KJ Briggs, P Koivunen, S Cao, KM Backus, BA Olenchock, H Patel, ... Cell 166 (1), 126-139, 2016 | 223 | 2016 |
The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer E Peurala, P Koivunen, KM Haapasaari, R Bloigu, A Jukkola-Vuorinen Breast Cancer Research 15, 1-10, 2013 | 199 | 2013 |
2-Oxoglutarate-dependent dioxygenases in cancer JA Losman, P Koivunen, WG Kaelin Jr Nature Reviews Cancer 20 (12), 710-726, 2020 | 192 | 2020 |
An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor α P Koivunen, P Tiainen, J Hyvärinen, KE Williams, R Sormunen, ... Journal of Biological Chemistry 282 (42), 30544-30552, 2007 | 183 | 2007 |
The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases P Koivunen, M Hirsilä, KI Kivirikko, J Myllyharju Journal of Biological Chemistry 281 (39), 28712-28720, 2006 | 164 | 2006 |
HIF-1α is upregulated in human mesenchymal stem cells S Palomäki, M Pietilä, S Laitinen, J Pesälä, R Sormunen, P Lehenkari, ... Stem cells 31 (9), 1902-1909, 2013 | 151 | 2013 |
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase X Zheng, B Zhai, P Koivunen, SJ Shin, G Lu, J Liu, C Geisen, ... Genes & development 28 (13), 1429-1444, 2014 | 141 | 2014 |
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury J Hyvärinen, IE Hassinen, R Sormunen, JM Mäki, KI Kivirikko, P Koivunen, ... Journal of Biological Chemistry 285 (18), 13646-13657, 2010 | 136 | 2010 |
HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction L Rahtu-Korpela, S Karsikas, S Hörkkö, R Blanco Sequeiros, ... Diabetes 63 (10), 3324-3333, 2014 | 132 | 2014 |
Ferritin-mediated iron sequestration stabilizes hypoxia-inducible factor-1α upon LPS activation in the presence of ample oxygen I Siegert, J Schödel, M Nairz, V Schatz, K Dettmer, C Dick, J Kalucka, ... Cell reports 13 (10), 2048-2055, 2015 | 124 | 2015 |
Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity P Tiainen, J Myllyharju, P Koivunen Journal of Biological Chemistry 280 (2), 1142-1148, 2005 | 124 | 2005 |