|Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor|
M Hirsila, P Koivunen, V Gunzler, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 278 (33), 30772-30780, 2003
|Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation|
P Koivunen, S Lee, CG Duncan, G Lopez, G Lu, S Ramkissoon, ...
Nature 483 (7390), 484-488, 2012
|(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible|
JA Losman, RE Looper, P Koivunen, S Lee, RK Schneider, C McMahon, ...
Science 339 (6127), 1621-1625, 2013
|Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF|
P Koivunen, M Hirsilä, AM Remes, IE Hassinen, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 282 (7), 4524-4532, 2007
|Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases|
P Koivunen, M Hirsilä, V Günzler, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 279 (11), 9899-9904, 2004
|A genetic mechanism for Tibetan high-altitude adaptation|
FR Lorenzo, C Huff, M Myllymäki, B Olenchock, S Swierczek, T Tashi, ...
Nature genetics 46 (9), 951-956, 2014
|Fumarate and succinate regulate expression of hypoxia-inducible genes via TET enzymes|
T Laukka, CJ Mariani, T Ihantola, JZ Cao, J Hokkanen, WG Kaelin, ...
Journal of Biological Chemistry 291 (8), 4256-4265, 2016
|Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway|
M Hirsilä, P Koivunen, L Xu, T Seeley, KI Kivirikko, J Myllyharju
The FASEB Journal 19 (10), 1308-1310, 2005
|Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate|
AA Chakraborty, T Laukka, M Myllykoski, AE Ringel, MA Booker, ...
Science 363 (6432), 1217-1222, 2019
|Paracrine induction of HIF by glutamate in breast cancer: EglN1 senses cysteine|
KJ Briggs, P Koivunen, S Cao, KM Backus, BA Olenchock, H Patel, ...
Cell 166 (1), 126-139, 2016
|An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor α|
P Koivunen, P Tiainen, J Hyvärinen, KE Williams, R Sormunen, ...
Journal of Biological Chemistry 282 (42), 30544-30552, 2007
|The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer|
E Peurala, P Koivunen, KM Haapasaari, R Bloigu, A Jukkola-Vuorinen
Breast Cancer Research 15 (1), 1-10, 2013
|The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases|
P Koivunen, M Hirsilä, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 281 (39), 28712-28720, 2006
|HIF-1α is upregulated in human mesenchymal stem cells|
S Palomäki, M Pietilä, S Laitinen, J Pesälä, R Sormunen, P Lehenkari, ...
Stem cells 31 (9), 1902-1909, 2013
|Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury|
J Hyvärinen, IE Hassinen, R Sormunen, JM Mäki, KI Kivirikko, P Koivunen, ...
Journal of Biological Chemistry 285 (18), 13646-13657, 2010
|Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase|
X Zheng, B Zhai, P Koivunen, SJ Shin, G Lu, J Liu, C Geisen, ...
Genes & development 28 (13), 1429-1444, 2014
|Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity|
P Tiainen, J Myllyharju, P Koivunen
Journal of Biological Chemistry 280 (2), 1142-1148, 2005
|The primary substrate binding site in the b′ domain of ERp57 is adapted for endoplasmic reticulum lectin association|
SJ Russell, LW Ruddock, KEH Salo, JD Oliver, QP Roebuck, ...
Journal of Biological Chemistry 279 (18), 18861-18869, 2004
|Hypoxia-inducible factor prolyl 4-hydroxylases: common and specific roles|
J Myllyharju, P Koivunen
Biological chemistry 394 (4), 435-448, 2013
|HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction|
L Rahtu-Korpela, S Karsikas, S Hörkkö, R Blanco Sequeiros, ...
Diabetes 63 (10), 3324-3333, 2014