Seuraa
Peppi Koivunen
Peppi Koivunen
Faculty of Medical Biochemistry and Molecular Biology, University of Oulu
Vahvistettu sähköpostiosoite verkkotunnuksessa oulu.fi
Nimike
Viittaukset
Viittaukset
Vuosi
Characterization of the human prolyl 4-hydroxylases that modify the hypoxia-inducible factor
M Hirsila, P Koivunen, V Gunzler, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 278 (33), 30772-30780, 2003
10072003
Transformation by the (R)-enantiomer of 2-hydroxyglutarate linked to EGLN activation
P Koivunen, S Lee, CG Duncan, G Lopez, G Lu, S Ramkissoon, ...
Nature 483 (7390), 484-488, 2012
8652012
(R)-2-Hydroxyglutarate Is Sufficient to Promote Leukemogenesis and Its Effects Are Reversible
JA Losman, RE Looper, P Koivunen, S Lee, RK Schneider, C McMahon, ...
Science 339 (6127), 1621-1625, 2013
8062013
Inhibition of hypoxia-inducible factor (HIF) hydroxylases by citric acid cycle intermediates: possible links between cell metabolism and stabilization of HIF
P Koivunen, M Hirsilä, AM Remes, IE Hassinen, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 282 (7), 4524-4532, 2007
6592007
Catalytic properties of the asparaginyl hydroxylase (FIH) in the oxygen sensing pathway are distinct from those of its prolyl 4-hydroxylases
P Koivunen, M Hirsilä, V Günzler, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 279 (11), 9899-9904, 2004
5622004
A genetic mechanism for Tibetan high-altitude adaptation
FR Lorenzo, C Huff, M Myllymäki, B Olenchock, S Swierczek, T Tashi, ...
Nature genetics 46 (9), 951-956, 2014
4452014
Histone demethylase KDM6A directly senses oxygen to control chromatin and cell fate
AA Chakraborty, T Laukka, M Myllykoski, AE Ringel, MA Booker, ...
Science 363 (6432), 1217-1222, 2019
3902019
Fumarate and succinate regulate expression of hypoxia-inducible genes via TET enzymes
T Laukka, CJ Mariani, T Ihantola, JZ Cao, J Hokkanen, WG Kaelin, ...
Journal of Biological Chemistry 291 (8), 4256-4265, 2016
3382016
Effect of desferrioxamine and metals on the hydroxylases in the oxygen sensing pathway
M Hirsilä, P Koivunen, L Xu, T Seeley, KI Kivirikko, J Myllyharju
The FASEB Journal 19 (10), 1308-1310, 2005
2802005
Paracrine induction of HIF by glutamate in breast cancer: EglN1 senses cysteine
KJ Briggs, P Koivunen, S Cao, KM Backus, BA Olenchock, H Patel, ...
Cell 166 (1), 126-139, 2016
2232016
The prognostic significance and value of cyclin D1, CDK4 and p16 in human breast cancer
E Peurala, P Koivunen, KM Haapasaari, R Bloigu, A Jukkola-Vuorinen
Breast Cancer Research 15, 1-10, 2013
1992013
2-Oxoglutarate-dependent dioxygenases in cancer
JA Losman, P Koivunen, WG Kaelin Jr
Nature Reviews Cancer 20 (12), 710-726, 2020
1922020
An endoplasmic reticulum transmembrane prolyl 4-hydroxylase is induced by hypoxia and acts on hypoxia-inducible factor α
P Koivunen, P Tiainen, J Hyvärinen, KE Williams, R Sormunen, ...
Journal of Biological Chemistry 282 (42), 30544-30552, 2007
1832007
The length of peptide substrates has a marked effect on hydroxylation by the hypoxia-inducible factor prolyl 4-hydroxylases
P Koivunen, M Hirsilä, KI Kivirikko, J Myllyharju
Journal of Biological Chemistry 281 (39), 28712-28720, 2006
1642006
HIF-1α is upregulated in human mesenchymal stem cells
S Palomäki, M Pietilä, S Laitinen, J Pesälä, R Sormunen, P Lehenkari, ...
Stem cells 31 (9), 1902-1909, 2013
1512013
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase
X Zheng, B Zhai, P Koivunen, SJ Shin, G Lu, J Liu, C Geisen, ...
Genes & development 28 (13), 1429-1444, 2014
1412014
Hearts of hypoxia-inducible factor prolyl 4-hydroxylase-2 hypomorphic mice show protection against acute ischemia-reperfusion injury
J Hyvärinen, IE Hassinen, R Sormunen, JM Mäki, KI Kivirikko, P Koivunen, ...
Journal of Biological Chemistry 285 (18), 13646-13657, 2010
1362010
HIF prolyl 4-hydroxylase-2 inhibition improves glucose and lipid metabolism and protects against obesity and metabolic dysfunction
L Rahtu-Korpela, S Karsikas, S Hörkkö, R Blanco Sequeiros, ...
Diabetes 63 (10), 3324-3333, 2014
1322014
Ferritin-mediated iron sequestration stabilizes hypoxia-inducible factor-1α upon LPS activation in the presence of ample oxygen
I Siegert, J Schödel, M Nairz, V Schatz, K Dettmer, C Dick, J Kalucka, ...
Cell reports 13 (10), 2048-2055, 2015
1242015
Characterization of a second Arabidopsis thaliana prolyl 4-hydroxylase with distinct substrate specificity
P Tiainen, J Myllyharju, P Koivunen
Journal of Biological Chemistry 280 (2), 1142-1148, 2005
1242005
Järjestelmä ei voi suorittaa toimenpidettä nyt. Yritä myöhemmin uudelleen.
Artikkelit 1–20