| Guidelines for the use and interpretation of assays for monitoring autophagy DJ Klionsky, FC Abdalla, H Abeliovich, RT Abraham, A Acevedo-Arozena, ... Autophagy 8 (4), 445-544, 2012 | 13254* | 2012 |
| β-sheet breaker peptides inhibit fibrillogenesis in a rat brain model of amyloidosis: implications for Alzheimer's therapy C Soto, EM Sigurdsson, L Morelli, R Asok Kumar, EM Castaño, ... Nature medicine 4 (7), 822-826, 1998 | 1106 | 1998 |
| Tau-targeting therapies for Alzheimer disease EE Congdon, EM Sigurdsson Nature Reviews Neurology 14 (7), 399-415, 2018 | 948 | 2018 |
| Immunotherapy targeting pathological tau conformers in a tangle mouse model reduces brain pathology with associated functional improvements AA Asuni, A Boutajangout, D Quartermain, EM Sigurdsson Journal of Neuroscience 27 (34), 9115-9129, 2007 | 609 | 2007 |
| Passive immunization targeting pathological phospho‐tau protein in a mouse model reduces functional decline and clears tau aggregates from the brain A Boutajangout, J Ingadottir, P Davies, EM Sigurdsson Journal of neurochemistry 118 (4), 658-667, 2011 | 380 | 2011 |
| Immunization with a nontoxic/nonfibrillar amyloid-β homologous peptide reduces Alzheimer's disease-associated pathology in transgenic mice EM Sigurdsson, H Scholtzova, PD Mehta, B Frangione, T Wisniewski The American journal of pathology 159 (2), 439-447, 2001 | 355 | 2001 |
| Immunotherapy targeting pathological tau prevents cognitive decline in a new tangle mouse model A Boutajangout, D Quartermain, EM Sigurdsson Journal of Neuroscience 30 (49), 16559-16566, 2010 | 347 | 2010 |
| Detection of Alzheimer's amyloid in transgenic mice using magnetic resonance microimaging YZ Wadghiri, EM Sigurdsson, M Sadowski, JI Elliott, Y Li, H Scholtzova, ... Magnetic Resonance in Medicine: An Official Journal of the International …, 2003 | 343 | 2003 |
| Tau immunotherapy for Alzheimer's disease JT Pedersen, EM Sigurdsson Trends in molecular medicine 21 (6), 394-402, 2015 | 293 | 2015 |
| Molecular targeting of Alzheimer's amyloid plaques for contrast-enhanced magnetic resonance imaging JF Poduslo, TM Wengenack, GL Curran, T Wisniewski, EM Sigurdsson, ... Neurobiology of disease 11 (2), 315-329, 2002 | 283 | 2002 |
| Extracellular tau oligomers produce an immediate impairment of LTP and memory M Fá, D Puzzo, R Piacentini, A Staniszewski, H Zhang, MA Baltrons, ... Scientific reports 6 (1), 19393, 2016 | 264 | 2016 |
| Immunization delays the onset of prion disease in mice EM Sigurdsson, DR Brown, M Daniels, RJ Kascsak, R Kascsak, R Carp, ... The American journal of pathology 161 (1), 13-17, 2002 | 248 | 2002 |
| Copper chelation delays the onset of prion disease EM Sigurdsson, DR Brown, MA Alim, H Scholtzova, R Carp, HC Meeker, ... Journal of Biological Chemistry 278 (47), 46199-46202, 2003 | 243 | 2003 |
| Antibody uptake into neurons occurs primarily via clathrin-dependent Fcγ receptor endocytosis and is a prerequisite for acute tau protein clearance EE Congdon, J Gu, HBR Sait, EM Sigurdsson Journal of Biological Chemistry 288 (49), 35452-35465, 2013 | 204 | 2013 |
| Two novel Tau antibodies targeting the 396/404 region are primarily taken up by neurons and reduce Tau protein pathology J Gu, EE Congdon, EM Sigurdsson Journal of Biological Chemistry 288 (46), 33081-33095, 2013 | 191 | 2013 |
| An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-β derivatives EM Sigurdsson, E Knudsen, A Asuni, C Fitzer-Attas, D Sage, ... Journal of Neuroscience 24 (28), 6277-6282, 2004 | 191 | 2004 |
| An attenuated immune response is sufficient to enhance cognition in an Alzheimer's disease mouse model immunized with amyloid-β derivatives EM Sigurdsson, E Knudsen, A Asuni, C Fitzer-Attas, D Sage, ... Journal of Neuroscience 24 (28), 6277-6282, 2004 | 191 | 2004 |
| Postsynaptic degeneration as revealed by PSD-95 reduction occurs after advanced Aβ and tau pathology in transgenic mouse models of Alzheimer’s disease CY Shao, SS Mirra, HBR Sait, TC Sacktor, EM Sigurdsson Acta neuropathologica 122, 285-292, 2011 | 187 | 2011 |
| A synthetic peptide blocking the apolipoprotein E/β-amyloid binding mitigates β-amyloid toxicity and fibril formation in vitro and reduces β-amyloid plaques in transgenic mice M Sadowski, J Pankiewicz, H Scholtzova, JA Ripellino, Y Li, SD Schmidt, ... The American journal of pathology 165 (3), 937-948, 2004 | 175 | 2004 |
| Immunotherapy targeting pathological tau protein in Alzheimer's disease and related tauopathies EM Sigurdsson journal of Alzheimer's Disease 15 (2), 157-168, 2008 | 167 | 2008 |
Thomas WisniewskiProfessor of Neurology, Pathology and Psychiatry, New York University School of MedicineVerified email at nyulangone.org
