Discovery of taniborbactam (VNRX-5133): a broad-spectrum serine-and metallo-β-lactamase inhibitor for carbapenem-resistant bacterial infections B Liu, REL Trout, GH Chu, D McGarry, RW Jackson, JC Hamrick, ... Journal of Medicinal Chemistry 63 (6), 2789-2801, 2019 | 228 | 2019 |
VNRX-5133 (Taniborbactam), a Broad-Spectrum Inhibitor of Serine- and Metallo-β-Lactamases, Restores Activity of Cefepime in Enterobacterales and … JC Hamrick, JD Docquier, T Uehara, CL Myers, DA Six, CL Chatwin, ... Antimicrobial Agents and Chemotherapy 64 (3), 10.1128/aac. 01963-19, 2020 | 155 | 2020 |
Structural insights into the ferroxidase site of ferritins from higher eukaryotes I Bertini, D Lalli, S Mangani, C Pozzi, C Rosa, EC Theil, P Turano Journal of the American Chemical Society 134 (14), 6169-6176, 2012 | 109 | 2012 |
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase D Cardinale, G Guaitoli, D Tondi, R Luciani, S Henrich, OMH Salo-Ahen, ... Proceedings of the National Academy of Sciences 108 (34), E542-E549, 2011 | 104 | 2011 |
Iron binding to human heavy-chain ferritin C Pozzi, F Di Pisa, C Bernacchioni, S Ciambellotti, P Turano, S Mangani Acta Crystallographica Section D: Biological Crystallography 71 (9), 1909-1920, 2015 | 78 | 2015 |
Chemistry at the protein–mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo) Tris [(μ2-peroxo)] triiron (III) cluster C Pozzi, S Ciambellotti, C Bernacchioni, F Di Pisa, S Mangani, P Turano Proceedings of the National Academy of Sciences 114 (10), 2580-2585, 2017 | 76 | 2017 |
Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design F De Luca, M Benvenuti, F Carboni, C Pozzi, GM Rossolini, S Mangani, ... Proceedings of the National Academy of Sciences 108 (45), 18424-18429, 2011 | 73 | 2011 |
SAR studies leading to the identification of a novel series of metallo-β-lactamase inhibitors for the treatment of carbapenem-resistant Enterobacteriaceae infections that … S Leiris, A Coelho, J Castandet, M Bayet, C Lozano, J Bougnon, ... ACS Infectious Diseases 5 (1), 131-140, 2018 | 55 | 2018 |
Time-lapse anomalous X-ray diffraction shows how Fe2+ substrate ions move through ferritin protein nanocages to oxidoreductase sites C Pozzi, F Di Pisa, D Lalli, C Rosa, E Theil, P Turano, S Mangani Acta Crystallographica Section D: Biological Crystallography 71 (4), 941-953, 2015 | 52 | 2015 |
Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs C Borsari, R Luciani, C Pozzi, I Poehner, S Henrich, M Trande, ... Journal of medicinal chemistry 59 (16), 7598-7616, 2016 | 51 | 2016 |
Chroman-4-one derivatives targeting pteridine reductase 1 and showing anti-parasitic activity F Di Pisa, G Landi, L Dello Iacono, C Pozzi, C Borsari, S Ferrari, ... Molecules 22 (3), 426, 2017 | 48 | 2017 |
Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative D Tondi, A Venturelli, R Bonnet, C Pozzi, BK Shoichet, MP Costi Journal of medicinal chemistry 57 (12), 5449-5458, 2014 | 46 | 2014 |
The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism C Pozzi, S Ferrari, D Cortesi, R Luciani, RM Stroud, A Catalano, MP Costi, ... Acta Crystallographica Section D: Biological Crystallography 68 (9), 1232-1241, 2012 | 39 | 2012 |
ANT2681: SAR studies leading to the identification of a metallo-β-lactamase inhibitor with potential for clinical use in combination with meropenem for the treatment of … DT Davies, S Leiris, N Sprynski, J Castandet, C Lozano, J Bousquet, ... ACS Infectious Diseases 6 (9), 2419-2430, 2020 | 37 | 2020 |
4-Amino-1, 2, 4-triazole-3-thione-derived Schiff bases as metallo-β-lactamase inhibitors L Gavara, L Sevaille, F De Luca, P Mercuri, C Bebrone, G Feller, A Legru, ... European Journal of Medicinal Chemistry 208, 112720, 2020 | 35 | 2020 |
Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase OMH Salo-Ahen, A Tochowicz, C Pozzi, D Cardinale, S Ferrari, Y Boum, ... Journal of medicinal chemistry 58 (8), 3572-3581, 2015 | 31 | 2015 |
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery P Linciano, A Dawson, I Pöhner, DM Costa, MS Sa, A Cordeiro-da-Silva, ... ACS omega 2 (9), 5666-5683, 2017 | 30 | 2017 |
The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders C Pozzi, F Di Pisa, M Benvenuti, S Mangani JBIC Journal of Biological Inorganic Chemistry 23, 1219-1226, 2018 | 28 | 2018 |
Enhancement of benzothiazoles as pteridine reductase-1 inhibitors for the treatment of trypanosomatidic infections P Linciano, C Pozzi, LD Iacono, F di Pisa, G Landi, A Bonucci, S Gul, ... Journal of Medicinal Chemistry 62 (8), 3989-4012, 2019 | 27 | 2019 |
Discovery of ANT3310, a Novel Broad-Spectrum Serine β-Lactamase Inhibitor of the Diazabicyclooctane Class, Which Strongly Potentiates Meropenem Activity against … DT Davies, S Leiris, M Zalacain, N Sprynski, J Castandet, J Bousquet, ... Journal of Medicinal Chemistry 63 (24), 15802-15820, 2020 | 25 | 2020 |