Cecilia Pozzi
Cecilia Pozzi
Vahvistettu sähköpostiosoite verkkotunnuksessa unisi.it
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Structural insights into the ferroxidase site of ferritins from higher eukaryotes
I Bertini, D Lalli, S Mangani, C Pozzi, C Rosa, EC Theil, P Turano
Journal of the American Chemical Society 134 (14), 6169-6176, 2012
812012
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase
D Cardinale, G Guaitoli, D Tondi, R Luciani, S Henrich, OMH Salo-Ahen, ...
Proceedings of the National Academy of Sciences 108 (34), E542-E549, 2011
662011
Evolution to carbapenem-hydrolyzing activity in noncarbapenemase class D β-lactamase OXA-10 by rational protein design
F De Luca, M Benvenuti, F Carboni, C Pozzi, GM Rossolini, S Mangani, ...
Proceedings of the National Academy of Sciences 108 (45), 18424-18429, 2011
422011
Iron binding to human heavy-chain ferritin
C Pozzi, F Di Pisa, C Bernacchioni, S Ciambellotti, P Turano, S Mangani
Acta Crystallographica Section D: Biological Crystallography 71 (9), 1909-1920, 2015
352015
Time-lapse anomalous X-ray diffraction shows how Fe2+ substrate ions move through ferritin protein nanocages to oxidoreductase sites
C Pozzi, F Di Pisa, D Lalli, C Rosa, E Theil, P Turano, S Mangani
Acta Crystallographica Section D: Biological Crystallography 71 (4), 941-953, 2015
322015
Profiling of flavonol derivatives for the development of antitrypanosomatidic drugs
C Borsari, R Luciani, C Pozzi, I Poehner, S Henrich, M Trande, ...
Journal of medicinal chemistry 59 (16), 7598-7616, 2016
302016
Targeting class A and C serine β-lactamases with a broad-spectrum boronic acid derivative
D Tondi, A Venturelli, R Bonnet, C Pozzi, BK Shoichet, MP Costi
Journal of medicinal chemistry 57 (12), 5449-5458, 2014
292014
Chemistry at the protein–mineral interface in L-ferritin assists the assembly of a functional (μ3-oxo) Tris [(μ2-peroxo)] triiron (III) cluster
C Pozzi, S Ciambellotti, C Bernacchioni, F Di Pisa, S Mangani, P Turano
Proceedings of the National Academy of Sciences 114 (10), 2580-2585, 2017
272017
Loop electrostatics modulates the intersubunit interactions in ferritin
C Bernacchioni, V Ghini, C Pozzi, F Di Pisa, EC Theil, P Turano
ACS chemical biology 9 (11), 2517-2525, 2014
212014
Hotspots in an obligate homodimeric anticancer target. Structural and functional effects of interfacial mutations in human thymidylate synthase
OMH Salo-Ahen, A Tochowicz, C Pozzi, D Cardinale, S Ferrari, Y Boum, ...
Journal of medicinal chemistry 58 (8), 3572-3581, 2015
182015
The structure of Enterococcus faecalis thymidylate synthase provides clues about folate bacterial metabolism
C Pozzi, S Ferrari, D Cortesi, R Luciani, RM Stroud, A Catalano, MP Costi, ...
Acta Crystallographica Section D: Biological Crystallography 68 (9), 1232-1241, 2012
162012
Chroman-4-One Derivatives Targeting Pteridine Reductase 1 and Showing Anti-Parasitic Activity
F Di Pisa, G Landi, L Dello Iacono, C Pozzi, C Borsari, S Ferrari, ...
Molecules 22 (3), 426, 2017
142017
Identification of the binding modes of N-phenylphthalimides inhibiting bacterial thymidylate synthase through X-ray crystallography screening
S Mangani, L Cancian, R Leone, C Pozzi, S Lazzari, R Luciani, S Ferrari, ...
Journal of medicinal chemistry 54 (15), 5454-5467, 2011
142011
Exploiting the 2-Amino-1,3,4-thiadiazole Scaffold To Inhibit Trypanosoma brucei Pteridine Reductase in Support of Early-Stage Drug Discovery
P Linciano, A Dawson, I Pöhner, DM Costa, MS Sa, A Cordeiro-da-Silva, ...
ACS omega 2 (9), 5666-5683, 2017
122017
Ferroxidase Activity in Eukaryotic Ferritin is Controlled by Accessory‐Iron‐Binding Sites in the Catalytic Cavity
C Bernacchioni, C Pozzi, F Di Pisa, S Mangani, P Turano
Chemistry–A European Journal 22 (45), 16213-16219, 2016
102016
Atomic‐Resolution Structure of a Class C β‐Lactamase and Its Complex with Avibactam
C Pozzi, F Di Pisa, F De Luca, M Benvenuti, JD Docquier, S Mangani
ChemMedChem 13 (14), 1437-1446, 2018
62018
Crystal structure of the Pseudomonas aeruginosa BEL-1 extended-spectrum β-lactamase and its complexes with moxalactam and imipenem
C Pozzi, F De Luca, M Benvenuti, L Poirel, P Nordmann, GM Rossolini, ...
Antimicrobial agents and chemotherapy 60 (12), 7189-7199, 2016
62016
The structure of the human glutaminyl cyclase–SEN177 complex indicates routes for developing new potent inhibitors as possible agents for the treatment of neurological disorders
C Pozzi, F Di Pisa, M Benvenuti, S Mangani
JBIC Journal of Biological Inorganic Chemistry 23 (8), 1219-1226, 2018
52018
In silico identification and in vitro evaluation of natural inhibitors of Leishmania major pteridine reductase I
F Herrmann, N Sivakumar, J Jose, M Costi, C Pozzi, T Schmidt
Molecules 22 (12), 2166, 2017
52017
X-ray crystal structures of Enterococcus faecalis thymidylate synthase with folate binding site inhibitors
A Catalano, R Luciani, A Carocci, D Cortesi, C Pozzi, C Borsari, S Ferrari, ...
European journal of medicinal chemistry 123, 649-664, 2016
52016
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Artikkelit 1–20