| A novel strategy for physiologically based predictions of human pharmacokinetics HM Jones, N Parrott, K Jorga, T Lavé Clinical pharmacokinetics 45, 511-542, 2006 | 392 | 2006 |
| Integration of in vitro data into allometric scaling to predict hepatic metabolic clearance in man: application to 10 extensively metabolized drugs TH Lave, S Dupin, C Schmitt, RC Chou, D Jaeck, PH Coassolo Journal of pharmaceutical sciences 86 (5), 584-590, 1997 | 223 | 1997 |
| PHRMA CPCDC initiative on predictive models of human pharmacokinetics, part 5: Prediction of plasma concentration–time profiles in human by using the physiologically‐based … P Poulin, RDO Jones, HM Jones, CR Gibson, M Rowland, JY Chien, ... Journal of pharmaceutical sciences 100 (10), 4127-4157, 2011 | 214 | 2011 |
| Prediction of Hepatic Metabolic Clearance Based on Interspecies Allometric Scaling Techniques and In Vitro-In Vivo Correlations T Lavé, P Coassolo, B Reigner Clinical pharmacokinetics 36, 211-231, 1999 | 208 | 1999 |
| PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 3: comparative assessement of prediction methods of human clearance BJ Ring, JY Chien, KK Adkison, HM Jones, M Rowland, RD Jones, ... Journal of pharmaceutical sciences 100 (10), 4090-4110, 2011 | 198 | 2011 |
| Prediction of intestinal absorption: comparative assessment of gastroplus™ and idea™ N Parrott, T Lavé European journal of pharmaceutical sciences 17 (1-2), 51-61, 2002 | 187 | 2002 |
| Predicting pharmacokinetic food effects using biorelevant solubility media and physiologically based modelling HM Jones, N Parrott, G Ohlenbusch, T Lavé Clinical pharmacokinetics 45, 1213-1226, 2006 | 161 | 2006 |
| Influence of molecular size on tissue distribution of antibody fragments Z Li, BF Krippendorff, S Sharma, AC Walz, T Lavé, DK Shah MAbs 8 (1), 113-119, 2016 | 139 | 2016 |
| The use of human hepatocytes to select compounds based on their expected hepatic extraction ratios in humans TH Lavé, S Dupin, C Schmitt, B Valles, G Ubeaud, RC Chou, D Jaeck, ... Pharmaceutical research 14, 152-155, 1997 | 139 | 1997 |
| PhRMA CPCDC initiative on predictive models of human pharmacokinetics, part 2: comparative assessment of prediction methods of human volume of distribution R Do Jones, HM Jones, M Rowland, CR Gibson, JWT Yates, JY Chien, ... Journal of pharmaceutical sciences 100 (10), 4074-4089, 2011 | 132 | 2011 |
| Applications of physiologically based absorption models in drug discovery and development N Parrott, T Lave Molecular Pharmaceutics 5 (5), 760-775, 2008 | 132 | 2008 |
| Development of a physiologically based model for oseltamivir and simulation of pharmacokinetics in neonates and infants N Parrott, B Davies, G Hoffmann, A Koerner, T Lave, E Prinssen, ... Clinical pharmacokinetics 50, 613-623, 2011 | 121 | 2011 |
| Challenges and opportunities with modelling and simulation in drug discovery and drug development T Lavé, N Parrott, HP Grimm, A Fleury, M Reddy Xenobiotica 37 (10-11), 1295-1310, 2007 | 119 | 2007 |
| Design, data analysis, and simulation of in vitro drug transport kinetic experiments using a mechanistic in vitro model A Poirier, T Lave, R Portmann, ME Brun, F Senner, M Kansy, HP Grimm, ... Drug metabolism and disposition 36 (12), 2434-2444, 2008 | 117 | 2008 |
| An evaluation of the utility of physiologically based models of pharmacokinetics in early drug discovery N Parrott, N Paquereau, P Coassolo, T Lavé Journal of pharmaceutical sciences 94 (10), 2327-2343, 2005 | 115 | 2005 |
| Prediction of hepatic metabolic clearance: comparison and assessment of prediction models J Zuegge, G Schneider, P Coassolo, T Lavé Clinical pharmacokinetics 40, 553-563, 2001 | 109 | 2001 |
| Application of full physiological models for pharmaceutical drug candidate selection and extrapolation of pharmacokinetics to man N Parrott, H Jones, N Paquereau, T Lavé Basic & clinical pharmacology & toxicology 96 (3), 193-199, 2005 | 105 | 2005 |
| Ethyl methanesulfonate toxicity in Viracept—a comprehensive human risk assessment based on threshold data for genotoxicity L Müller, E Gocke, T Lavé, T Pfister Toxicology Letters 190 (3), 317-329, 2009 | 99 | 2009 |
| Influence of isolation procedure, extracellular matrix and dexamethasone on the regulation of membrane transporters gene expression in rat hepatocytes O Luttringer, FP Theil, T Lavé, K Wernli-Kuratli, TW Guentert, A de Saizieu Biochemical pharmacology 64 (11), 1637-1650, 2002 | 98 | 2002 |
| Combining in vitro and in vivo pharmacokinetic data for prediction of hepatic drug clearance in humans by artificial neural networks and multivariate statistical techniques G Schneider, P Coassolo, T Lavé Journal of medicinal chemistry 42 (25), 5072-5076, 1999 | 98 | 1999 |
