| A "Silent" Polymorphism in the MDR1 Gene Changes Substrate Specificity C Kimchi-Sarfaty, JM Oh, IW Kim, ZE Sauna, AM Calcagno, SV Ambudkar, ... Science 315 (5811), 525-528, 2007 | 2940 | 2007 |
| P-glycoprotein: from genomics to mechanism SV Ambudkar, C Kimchi-Sarfaty, ZE Sauna, MM Gottesman Oncogene 22 (47), 7468-7485, 2003 | 1354 | 2003 |
| Understanding the contribution of synonymous mutations to human disease ZE Sauna, C Kimchi-Sarfaty Nature Reviews Genetics 12 (10), 683-691, 2011 | 1057 | 2011 |
| Recent advances in (therapeutic protein) drug development HAD Lagassé, A Alexaki, VL Simhadri, NH Katagiri, W Jankowski, ... F1000Research 6, 2017 | 483 | 2017 |
| Silent (synonymous) SNPs: should we care about them? R Hunt, ZE Sauna, SV Ambudkar, MM Gottesman, C Kimchi-Sarfaty Single nucleotide polymorphisms: Methods and protocols, 23-39, 2009 | 337 | 2009 |
| Exposing synonymous mutations RC Hunt, VL Simhadri, M Iandoli, ZE Sauna, C Kimchi-Sarfaty Trends in Genetics 30 (7), 308-321, 2014 | 332 | 2014 |
| Silent polymorphisms speak: how they affect pharmacogenomics and the treatment of cancer ZE Sauna, C Kimchi-Sarfaty, SV Ambudkar, MM Gottesman Cancer research 67 (20), 9609-9612, 2007 | 331 | 2007 |
| Evidence for a requirement for ATP hydrolysis at two distinct steps during a single turnover of the catalytic cycle of human P-glycoprotein ZE Sauna, SV Ambudkar Proceedings of the National Academy of Sciences 97 (6), 2515-2520, 2000 | 329 | 2000 |
| The power of the pump: mechanisms of action of P-glycoprotein (ABCB1) SV Ambudkar, IW Kim, ZE Sauna European Journal of Pharmaceutical Sciences 27 (5), 392-400, 2006 | 304 | 2006 |
| Synonymous mutations and ribosome stalling can lead to altered folding pathways and distinct minima CJ Tsai, ZE Sauna, C Kimchi-Sarfaty, SV Ambudkar, MM Gottesman, ... Journal of molecular biology 383 (2), 281-291, 2008 | 296 | 2008 |
| The mechanism of action of multidrug-resistance-linked P-glycoprotein ZE Sauna, MM Smith, M Müller, KM Kerr, SV Ambudkar Journal of bioenergetics and biomembranes 33, 481-491, 2001 | 261 | 2001 |
| Characterization of the catalytic cycle of ATP hydrolysis by human P-glycoprotein: the two ATP hydrolysis events in a single catalytic cycle are kinetically similar but affect … ZE Sauna, SV Ambudkar Journal of Biological Chemistry 276 (15), 11653-11661, 2001 | 248 | 2001 |
| Prevalence of pre-existing antibodies to CRISPR-associated nuclease Cas9 in the USA population VL Simhadri, J McGill, S McMahon, J Wang, H Jiang, ZE Sauna Molecular Therapy-Methods & Clinical Development 10, 105-112, 2018 | 228 | 2018 |
| Selective toxicity of NSC73306 in MDR1-positive cells as a new strategy to circumvent multidrug resistance in cancer JA Ludwig, G Szakács, SE Martin, BF Chu, C Cardarelli, ZE Sauna, ... Cancer research 66 (9), 4808-4815, 2006 | 225 | 2006 |
| The A-loop, a novel conserved aromatic acid subdomain upstream of the Walker A motif in ABC transporters, is critical for ATP binding SV Ambudkar, IW Kim, D Xia, ZE Sauna FEBS letters 580 (4), 1049-1055, 2006 | 225 | 2006 |
| About a switch: how P-glycoprotein (ABCB1) harnesses the energy of ATP binding and hydrolysis to do mechanical work ZE Sauna, SV Ambudkar Molecular cancer therapeutics 6 (1), 13-23, 2007 | 196 | 2007 |
| Fc fusion as a platform technology: potential for modulating immunogenicity D Levin, B Golding, SE Strome, ZE Sauna Trends in biotechnology 33 (1), 27-34, 2015 | 161 | 2015 |
| Correlation between steady-state ATP hydrolysis and vanadate-induced ADP trapping in human P-glycoprotein: evidence for ADP release as the rate-limiting step in the catalytic … KM Kerr, ZE Sauna, SV Ambudkar Journal of Biological Chemistry 276 (12), 8657-8664, 2001 | 133 | 2001 |
| Importance of the conserved Walker B glutamate residues, 556 and 1201, for the completion of the catalytic cycle of ATP hydrolysis by human P-glycoprotein (ABCB1) ZE Sauna, M Müller, XH Peng, SV Ambudkar Biochemistry 41 (47), 13989-14000, 2002 | 126 | 2002 |
| Disulfiram, an old drug with new potential therapeutic uses for human cancers and fungal infections ZE Sauna, S Shukla, SV Ambudkar Molecular BioSystems 1 (2), 127-134, 2005 | 125 | 2005 |
