Diamidines for human African trypanosomiasis WD Wilson, HP De Koningº, CA Olson, G Pohlig Current Opinion in Investigational Drugs 11 (8), 876-883, 2010 | 148 | 2010 |
Efficacy of the diamidine DB75 and its prodrug DB289, against murine models of human African trypanosomiasis JK Thuita, SM Karanja, T Wenzler, RE Mdachi, JM Ngotho, JM Kagira, ... Acta Tropica 108 (1), 6-10, 2008 | 106 | 2008 |
Trypanosoma brucei rhodesiense Transmitted by a Single Tsetse Fly Bite in Vervet Monkeys as a Model of Human African Trypanosomiasis JK Thuita, JM Kagira, D Mwangangi, E Matovu, CMR Turner, D Masiga PLoS neglected tropical diseases 2 (5), e238, 2008 | 73 | 2008 |
Hematological changes in vervet monkeys (Chlorocebus aethiops) during eight months' adaptation to captivity JM Kagira, M Ngotho, JK Thuita, NW Maina, J Hau American Journal of Primatology: Official Journal of the American Society of …, 2007 | 72* | 2007 |
Haematology of experimental Trypanosoma brucei rhodesiense infection in vervet monkeys JM Kagira, JK Thuita, M Ngotho, R Mdachi, DM Mwangangi, JM Ndung'u African Journal of Health Sciences 13 (3), 59-65, 2006 | 62 | 2006 |
Efficacy of the novel diamidine compound 2, 5-Bis (4-amidinophenyl)-furan-bis-O-Methlylamidoxime (Pafuramidine, DB289) against Trypanosoma brucei rhodesiense infection in … RE Mdachi, JK Thuita, JM Kagira, JM Ngotho, GA Murilla, JM Ndung'u, ... Antimicrobial agents and chemotherapy 53 (3), 953-957, 2009 | 53 | 2009 |
Pharmacology of DB844, an orally active aza analogue of pafuramidine, in a monkey model of second stage human African trypanosomiasis JK Thuita, MZ Wang, JM Kagira, CL Denton, MF Paine, RE Mdachi, ... PLoS neglected tropical diseases 6 (7), e1734, 2012 | 48 | 2012 |
Proinflammatory Cytokine Expression in the Early Phase of Trypanosoma brucei rhodesiense Infection in Vervet Monkeys (Cercopithecus aethiops) N Maina, JM Ngotho, T Were, JK Thuita, DM Mwangangi, JM Kagira, ... Infection and immunity 72 (5), 3063-3065, 2004 | 34 | 2004 |
Chemotherapy of second stage human African trypanosomiasis: comparison between the parenteral diamidine DB829 and its oral prodrug DB868 in vervet monkeys JK Thuita, KK Wolf, GA Murilla, AS Bridges, DW Boykin, JN Mutuku, Q Liu, ... PLoS neglected tropical diseases 9 (2), e0003409, 2015 | 30* | 2015 |
Influence of trypanocidal therapy on the haematology of vervet monkeys experimentally infected with Trypanosoma brucei rhodesiense M Ngotho, JM Kagira, C Kariuki, N Maina, JK Thuita, DM Mwangangi, ... Acta tropica 119 (1), 14-18, 2011 | 26 | 2011 |
Safety, pharmacokinetic, and efficacy studies of oral DB868 in a first stage vervet monkey model of human African trypanosomiasis JK Thuita, KK Wolf, GA Murilla, Q Liu, JN Mutuku, Y Chen, AS Bridges, ... PLoS neglected tropical diseases 7 (6), e2230, 2013 | 25 | 2013 |
Development of a rodent model for late stage rhodesian sleeping sickness JM Kagira, M Ngotho, J Thuita The journal of protozoology research 17 (2), 48-56, 2007 | 21 | 2007 |
Kenya Trypanosomiasis Research Institute cryobank for human and animal trypanosome isolates to support research: opportunities and challenges GA Murilla, K Ndung'u, JK Thuita, PK Gitonga, DT Kahiga, JE Auma, ... PLoS Neglected Tropical Diseases 8 (5), e2747, 2014 | 17 | 2014 |
Differential virulence and tsetse fly transmissibility of Trypanosoma congolense and Trypanosoma brucei strains PK Gitonga, GA Murilla, K Ndung’u, PC Thande, FN Wamwiri, JE Auma, ... Onderstepoort Journal of Veterinary Research 84 (1), 1-10, 2017 | 16 | 2017 |
Differential virulence of Trypanosoma brucei rhodesiense isolates does not influence the outcome of treatment with anti-trypanosomal drugs in the mouse model K Ndung’u, GA Murilla, JK Thuita, GN Ngae, JE Auma, PK Gitonga, ... PLoS One 15 (11), e0229060, 2020 | 15* | 2020 |
Route of inoculation influences Trypanosoma congolense and Trypanosoma brucei brucei virulence in Swiss white mice K Ndungu, D Thungu, F Wamwiri, P Mireji, G Ngae, P Gitonga, J Mulinge, ... PLoS One 14 (6), e0218441, 2019 | 13 | 2019 |
The prickly pear cactus (Opuntia fiscus-indica) cladode extracts modulate blood sugar in swiss white albino mice PM Mokua, O Mayunzu, M Obonyo, J Thuita, J Mutuku, J Rutto, G Murilla International Journal of Diabetes Research, 2016 | 11 | 2016 |
Coenzyme Q10 and endogenous antioxidants neuro-protect mice brain against deleterious effects of melarsoprol and Trypanasoma brucei rhodesiense JN Nyariki, JK Thuita, AM Wambugu, NO Nyamweya, K Rashid, ... J. Nat. Sci. Res 8 (4), 61-73, 2018 | 10 | 2018 |
Influence of cyclophosphamide on the haematological profile of laboratory bred African soft-furred rats (Mastomys natalensis) JM Kagira, N Maina, JK Thuita, M Ngotho, J Hau | 10 | 2005 |
Comparative pathogenicity of Trypanosoma brucei rhodesiense strains in Swiss white mice and Mastomys natalensis rats MW Muchiri, K Ndung’u, JK Kibugu, JK Thuita, PK Gitonga, GN Ngae, ... Acta tropica 150, 23-28, 2015 | 9 | 2015 |