Denis M Grant
Denis M Grant
Professor of Pharmacology & Toxicology, University of Toronto
Verified email at utoronto.ca
Title
Cited by
Cited by
Year
Human Arylamine N-Acetyltransferase Genes: Isolation, Chromosomal Localization, and Functional Expression
M Blum, DM Grant, W McBride, M Heim, UA Meyer
DNA and cell biology 9 (3), 193-203, 1990
5441990
Nomenclature for N-acetyltransferases
KP Vatsis, WW Weber, DA Bell, JM Dupret, DAP Evans, DM Grant, ...
Pharmacogenetics and Genomics 5 (1), 1-17, 1995
4711995
Molecular mechanism of slow acetylation of drugs and carcinogens in humans.
M Blum, A Demierre, DM Grant, M Heim, UA Meyer
Proceedings of the National Academy of Sciences 88 (12), 5237-5241, 1991
4561991
Differences in metabolism of sulfonamides predisposing to idiosyncratic toxicity
NH SHEAR, SP SPIELBERG, DM GRANT, BK TANG, W KALOW
Annals of Internal Medicine 105 (2), 179-184, 1986
4271986
Metabolic activation and deactivation of arylamine carcinogens by recombinant human NAT1 and polymorphic NAT2 acetyltransferases
DW Hein, MA Doll, TD Rustan, K Gray, Y Feng, RJ Ferguson, DM Grant
Carcinogenesis 14 (8), 1633-1638, 1993
3841993
Variability in caffeine metabolism
DM Grant, BK Tang, W Kalow
Clinical Pharmacology & Therapeutics 33 (5), 591-602, 1983
3381983
Monomorphic and polymorphic human arylamine N-acetyltransferases: a comparison of liver isozymes and expressed products of two cloned genes.
DM Grant, M Blum, M Beer, UA Meyer
Molecular pharmacology 39 (2), 184-191, 1991
3091991
Human acetyltransferase polymorphisms
DM Grant, NC Hughes, SA Janezic, GH Goodfellow, HJ Chen, A Gaedigk, ...
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 376 (1 …, 1997
3031997
Biotransformation of caffeine, paraxanthine, theophylline, and theobromine by polycyclic aromatic hydrocarbon-inducible cytochrome (s) P-450 in human liver microsomes.
ME Campbell, DM Grant, T Inaba, W Kalow
Drug Metabolism and Disposition 15 (2), 237-249, 1987
2601987
A simple test for acetylator phenotype using caffeine.
DM Grant, BK Tang, W Kalow
British journal of clinical pharmacology 17 (4), 459-464, 1984
2351984
Principles of medical pharmacology
AJ Atkinson
1812006
Acetylation pharmacogenetics. The slow acetylator phenotype is caused by decreased or absent arylamine N-acetyltransferase in human liver.
DM Grant, K Mörike, M Eichelbaum, UA Meyer
The Journal of clinical investigation 85 (3), 968-972, 1990
1611990
Characterization of the microsomal epoxide hydrolase gene in patients with anticonvulsant adverse drug reactions.
A Gaedigk, SP Spielberg, DM Grant
Pharmacogenetics 4 (3), 142-153, 1994
1571994
Localization of N-Acetyltransferases NAT1 and NAT2 in Human Tissues
KF Windmill, A Gaedigk, P de la M. Hall, H Samaratunga, DM Grant, ...
Toxicological Sciences 54 (1), 19-29, 2000
1562000
Molecular genetics of the N-acetyltransferases
DM Grant
Pharmacogenetics and Genomics 3 (1), 45-50, 1993
1511993
The role of xenobiotic metabolizing enzymes in arylamine toxicity and carcinogenesis: functional and localization studies
KF Windmill, RA McKinnon, X Zhu, A Gaedigk, DM Grant, ME McManus
Mutation Research/Fundamental and Molecular Mechanisms of Mutagenesis 376 (1 …, 1997
1471997
Genetic polymorphisms of drug metabolism
UA Meyer
Fundamental & clinical pharmacology 4 (6), 595-615, 1990
1471990
Identification and characterization of variant alleles of human acetyltransferase NAT1 with defective function using p-aminosalicylate as an in-vivo and in-vitro probe.
NC Hughes, SA Janezic, KL McQueen, MA Jewett, T Castranio, DA Bell, ...
Pharmacogenetics 8 (1), 55-66, 1998
1461998
Site-directed mutagenesis of recombinant human arylamine N-acetyltransferase expressed in Escherichia coli. Evidence for direct involvement of Cys68 in the catalytic mechanism …
JM Dupret, DM Grant
Journal of Biological Chemistry 267 (11), 7381-7385, 1992
1431992
Update on consensus arylamine N-acetyltransferase gene nomenclature
DW Hein, DM Grant, E Sim
Pharmacogenetics and Genomics 10 (4), 291-292, 2000
1362000
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