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Leo J. Lee
Leo J. Lee
Senior Research Scientist, University of Toronto
Verified email at psi.toronto.edu - Homepage
Title
Cited by
Cited by
Year
Deep surveying of alternative splicing complexity in the human transcriptome by high-throughput sequencing
Q Pan, O Shai, LJ Lee, BJ Frey, BJ Blencowe
Nature genetics 40 (12), 1413-1415, 2008
38052008
The human splicing code reveals new insights into the genetic determinants of disease
HY Xiong, B Alipanahi, LJ Lee, H Bretschneider, D Merico, RKC Yuen, ...
Science 347 (6218), 1254806, 2015
11512015
The evolutionary landscape of alternative splicing in vertebrate species
NL Barbosa-Morais, M Irimia, Q Pan, HY Xiong, S Gueroussov, LJ Lee, ...
Science 338 (6114), 1587-1593, 2012
9572012
Deep learning of the tissue-regulated splicing code
MKK Leung, HY Xiong, LJ Lee, BJ Frey
Bioinformatics 30 (12), i121-i129, 2014
5042014
The EWS gene, involved in Ewing family of tumors, malignant melanoma of soft parts and desmoplastic small round cell tumors, codes for an RNA binding protein with novel …
T Ohno, M Ouchida, L Lee, Z Gatalica, VN Rao, ES Reddy
Oncogene 9 (10), 3087-3097, 1994
2341994
Current-generation high-throughput sequencing: deepening insights into mammalian transcriptomes
BJ Blencowe, S Ahmad, LJ Lee
Genes & development 23 (12), 1379-1386, 2009
2072009
TLS/FUS fusion domain of TLS/FUS-erg chimeric protein resulting from the t (16; 21) chromosomal translocation in human myeloid leukemia functions as a transcriptional …
DD Prasad, M Ouchida, L Lee, VN Rao, ES Reddy
Oncogene 9 (12), 3717-3729, 1994
1941994
Genome-wide analysis of alternative splicing in Caenorhabditis elegans
AK Ramani, JA Calarco, Q Pan, S Mavandadi, Y Wang, AC Nelson, ...
Genome research 21 (2), 342-348, 2011
1702011
Key parameters of tumor epitope immunogenicity revealed through a consortium approach improve neoantigen prediction
DK Wells, MM van Buuren, KK Dang, VM Hubbard-Lucey, KCF Sheehan, ...
Cell 183 (3), 818-834. e13, 2020
1532020
The EWS-ATF-1 gene involved in malignant melanoma of soft parts with t (12; 22) chromosome translocation, encodes a constitutive transcriptional activator.
Y Fujimura, T Ohno, H Siddique, L Lee, VN Rao, ES Reddy
Oncogene 12 (1), 159-167, 1996
1441996
Functional coordination of alternative splicing in the mammalian central nervous system
M Fagnani, Y Barash, JY Ip, C Misquitta, Q Pan, AL Saltzman, O Shai, ...
Genome biology 8 (6), 1-17, 2007
1222007
Generating and designing DNA with deep generative models
N Killoran, LJ Lee, A Delong, D Duvenaud, BJ Frey
arXiv preprint arXiv:1712.06148, 2017
1102017
Mutations in STAMBP, encoding a deubiquitinating enzyme, cause microcephaly–capillary malformation syndrome
LM McDonell, GM Mirzaa, D Alcantara, J Schwartzentruber, MT Carter, ...
Nature genetics 45 (5), 556-562, 2013
962013
Physicians' guideline adherence is associated with long‐term heart failure mortality in outpatients with heart failure with reduced ejection fraction: the QUALIFY international …
M Komajda, J Schöpe, S Wagenpfeil, L Tavazzi, M Böhm, P Ponikowski, ...
European Journal of Heart Failure 21 (7), 921-929, 2019
832019
Characterization of the DNA binding and transcriptional activation domains of the erg protein.
HR Siddique, VN Rao, L Lee, ES Reddy
Oncogene 8 (7), 1751-1755, 1993
751993
Immunity through swarms: Agent-based simulations of the human immune system
C Jacob, J Litorco, L Lee
International Conference on Artificial Immune Systems, 400-412, 2004
722004
Adaptive Kalman filtering and smoothing for tracking vocal tract resonances using a continuous-valued hidden dynamic model
L Deng, LJ Lee, H Attias, A Acero
IEEE transactions on audio, speech, and language processing 15 (1), 13-23, 2006
642006
BET inhibition blocks inflammation-induced cardiac dysfunction and SARS-CoV-2 infection
RJ Mills, SJ Humphrey, PRJ Fortuna, M Lor, SR Foster, GA Quaife-Ryan, ...
Cell 184 (8), 2167-2182. e22, 2021
612021
EWS-ATF-1 chimeric protein in soft tissue clear cell sarcoma associates with CREB-binding protein and interferes with p53-mediated trans-activation function
Y Fujimura, H Siddique, L Lee, VN Rao, ESP Reddy
Oncogene 20 (46), 6653-6659, 2001
592001
Systems and methods for classifying, prioritizing and interpreting genetic variants and therapies using a deep neural network
B Frey, MKK Leung, AT Delong, HY Xiong, B Alipanahi, LJ Lee, ...
US Patent 10,185,803, 2019
542019
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