Gain of toxicity from ALS/FTD-linked repeat expansions in C9ORF72 is alleviated by antisense oligonucleotides targeting GGGGCC-containing RNAs J Jiang, Q Zhu, TF Gendron, S Saberi, M McAlonis-Downes, A Seelman, ... Neuron 90 (3), 535-550, 2016 | 560 | 2016 |
Progranulin is neurotrophic in vivo and protects against a mutant TDP-43 induced axonopathy AS Laird, A Van Hoecke, L De Muynck, M Timmers, L Van Den Bosch, ... PloS one 5 (10), e13368, 2010 | 187 | 2010 |
Progranulin functions as a cathepsin D chaperone to stimulate axonal outgrowth in vivo S Beel, M Moisse, M Damme, L De Muynck, W Robberecht, ... Human molecular genetics 26 (15), 2850-2863, 2017 | 125 | 2017 |
Cellular effects of progranulin in health and disease L De Muynck, P Van Damme Journal of Molecular Neuroscience 45, 549-560, 2011 | 122 | 2011 |
The neurotrophic properties of progranulin depend on the granulin E domain but do not require sortilin binding L De Muynck, S Herdewyn, S Beel, W Scheveneels, L Van Den Bosch, ... Neurobiology of aging 34 (11), 2541-2547, 2013 | 92 | 2013 |
Microglial upregulation of progranulin as a marker of motor neuron degeneration T Philips, L De Muynck, H Nguyen Thi Thu, B Weynants, P Vanacker, ... Journal of Neuropathology & Experimental Neurology 69 (12), 1191-1200, 2010 | 86 | 2010 |
Restoration of progranulin expression rescues cortical neuron generation in an induced pluripotent stem cell model of frontotemporal dementia S Raitano, L Ordovàs, L De Muynck, W Guo, I Espuny-Camacho, ... Stem cell reports 4 (1), 16-24, 2015 | 79 | 2015 |
RNA sequencing analysis of intracranial aneurysm walls reveals involvement of lysosomes and immunoglobulins in rupture R Kleinloog, BH Verweij, P Van Der Vlies, P Deelen, MA Swertz, ... Stroke 47 (5), 1286-1293, 2016 | 67 | 2016 |
Genetically engineered iPSC-derived FTDP-17 MAPT neurons display mutation-specific neurodegenerative and neurodevelopmental phenotypes A Verheyen, A Diels, J Reumers, K Van Hoorde, I Van den Wyngaert, ... Stem cell reports 11 (2), 363-379, 2018 | 56 | 2018 |
Immunologic profiles of multiple sclerosis treatments reveal shared early B cell alterations J Dooley, I Pauwels, D Franckaert, I Smets, JE Garcia-Perez, K Hilven, ... Neuroimmunology & Neuroinflammation 3 (4), e240, 2016 | 52 | 2016 |
Differentially expressed genes in Alzheimer’s disease highlighting the roles of microglia genes including OLR1 and astrocyte gene CDK2AP1 QS Li, L De Muynck Brain, Behavior, & Immunity-Health 13, 100227, 2021 | 32 | 2021 |
RNA-sequencing highlights inflammation and impaired integrity of the vascular wall in brain arteriovenous malformations AJ Hauer, R Kleinloog, F Giuliani, GJE Rinkel, GA de Kort, ... Stroke 51 (1), 268-274, 2020 | 26 | 2020 |
PIKfyve activity is required for lysosomal trafficking of tau aggregates and tau seeding AC Soares, A Ferreira, J Mariën, C Delay, E Lee, JQ Trojanowski, ... Journal of Biological Chemistry 296, 2021 | 21 | 2021 |
Progranulin does not affect motor neuron degeneration in mutant SOD1 mice and rats S Herdewyn, L De Muynck, L Van Den Bosch, W Robberecht, ... Neurobiology of aging 34 (10), 2302-2303, 2013 | 11 | 2013 |
Absence of uptake and prion-like spreading of alpha-synuclein and tau after intravitreal injection of preformed fibrils L Veys, J Van Houcke, J Aerts, S Van Pottelberge, M Mahieu, A Coens, ... Frontiers in Aging Neuroscience 12, 614587, 2021 | 8 | 2021 |
The 3-O sulfation of heparan sulfate proteoglycans contributes to the cellular internalization of tau aggregates A Ferreira, I Royaux, J Liu, Z Wang, G Su, D Moechars, N Callewaert, ... BMC Molecular and Cell Biology 23 (1), 61, 2022 | 5 | 2022 |
Protein interactors of 3-O sulfated heparan sulfates in human MCI and age-matched control cerebrospinal fluid A Ferreira, E Timmerman, A Staes, M Vuylsteke, L De Muynck, K Gevaert Scientific Data 10 (1), 121, 2023 | 3 | 2023 |
Characterization of APOE Christchurch carriers in 455,306 UK Biobank participants KY He, EA Khramtsova, A Cabrera-Socorro, Y Zhang, S Li, BAJ Sarver, ... Molecular Neurodegeneration 18 (1), 92, 2023 | 1 | 2023 |
The development of drug therapies for frontotemporal dementia caused by progranulin mutations L De Muynck, P Van Damme Atta-ur-Rahman, editor. Frontiers in clinical drug research-Alzheimer …, 2015 | 1 | 2015 |
Peripheral progranulin levels do not reflect brain progranulin levels LD Muynck, PV Damme Future Neurology 9 (5), 521-524, 2014 | 1 | 2014 |