Masayuki Yamamoto
Masayuki Yamamoto
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An Nrf2/small Maf heterodimer mediates the induction of phase II detoxifying enzyme genes through antioxidant response elements
K Itoh, T Chiba, S Takahashi, T Ishii, K Igarashi, Y Katoh, T Oyake, ...
Biochemical and biophysical research communications 236 (2), 313-322, 1997
Keap1 represses nuclear activation of antioxidant responsive elements by Nrf2 through binding to the amino-terminal Neh2 domain
K Itoh, N Wakabayashi, Y Katoh, T Ishii, K Igarashi, JD Engel, ...
Genes & development 13 (1), 76-86, 1999
Oxidative stress sensor Keap1 functions as an adaptor for Cul3-based E3 ligase to regulate proteasomal degradation of Nrf2
A Kobayashi, MI Kang, H Okawa, M Ohtsuji, Y Zenke, T Chiba, K Igarashi, ...
Molecular and cellular biology 24 (16), 7130-7139, 2004
Homeostatic levels of p62 control cytoplasmic inclusion body formation in autophagy-deficient mice
M Komatsu, S Waguri, M Koike, Y Sou, T Ueno, T Hara, N Mizushima, ...
Cell 131 (6), 1149-1163, 2007
The selective autophagy substrate p62 activates the stress responsive transcription factor Nrf2 through inactivation of Keap1
M Komatsu, H Kurokawa, S Waguri, K Taguchi, A Kobayashi, Y Ichimura, ...
Nature cell biology 12 (3), 213-223, 2010
Direct evidence that sulfhydryl groups of Keap1 are the sensors regulating induction of phase 2 enzymes that protect against carcinogens and oxidants
AT Dinkova-Kostova, WD Holtzclaw, RN Cole, K Itoh, N Wakabayashi, ...
Proceedings of the National Academy of Sciences 99 (18), 11908-11913, 2002
Nrf2–Keap1 defines a physiologically important stress response mechanism
H Motohashi, M Yamamoto
Trends in molecular medicine 10 (11), 549-557, 2004
Transcription factor Nrf2 coordinately regulates a group of oxidative stress-inducible genes in macrophages
T Ishii, K Itoh, S Takahashi, H Sato, T Yanagawa, Y Katoh, S Bannai, ...
Journal of Biological Chemistry 275 (21), 16023-16029, 2000
Molecular mechanisms of the Keap1–Nrf2 pathway in stress response and cancer evolution
K Taguchi, H Motohashi, M Yamamoto
Genes to cells 16 (2), 123-140, 2011
Identification of Nrf2-regulated genes induced by the chemopreventive agent sulforaphane by oligonucleotide microarray
RK Thimmulappa, KH Mai, S Srisuma, TW Kensler, M Yamamoto, ...
Cancer research 62 (18), 5196-5203, 2002
Nrf2 suppresses macrophage inflammatory response by blocking proinflammatory cytokine transcription
EH Kobayashi, T Suzuki, R Funayama, T Nagashima, M Hayashi, ...
Nature communications 7 (1), 11624, 2016
Sensitivity to carcinogenesis is increased and chemoprotective efficacy of enzyme inducers is lost in nrf2 transcription factor-deficient mice
M Ramos-Gomez, MK Kwak, PM Dolan, K Itoh, M Yamamoto, P Talalay, ...
Proceedings of the National Academy of Sciences 98 (6), 3410-3415, 2001
Nrf2 redirects glucose and glutamine into anabolic pathways in metabolic reprogramming
Y Mitsuishi, K Taguchi, Y Kawatani, T Shibata, T Nukiwa, H Aburatani, ...
Cancer cell 22 (1), 66-79, 2012
Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression
M McMahon, K Itoh, M Yamamoto, JD Hayes
Journal of Biological Chemistry 278 (24), 21592-21600, 2003
Molecular mechanisms activating the Nrf2-Keap1 pathway of antioxidant gene regulation
M Kobayashi, M Yamamoto
Antioxidants & redox signaling 7 (3-4), 385-394, 2005
The KEAP1-NRF2 system: a thiol-based sensor-effector apparatus for maintaining redox homeostasis
M Yamamoto, TW Kensler, H Motohashi
Physiological reviews 98 (3), 1169-1203, 2018
Genetic ablation of Nrf2 enhances susceptibility to cigarette smoke–induced emphysema in mice
T Rangasamy, CY Cho, RK Thimmulappa, L Zhen, SS Srisuma, ...
The Journal of clinical investigation 114 (9), 1248-1259, 2004
Protection against electrophile and oxidant stress by induction of the phase 2 response: fate of cysteines of the Keap1 sensor modified by inducers
N Wakabayashi, AT Dinkova-Kostova, WD Holtzclaw, MI Kang, ...
Proceedings of the National Academy of Sciences 101 (7), 2040-2045, 2004
Nrf2 is a critical regulator of the innate immune response and survival during experimental sepsis
RK Thimmulappa, H Lee, T Rangasamy, SP Reddy, M Yamamoto, ...
The Journal of clinical investigation 116 (4), 984-995, 2016
Phosphorylation of p62 activates the Keap1-Nrf2 pathway during selective autophagy
Y Ichimura, S Waguri, Y Sou, S Kageyama, J Hasegawa, R Ishimura, ...
Molecular cell 51 (5), 618-631, 2013
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