Ulrich Lächelt
Ulrich Lächelt
Ass.Prof. for Preclinical Medicines Development, University of Vienna
Verified email at - Homepage
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Nucleic acid therapeutics using polyplexes: a journey of 50 years (and beyond)
U Lächelt, E Wagner
Chemical reviews 115 (19), 11043-11078, 2015
Imparting functionality to MOF nanoparticles by external surface selective covalent attachment of polymers
A Zimpel, T Preiß, R Röder, H Engelke, M Ingrisch, M Peller, JO Rädler, ...
Chemistry of Materials 28 (10), 3318-3326, 2016
Multifunctional efficiency: extending the concept of atom economy to functional nanomaterials
R Freund, U Lächelt, T Gruber, B Rühle, S Wuttke
ACS nano 12 (3), 2094-2105, 2018
Nanosized multifunctional polyplexes for receptor-mediated siRNA delivery
C Dohmen, D Edinger, T Fröhlich, L Schreiner, U Lächelt, C Troiber, ...
ACS nano 6 (6), 5198-5208, 2012
Multifunctional nanoparticles by coordinative self-assembly of His-tagged units with metal–organic frameworks
R Röder, T Preiß, P Hirschle, B Steinborn, A Zimpel, M Höhn, ...
Journal of the American Chemical Society 139 (6), 2359-2368, 2017
Defined folate-PEG-siRNA conjugates for receptor-specific gene silencing
C Dohmen, T Fröhlich, U Lächelt, I Röhl, HP Vornlocher, P Hadwiger, ...
Molecular Therapy-Nucleic Acids 1, e7, 2012
Fine-tuning of proton sponges by precise diaminoethanes and histidines in pDNA polyplexes
U Lächelt, P Kos, FM Mickler, A Herrmann, EE Salcher, W Rödl, ...
Nanomedicine: Nanotechnology, Biology and Medicine 10 (1), 35-44, 2014
Polyplex evolution: understanding biology, optimizing performance
A Hall, U Lächelt, J Bartek, E Wagner, SM Moghimi
Molecular Therapy 25 (7), 1476-1490, 2017
The chemistry of reticular framework nanoparticles: MOF, ZIF, and COF materials
E Ploetz, H Engelke, U Lächelt, S Wuttke
Advanced Functional Materials 30 (41), 1909062, 2020
Solid-phase-assisted synthesis of targeting peptide–PEG–oligo (ethane amino) amides for receptor-mediated gene delivery
I Martin, C Dohmen, C Mas-Moruno, C Troiber, P Kos, D Schaffert, ...
Organic & biomolecular chemistry 10 (16), 3258-3268, 2012
Histidine-rich stabilized polyplexes for cMet-directed tumor-targeted gene transfer
P Kos, U Lächelt, A Herrmann, FM Mickler, M Döblinger, D He, ...
Nanoscale 7 (12), 5350-5362, 2015
Dual antitumoral potency of EG5 siRNA nanoplexes armed with cytotoxic bifunctional glutamyl-methotrexate targeting ligand
DJ Lee, E Kessel, D Edinger, D He, PM Klein, LV von Voithenberg, ...
Biomaterials 77, 98-110, 2016
The current status of MOF and COF applications
R Freund, O Zaremba, G Arnauts, R Ameloot, G Skorupskii, M Dincă, ...
Angewandte Chemie International Edition 60 (45), 23975-24001, 2021
Combinatorial optimization of sequence-defined oligo (ethanamino) amides for folate receptor-targeted pDNA and siRNA delivery
D He, K Müller, A Krhac Levacic, P Kos, U Lächelt, E Wagner
Bioconjugate chemistry 27 (3), 647-659, 2016
Tumoral gene silencing by receptor-targeted combinatorial siRNA polyplexes
DJ Lee, D He, E Kessel, K Padari, S Kempter, U Lächelt, JO Rädler, ...
Journal of controlled release 244, 280-291, 2016
Coordinative binding of polymers to metal–organic framework nanoparticles for control of interactions at the biointerface
A Zimpel, N Al Danaf, B Steinborn, J Kuhn, M Höhn, T Bauer, P Hirschle, ...
ACS nano 13 (4), 3884-3895, 2019
Augmented glioma-targeted theranostics using multifunctional polymer-coated carbon nanodots
S Wang, C Li, M Qian, H Jiang, W Shi, J Chen, U Lächelt, E Wagner, W Lu, ...
Biomaterials 141, 29-39, 2017
pH-reversible cationic RNase A conjugates for enhanced cellular delivery and tumor cell killing
X Liu, P Zhang, D He, W Rödl, T Preiß, JO Rädler, E Wagner, ...
Biomacromolecules 17 (1), 173-182, 2016
Dual-targeted polyplexes based on sequence-defined peptide-PEG-oligoamino amides
P Kos, U Lächelt, D He, Y Nie, Z Gu, E Wagner
Journal of pharmaceutical sciences 104 (2), 464-475, 2015
Synthetic polyglutamylation of dual-functional MTX ligands for enhanced combined cytotoxicity of poly (I: C) nanoplexes
U Lächelt, V Wittmann, K Müller, D Edinger, P Kos, M Höhn, ...
Molecular pharmaceutics 11 (8), 2631-2639, 2014
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