| Insulin resistance or insulin deficiency: which is the primary cause of NIDDM? SI Taylor, D Accili, Y Imai Diabetes 43 (6), 735-741, 1994 | 479 | 1994 |
| Evidence that IRS-2 phosphorylation is required for insulin action in hepatocytes KI Rother, Y Imai, M Caruso, F Beguinot, P Formisano, D Accili Journal of Biological Chemistry 273 (28), 17491-17497, 1998 | 206 | 1998 |
| Reduction of hepatosteatosis and lipid levels by an adipose differentiation-related protein antisense oligonucleotide Y Imai, GM Varela, MB Jackson, MJ Graham, RM Crooke, RS Ahima Gastroenterology 132 (5), 1947-1954, 2007 | 204 | 2007 |
| Association of proinflammatory cytokines and islet resident leucocytes with islet dysfunction in type 2 diabetes MJ Butcher, D Hallinger, E Garcia, Y Machida, S Chakrabarti, J Nadler, ... Diabetologia 57, 491-501, 2014 | 178 | 2014 |
| Substitutions for hydrophobic amino acids in the N-terminal domains of IGFBP-3 and-5 markedly reduce IGF-I binding and alter their biologic actions Y Imai, A Moralez, U Andag, JB Clarke, WH Busby, DR Clemmons Journal of Biological Chemistry 275 (24), 18188-18194, 2000 | 158 | 2000 |
| Roles of phosphatidylinositol 3-kinase and mitogen-activated protein kinase pathways in stimulation of vascular smooth muscle cell migration and deoxyriboncleic acid synthesis … Y Imai, DR Clemmons Endocrinology 140 (9), 4228-4235, 1999 | 151 | 1999 |
| Integration of pro-inflammatory cytokines, 12-lipoxygenase and NOX-1 in pancreatic islet beta cell dysfunction JR Weaver, TR Holman, Y Imai, A Jadhav, V Kenyon, DJ Maloney, ... Molecular and cellular endocrinology 358 (1), 88-95, 2012 | 137 | 2012 |
| Variant sequences of insulin receptor substrate-1 in patients with noninsulin-dependent diabetes mellitus Y Imai, A Fusco, Y Suzuki, MA Lesniak, R D'Alfonso, G Sesti, A Bertoli, ... The Journal of Clinical Endocrinology & Metabolism 79 (6), 1655-1658, 1994 | 137 | 1994 |
| Activation of transmembrane bile acid receptor TGR5 modulates pancreatic islet α cells to promote glucose homeostasis DP Kumar, A Asgharpour, F Mirshahi, SH Park, S Liu, Y Imai, JL Nadler, ... Journal of Biological Chemistry 291 (13), 6626-6640, 2016 | 132 | 2016 |
| Islet inflammation: a unifying target for diabetes treatment? Y Imai, AD Dobrian, MA Morris, JL Nadler Trends in endocrinology & metabolism 24 (7), 351-360, 2013 | 123 | 2013 |
| Protease-resistant form of insulin-like growth factor-binding protein 5 is an inhibitor of insulin-like growth factor-I actions on porcine smooth muscle cells in culture. Y Imai, WH Busby, CE Smith, JB Clarke, AJ Garmong, GD Horwitz, ... The Journal of clinical investigation 100 (10), 2596-2605, 1997 | 113 | 1997 |
| Neuropeptide Y deficiency attenuates responses to fasting and high-fat diet in obesity-prone mice HR Patel, Y Qi, EJ Hawkins, SM Hileman, JK Elmquist, Y Imai, RS Ahima Diabetes 55 (11), 3091-3098, 2006 | 100 | 2006 |
| Interaction between cytokines and inflammatory cells in islet dysfunction, insulin resistance and vascular disease Y Imai, AD Dobrian, JR Weaver, MJ Butcher, BK Cole, EV Galkina, ... Diabetes, Obesity and Metabolism 15 (s3), 117-129, 2013 | 89 | 2013 |
| Insulin secretion is increased in pancreatic islets of neuropeptide Y-deficient mice Y Imai, HR Patel, EJ Hawkins, NM Doliba, FM Matschinsky, RS Ahima Endocrinology 148 (12), 5716-5723, 2007 | 84 | 2007 |
| Effects of perilipin 2 antisense oligonucleotide treatment on hepatic lipid metabolism and gene expression Y Imai, S Boyle, GM Varela, E Caron, X Yin, R Dhir, R Dhir, MJ Graham, ... Physiological genomics 44 (22), 1125-1131, 2012 | 73 | 2012 |
| Alterations of pancreatic islet structure, metabolism and gene expression in diet-induced obese C57BL/6J mice R Roat, V Rao, NM Doliba, FM Matschinsky, JW Tobias, E Garcia, ... PloS one 9 (2), e86815, 2014 | 71 | 2014 |
| Connecting pancreatic islet lipid metabolism with insulin secretion and the development of type 2 diabetes Y Imai, RS Cousins, S Liu, BM Phelps, JA Promes Annals of the New York Academy of Sciences 1461 (1), 53-72, 2020 | 69 | 2020 |
| Effect of growth factors on hyaluronan and proteoglycan synthesis by retroocular tissue fibroblasts of Graves' ophthalmopathy in culture Y Imai, R Odajima, Y Inoue, Y Shishiba European journal of endocrinology 126 (6), 541-552, 1992 | 66 | 1992 |
| Expression of variant forms of insulin receptor substrate-1 identified in patients with noninsulin-dependent diabetes mellitus Y Imai, N Philippe, G Sesti, D Accili, SI Taylor The Journal of Clinical Endocrinology & Metabolism 82 (12), 4201-4207, 1997 | 65 | 1997 |
| Insulin-like growth factor I increases αvβ3 affinity by increasing the amount of integrin-associated protein that is associated with non-raft domains of the cellular membrane LA Maile, Y Imai, JB Clarke, DR Clemmons Journal of Biological Chemistry 277 (3), 1800-1805, 2002 | 63 | 2002 |
Rexford AhimaBloomberg Distinguished Professor, Johns Hopkins UniversityVerified email at jhmi.edu
