James Mitchell
James Mitchell
Associate Professor of Genetics and Complex Diseases, Harvard T. H. Chan School of Public Health
Verified email at - Homepage
Cited by
Cited by
An essential role for senescent cells in optimal wound healing through secretion of PDGF-AA
M Demaria, N Ohtani, SA Youssef, F Rodier, W Toussaint, JR Mitchell, ...
Developmental cell 31 (6), 722-733, 2014
A telomerase component is defective in the human disease dyskeratosis congenita
JR Mitchell, E Wood, K Collins
Nature 402 (6761), 551-555, 1999
Genomic relationships, novel loci, and pleiotropic mechanisms across eight psychiatric disorders
PH Lee, V Anttila, H Won, YCA Feng, J Rosenthal, Z Zhu, EM Tucker-Drob, ...
Cell 179 (7), 1469-1482. e11, 2019
Telomerase in the human organism
K Collins, JR Mitchell
Oncogene 21 (4), 564-579, 2002
A box H/ACA small nucleolar RNA-like domain at the human telomerase RNA 3′ end
JR Mitchell, J Cheng, K Collins
Molecular and cellular biology 19 (1), 567-576, 1999
Defective mitophagy in XPA via PARP-1 hyperactivation and NAD+/SIRT1 reduction
EF Fang, M Scheibye-Knudsen, LE Brace, H Kassahun, T SenGupta, ...
Cell 157 (4), 882-896, 2014
Interventions to slow aging in humans: are we ready?
VD Longo, A Antebi, A Bartke, N Barzilai, HM Brown‐Borg, C Caruso, ...
Aging cell 14 (4), 497-510, 2015
Endogenous hydrogen sulfide production is essential for dietary restriction benefits
C Hine, E Harputlugil, Y Zhang, C Ruckenstuhl, BC Lee, L Brace, ...
Cell 160 (1), 132-144, 2015
Effects of sex, strain, and energy intake on hallmarks of aging in mice
SJ Mitchell, J Madrigal-Matute, M Scheibye-Knudsen, E Fang, M Aon, ...
Cell metabolism 23 (6), 1093-1112, 2016
Impairment of an endothelial NAD+-H2S signaling network is a reversible cause of vascular aging
A Das, GX Huang, MS Bonkowski, A Longchamp, C Li, MB Schultz, ...
Cell 173 (1), 74-89. e20, 2018
Human telomerase activation requires two independent interactions between telomerase RNA and telomerase reverse transcriptase
JR Mitchell, K Collins
Molecular cell 6 (2), 361-371, 2000
The multidomain structure of Orc1 p reveals similarity to regulators of DNA replication and transcriptional silencing
SP Bell, J Mitchell, J Leber, R Kobayashi, B Stillman
Cell 83 (4), 563-568, 1995
Short‐term dietary restriction and fasting precondition against ischemia reperfusion injury in mice
JR Mitchell, M Verweij, K Brand, M Van De Ven, N Goemaere, ...
Aging cell 9 (1), 40-53, 2010
Amino acid restriction triggers angiogenesis via GCN2/ATF4 regulation of VEGF and H2S production
A Longchamp, T Mirabella, A Arduini, MR MacArthur, A Das, ...
Cell 173 (1), 117-129. e14, 2018
Impaired genome maintenance suppresses the growth hormone–insulin-like growth factor 1 axis in mice with Cockayne syndrome
I Van Der Pluijm, GA Garinis, RMC Brandt, TGMF Gorgels, SW Wijnhoven, ...
PLoS biology 5 (1), e2, 2007
Selective persulfide detection reveals evolutionarily conserved antiaging effects of S-sulfhydration
J Zivanovic, E Kouroussis, JB Kohl, B Adhikari, B Bursac, S Schott-Roux, ...
Cell metabolism 30 (6), 1152-1170. e13, 2019
Amino acid sensing in dietary-restriction-mediated longevity: roles of signal-transducing kinases GCN2 and TOR
J Gallinetti, E Harputlugil, JR Mitchell
Biochemical Journal 449 (1), 1-10, 2013
RNA binding domain of telomerase reverse transcriptase
CK Lai, JR Mitchell, K Collins
Molecular and cellular biology, 2001
CDC45, a novel yeast gene that functions with the origin recognition complex and Mcm proteins in initiation of DNA replication
L Zou, J Mitchell, B Stillman
Molecular and cellular biology, 1997
Divide and conquer: nucleotide excision repair battles cancer and ageing
JR Mitchell, JHJ Hoeijmakers, LJ Niedernhofer
Current opinion in cell biology 15 (2), 232-240, 2003
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