Giles Hardingham
Giles Hardingham
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Extrasynaptic NMDARs oppose synaptic NMDARs by triggering CREB shut-off and cell death pathways
GE Hardingham, Y Fukunaga, H Bading
Nature neuroscience 5 (5), 405-414, 2002
Synaptic versus extrasynaptic NMDA receptor signalling: implications for neurodegenerative disorders
GE Hardingham, H Bading
Nature Reviews Neuroscience 11 (10), 682-696, 2010
Distinct functions of nuclear and cytoplasmic calcium in the control of gene expression
GE Hardingham, S Chawla, CM Johnson, H Bading
Nature 385 (6613), 260-265, 1997
The Yin and Yang of NMDA receptor signalling
GE Hardingham, H Bading
Trends in neurosciences 26 (2), 81-89, 2003
Nuclear calcium signaling controls CREB-mediated gene expression triggered by synaptic activity
GE Hardingham, FJL Arnold, H Bading
Nature neuroscience 4 (3), 261-267, 2001
Synaptic NMDA receptor activity boosts intrinsic antioxidant defenses
S Papadia, FX Soriano, F Léveillé, MA Martel, KA Dakin, HH Hansen, ...
Nature neuroscience 11 (4), 476-487, 2008
CBP: a signal-regulated transcriptional coactivator controlled by nuclear calcium and CaM kinase IV
S Chawla, GE Hardingham, DR Quinn, H Bading
Science 281 (5382), 1505-1509, 1998
Mutant induced pluripotent stem cell lines recapitulate aspects of TDP-43 proteinopathies and reveal cell-specific vulnerability
B Bilican, A Serio, SJ Barmada, AL Nishimura, GJ Sullivan, M Carrasco, ...
Proceedings of the National Academy of Sciences 109 (15), 5803-5808, 2012
A calcium microdomain near NMDA receptors: on switch for ERK-dependent synapse-to-nucleus communication
GE Hardingham, FJL Arnold, H Bading
Nature neuroscience 4 (6), 565-566, 2001
Control of recruitment and transcription-activating function of CBP determines gene regulation by NMDA receptors and L-type calcium channels
GE Hardingham, S Chawla, FH Cruzalegui, H Bading
Neuron 22 (4), 789-798, 1999
Nuclear Ca2+ and the cAMP response element-binding protein family mediate a late phase of activity-dependent neuroprotection
S Papadia, P Stevenson, NR Hardingham, H Bading, GE Hardingham
Journal of Neuroscience 25 (17), 4279-4287, 2005
Coupling of the NMDA receptor to neuroprotective and neurodestructive events
GE Hardingham
Biochemical Society Transactions 37 (6), 1147-1160, 2009
Linking early-life NMDAR hypofunction and oxidative stress in schizophrenia pathogenesis
GE Hardingham, KQ Do
Nature Reviews Neuroscience 17 (2), 125-134, 2016
Preconditioning doses of NMDA promote neuroprotection by enhancing neuronal excitability
FX Soriano, S Papadia, F Hofmann, NR Hardingham, H Bading, ...
Journal of Neuroscience 26 (17), 4509-4518, 2006
Influence of GluN2 subunit identity on NMDA receptor function
DJA Wyllie, MR Livesey, GE Hardingham
Neuropharmacology 74, 4-17, 2013
Mitochondrial calcium uniporter Mcu controls excitotoxicity and is transcriptionally repressed by neuroprotective nuclear calcium signals
J Qiu, YW Tan, AM Hagenston, MA Martel, N Kneisel, PA Skehel, ...
Nature communications 4 (1), 2034, 2013
Neurons and neuronal activity control gene expression in astrocytes to regulate their development and metabolism
P Hasel, O Dando, Z Jiwaji, P Baxter, AC Todd, S Heron, NM Márkus, ...
Nature communications 8 (1), 15132, 2017
Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated
GE Hardingham, H Bading
Biochimica Et Biophysica Acta (BBA)-Proteins and Proteomics 1600 (1-2), 148-153, 2002
The dichotomy of NMDA receptor signaling
S Papadia, GE Hardingham
The Neuroscientist 13 (6), 572-579, 2007
Adaptive regulation of the brain’s antioxidant defences by neurons and astrocytes
PS Baxter, GE Hardingham
Free Radical Biology and Medicine 100, 147-152, 2016
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