Caroline Heckman
Caroline Heckman
University of Helsinki, Institute for Molecular Medicine Finland FIMM-HiLIFE
Verified email at helsinki.fi - Homepage
TitleCited byYear
Somatic STAT3 Mutations in Large Granular Lymphocytic Leukemia
HLM Koskela, S Eldfors, P Ellonen, AJ van Adrichem, H Kuusanmäki, ...
New England Journal of Medicine 366 (20), 1905-1913, 2012
4652012
Functional interaction of VEGF-C and VEGF-D with neuropilin receptors
T Kärpänen, CA Heckman, S Keskitalo, M Jeltsch, H Ollila, G Neufeld, ...
The FASEB Journal 20 (9), 1462-1472, 2006
3152006
Histone deacetylase inhibitors down-regulate bcl-2 expression and induce apoptosis in t (14; 18) lymphomas
H Duan, CA Heckman, LM Boxer
Molecular and cellular biology 25 (5), 1608-1619, 2005
2672005
Negative regulation of bcl-2 expression by p53 in hematopoietic cells
Y Wu, JW Mehew, CA Heckman, M Arcinas, LM Boxer
Oncogene 20 (2), 240, 2001
2562001
Comparison of solution-based exome capture methods for next generation sequencing
AM Sulonen, P Ellonen, H Almusa, M Lepistö, S Eldfors, S Hannula, ...
Genome biology 12 (9), R94, 2011
2352011
NF-κB activates Bcl-2 expression in t (14; 18) lymphoma cells
CA Heckman, JW Mehew, LM Boxer
Oncogene 21 (24), 3898, 2002
2122002
Individualized systems medicine strategy to tailor treatments for patients with chemorefractory acute myeloid leukemia
T Pemovska, M Kontro, B Yadav, H Edgren, S Eldfors, A Szwajda, ...
Cancer discovery 3 (12), 1416-1429, 2013
202*2013
Use of cancer‐specific genomic rearrangements to quantify disease burden in plasma from patients with solid tumors
DJ McBride, AK Orpana, C Sotiriou, H Joensuu, PJ Stephens, LJ Mudie, ...
Genes, Chromosomes and Cancer 49 (11), 1062-1069, 2010
1962010
Discovery of somatic STAT5b mutations in large granular lymphocytic leukemia
HLM Rajala, S Eldfors, H Kuusanmäki, AJ Van Adrichem, T Olson, ...
Blood 121 (22), 4541-4550, 2013
1792013
Quantitative scoring of differential drug sensitivity for individually optimized anticancer therapies
B Yadav, T Pemovska, A Szwajda, E Kulesskiy, M Kontro, R Karjalainen, ...
Scientific reports 4, 5193, 2014
1092014
The tyrosine kinase inhibitor cediranib blocks ligand-induced vascular endothelial growth factor receptor-3 activity and lymphangiogenesis
CA Heckman, T Holopainen, M Wirzenius, S Keskitalo, M Jeltsch, ...
Cancer Research 68 (12), 4754-4762, 2008
1042008
The WT1 Protein Is a Negative Regulator of the Normalbcl-2 Allele in t (14; 18) Lymphomas
C Heckman, E Mochon, M Arcinas, LM Boxer
Journal of Biological Chemistry 272 (31), 19609-19614, 1997
941997
A-Myb up-regulates Bcl-2 through a Cdx binding site in t (14; 18) lymphoma cells
CA Heckman, JW Mehew, GG Ying, M Introna, J Golay, LM Boxer
Journal of Biological Chemistry 275 (9), 6499-6508, 2000
722000
Molecular mechanisms of transcriptional control of bcl-2 and c-myc in follicular and transformed lymphoma
M Arcinas, CA Heckman, JW Mehew, LM Boxer
Cancer research 61 (13), 5202-5206, 2001
642001
Novel activating STAT5B mutations as putative drivers of T-cell acute lymphoblastic leukemia
M Kontro, H Kuusanmäki, S Eldfors, T Burmeister, EI Andersson, ...
Leukemia 28 (8), 1738, 2014
612014
CCAAT/enhancer binding protein α (C/EBPα) and C/EBPα myeloid oncoproteins induce bcl-2 via interaction of their basic regions with nuclear factor-κB p50
I Paz-Priel, DH Cai, D Wang, J Kowalski, A Blackford, H Liu, CA Heckman, ...
Molecular Cancer Research 3 (10), 585-596, 2005
582005
Regulation of Bcl-2 expression by C/EBP in t (14; 18) lymphoma cells
CA Heckman, MA Wheeler, LM Boxer
Oncogene 22 (39), 7891, 2003
442003
Novel somatic mutations in large granular lymphocytic leukemia affecting the STAT-pathway and T-cell activation
EI Andersson, HLM Rajala, S Eldfors, P Ellonen, T Olson, A Jerez, ...
Blood cancer journal 3 (12), e168, 2013
422013
Oct transcription factors mediate t(14;18) lymphoma cell survival by directly regulating bcl-2 expression
CA Heckman, H Duan, PB Garcia, LM Boxer
Oncogene 25 (6), 888, 2006
412006
HOX gene expression predicts response to BCL-2 inhibition in acute myeloid leukemia
M Kontro, A Kumar, MM Majumder, S Eldfors, A Parsons, T Pemovska, ...
Leukemia 31 (2), 301, 2017
362017
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