A comprehensive panel of three-dimensional models for studies of prostate cancer growth, invasion and drug responses V Härmä, J Virtanen, R Mäkelä, A Happonen, JP Mpindi, M Knuuttila, ... PloS one 5 (5), e10431, 2010 | 415 | 2010 |
Systematic knockdown of epigenetic enzymes identifies a novel histone demethylase PHF8 overexpressed in prostate cancer with an impact on cell proliferation, migration and invasion M Björkman, P Östling, V Härmä, J Virtanen, JP Mpindi, J Rantala, T Mirtti, ... Oncogene 31 (29), 3444-3456, 2012 | 128 | 2012 |
Quantification of dynamic morphological drug responses in 3D organotypic cell cultures by automated image analysis V Härmä, HP Schukov, A Happonen, I Ahonen, J Virtanen, H Siitari, ... PloS one 9 (5), e96426, 2014 | 95 | 2014 |
Lysophosphatidic acid and sphingosine-1-phosphate promote morphogenesis and block invasion of prostate cancer cells in three-dimensional organotypic models V Härmä, M Knuuttila, J Virtanen, T Mirtti, P Kohonen, P Kovanen, ... Oncogene 31 (16), 2075-2089, 2012 | 51 | 2012 |
Direct transfection of clonal organoids in Matrigel microbeads: a promising approach toward organoid-based genetic screens B Laperrousaz, S Porte, S Gerbaud, V Härmä, F Kermarrec, V Hourtane, ... Nucleic acids research 46 (12), e70-e70, 2018 | 47 | 2018 |
Automated tracking of tumor-stroma morphology in microtissues identifies functional targets within the tumor microenvironment for therapeutic intervention M Åkerfelt, N Bayramoglu, S Robinson, M Toriseva, HP Schukov, ... Oncotarget 6 (30), 30035, 2015 | 42 | 2015 |
Optimization of invasion-specific effects of betulin derivatives on prostate cancer cells through lead development V Härmä, R Haavikko, J Virtanen, I Ahonen, HP Schukov, S Alakurtti, ... PLoS One 10 (5), e0126111, 2015 | 33 | 2015 |
Image-based ex vivo drug screen to assess targeted therapies in recurrent thymoma A Arjonen, R Mäkelä, V Härmä, N Rintanen, T Kuopio, J Kononen, ... Lung Cancer 145, 27-32, 2020 | 20 | 2020 |
Ex vivo modelling of drug efficacy in a rare metastatic urachal carcinoma R Mäkelä, A Arjonen, V Härmä, N Rintanen, L Paasonen, T Paprotka, ... BMC cancer 20, 1-10, 2020 | 12 | 2020 |
Ex vivo assessment of targeted therapies in a rare metastatic epithelial–myoepithelial carcinoma R Mäkelä, A Arjonen, AS Rahmanto, V Härmä, J Lehtiö, T Kuopio, ... Neoplasia 22 (9), 390-398, 2020 | 12 | 2020 |
Morphological clustering of cell cultures based on size, shape, and texture features I Ahonen, V Härmä, HP Schukov, M Nees, J Nevalainen Statistics in Biopharmaceutical Research 8 (2), 217-228, 2016 | 7 | 2016 |
Defined extracellular matrix compositions support stiffness-insensitive cell spreading and adhesion signaling JRW Conway, A Isomursu, G Follain, V Härmä, E Jou-Ollé, N Pasquier, ... Proceedings of the National Academy of Sciences 120 (43), e2304288120, 2023 | 5 | 2023 |
Ex Vivo Drug Screening Informed Targeted Therapy for Metastatic Parotid Squamous Cell Carcinoma N Nykänen, R Mäkelä, A Arjonen, V Härmä, L Lewandowski, E Snowden, ... Frontiers in Oncology 11, 735820, 2021 | 4 | 2021 |
Ex vivo analysis of DNA repair targeting in extreme rare cutaneous apocrine sweat gland carcinoma R Mäkelä, V Härmä, NB Fajardo, G Wells, Z Lygerou, O Sangfelt, ... Oncotarget 12 (11), 1100, 2021 | 4 | 2021 |
VTT-006, an anti-mitotic compound, binds to the Ndc80 complex and suppresses cancer cell growth in vitro LJ Laine, JHE Mäki-Jouppila, E Kutvonen, P Tiikkainen, TKM Nyholm, ... Oncoscience 8, 134, 2021 | 1 | 2021 |
A Farewell to Flat Biology V Härmä Turku: Turun Yliopisto, 2012 | 1 | 2012 |
Advanced Models for Target Validation & Drug Discovery in Prostate Cancer M Åkerfelt, V Härmä, M Nees Prostate Cancer-From Bench to Bedside, 2011 | 1 | 2011 |
Science Repository A Arjonen, R Mäkelä, R Virtakoivu, V Härmä, T Kuopio, H Hakkarainen, ... | | 2020 |
Betulins as novel lead compounds for cancer KM Oksman-Caldentey, M Lämsä, V Härmä, R Haavikko, S Alakurtti, ... Challenges and prospects in PNP metabolic engineering and production: Final …, 2015 | | 2015 |
A Farewell to Flat Biology. Three-dimensional Cell Culture Models in Cancer Drug Target Identification and Validation V Härmä Annales Universitatis Turkuensis D 1028, 2012 | | 2012 |