Eric Dean Watt

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Richard JudsonUS EPA, Center for Computational Toxicology and ExposureVerified email at epa.gov
Keith A HouckUS EPA, Center for Computational Toxicology and ExposureVerified email at epa.gov
Hashim M Al-HashimiColumbia UniversityVerified email at cumc.columbia.edu
Russell S ThomasDirector, Center for Computational Toxicology and Exposure, U.S. Environmental Protection AgencyVerified email at epa.gov
Matthew Martin (0000-0002-8096-9908)Drug Safety Research and Development, Pfizer Inc.Verified email at pfizer.com
Steven O. SimmonsUS EPA Office of Research and DevelopmentVerified email at epa.gov
Rebecca BerlowUniversity of North Carolina at Chapel HillVerified email at med.unc.edu
Nicole KleinstreuerNICEATM DirectorVerified email at nih.gov
Chad RienstraU. Wisconsin-Madison, NMRFAM, BMRBVerified email at wisc.edu
Andrei AlexandrescuUniversity of ConnecticutVerified email at uconn.edu
Emma V. Watson, Ph.D.UMass Chan Medical SchoolVerified email at umassmed.edu
Nicolas DoucetCentre Armand-Frappier Santé Biotechnologie, INRS, Université du QuébecVerified email at inrs.ca
Alexandar L HansenOhio State University, CCIC & Gateway NMR FacilitiesVerified email at osu.edu
Catherine MusselmanAssociate Professor Biochemistry, University of Colorado Anschutz Medical CampusVerified email at cuanschutz.edu
James H. MorrisseyProfessor of Biological Chemistry, University of Michigan Medical SchoolVerified email at umich.edu
Sean WhittierPostdoctoral Fellow, UT Southwestern Medical CenterVerified email at utsouthwestern.edu
Ivan RivaltaAlma Mater Studiorium - Università di BolognaVerified email at unibo.it
Gemma ComellasPhD, Biophysics and Computational Biology, University of Illinois at Urbana-ChampaignVerified email at amazon.com
Lindsay J. SperlingSanta Clara UniversityVerified email at scu.edu
Marcus TuttlePost Doctoral Associate, Yale UniversityVerified email at yale.edu

Eric Dean Watt

Pfizer

Verified email at pfizer.com - Homepage

Computational Toxicology ADMET


Title Sort by citations Sort by year Sort by title	Cited by Cited by	Year
Resolving the motional modes that code for RNA adaptation Q Zhang, X Sun, ED Watt, HM Al-Hashimi Science 311 (5761), 653-656, 2006	267	2006
Characterization of enzyme motions by solution NMR relaxation dispersion JP Loria, RB Berlow, ED Watt Accounts of chemical research 41 (2), 214-221, 2008	202	2008
The mechanism of rate-limiting motions in enzyme function ED Watt, H Shimada, EL Kovrigin, JP Loria Proceedings of the National Academy of Sciences 104 (29), 11981-11986, 2007	194	2007
Development and validation of a computational model for androgen receptor activity NC Kleinstreuer, P Ceger, ED Watt, M Martin, K Houck, P Browne, ... Chemical research in toxicology 30 (4), 946-964, 2017	184	2017
Hydrogen exchange of monomeric α‐synuclein shows unfolded structure persists at physiological temperature and is independent of molecular crowding in Escherichia coli RL Croke, CO Sallum, E Watson, ED Watt, AT Alexandrescu Protein Science 17 (8), 1434-1445, 2008	118	2008
Tiered high-throughput screening approach to identify thyroperoxidase inhibitors within the ToxCast Phase I and II chemical libraries K Paul Friedman, ED Watt, MW Hornung, JM Hedge, RS Judson, ... Toxicological Sciences 151 (1), 160-180, 2016	116	2016
The flexibility of a distant loop modulates active site motion and product release in ribonuclease A N Doucet, ED Watt, JP Loria Biochemistry 48 (30), 7160-7168, 2009	93	2009
Characterizing complex dynamics in the transactivation response element apical loop and motional correlations with the bulge by NMR, molecular dynamics, and mutagenesis EA Dethoff, AL Hansen, C Musselman, ED Watt, I Andricioaei, ... Biophysical journal 95 (8), 3906-3915, 2008	87	2008
On selecting a minimal set of in vitro assays to reliably determine estrogen agonist activity RS Judson, KA Houck, ED Watt, RS Thomas Regulatory Toxicology and Pharmacology 91, 39-49, 2017	46	2017
Uncertainty quantification in ToxCast high throughput screening ED Watt, RS Judson PLoS One 13 (7), e0196963, 2018	45	2018
Recent Advances in Solid-State Nuclear Magnetic Resonance Techniques to Quantify Biomolecular Dynamics ED Watt, CM Rienstra Analytical chemistry 86 (1), 58-64, 2013	23	2013
QSAR models for thyroperoxidase inhibition and screening of US and EU chemical inventories SA Rosenberg, ED Watt, RS Judson, SO Simmons, KP Friedman, ... Computational Toxicology 4, 11-21, 2017	22	2017
Reengineering rate-limiting, millisecond enzyme motions by introduction of an unnatural amino acid ED Watt, I Rivalta, SK Whittier, VS Batista, JP Loria Biophysical journal 101 (2), 411-420, 2011	16	2011
Experimental Protein Structure Verification by Scoring with a Single, Unassigned NMR Spectrum JM Courtney, Q Ye, AE Nesbitt, M Tang, MD Tuttle, ED Watt, KM Nuzzio, ... Structure 23 (10), 1958-1966, 2015	11	2015
Characterization of a high throughput human stem cell cardiomyocyte assay to predict drug-induced changes in clinical electrocardiogram parameters P Kilfoil, SL Feng, A Bassyouni, T Lee, D Leishman, D Li, DJ MacEwan, ... European Journal of Pharmacology 912, 174584, 2021	7	2021
Early Drug-Induced Liver Injury (DILI) Risk Screening:“Free”, as good as it gets MT Martin, P Koza-Taylor, L Di, ED Watt, C Keefer, D Smaltz, J Cook, ... Toxicological Sciences, 2022	5	2022
High-resolution NMR studies of human tissue factor KM Nuzzio, ED Watt, JM Boettcher, JM Gajsiewicz, JH Morrissey, ... PloS one 11 (9), e0163206, 2016	4	2016
Biomolecular NMR: Isotope Labeling Methods for Protein Dynamics Studies ED Watt, JP Loria	1
Use of high throughput ion channel profiling and statistical modeling to predict off-target arrhythmia risk-One pharma's experience and perspective ED Watt, T Lee, SL Feng, P Kilfoil, D Ackley, C Keefer, T Wisialowski, ... Journal of Pharmacological and Toxicological Methods 118, 107213, 2022		2022
The Mechanism and Modulation of Rate-limiting Millisecond Enzyme Motions in Ribonuclease A ED Watt Yale University, 2012		2012

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