Avital Swisa
Avital Swisa
Postdoctoral fellow at the Kaestner lab, University of Pennsylvania
Vahvistettu sähköpostiosoite verkkotunnuksessa
p16Ink4a-induced senescence of pancreatic beta cells enhances insulin secretion
A Helman, A Klochendler, N Azazmeh, Y Gabai, E Horwitz, S Anzi, ...
Nature medicine 22 (4), 412-420, 2016
Small extracellular vesicles are key regulators of non-cell autonomous intercellular communication in senescence via the interferon protein IFITM3
M Borghesan, J Fafián-Labora, O Eleftheriadou, P Carpintero-Fernández, ...
Cell Reports 27 (13), 3956-3971. e6, 2019
LKB1 regulates pancreatic β cell size, polarity, and function
Z Granot, A Swisa, J Magenheim, M Stolovich-Rain, W Fujimoto, ...
Cell metabolism 10 (4), 296-308, 2009
Pancreatic LKB1 deletion leads to acinar polarity defects and cystic neoplasms
AF Hezel, S Gurumurthy, Z Granot, A Swisa, GC Chu, G Bailey, Y Dor, ...
Molecular and cellular biology 28 (7), 2414-2425, 2008
Metabolic stress and compromised identity of pancreatic beta cells
A Swisa, B Glaser, Y Dor
Frontiers in genetics 8, 246813, 2017
PAX6 maintains β cell identity by repressing genes of alternative islet cell types
A Swisa, D Avrahami, N Eden, J Zhang, E Feleke, T Dahan, ...
The Journal of clinical investigation 127 (1), 230-243, 2017
AMPK regulates ER morphology and function in stressed pancreatic β-cells via phosphorylation of DRP1
JD Wikstrom, T Israeli, E Bachar-Wikstrom, A Swisa, Y Ariav, M Waiss, ...
Molecular endocrinology 27 (10), 1706-1723, 2013
mTORC1-to-AMPK switching underlies β cell metabolic plasticity during maturation and diabetes
R Jaafar, S Tran, AN Shah, G Sun, M Valdearcos, P Marchetti, M Masini, ...
The Journal of clinical investigation 129 (10), 4124-4137, 2019
Phosphorylation of ribosomal protein S6 attenuates DNA damage and tumor suppression during development of pancreatic cancer
A Khalaileh, A Dreazen, A Khatib, R Apel, A Swisa, N Kidess-Bassir, ...
Cancer research 73 (6), 1811-1820, 2013
LKB1 and AMPK differentially regulate pancreatic β-cell identity
M Kone, TJ Pullen, G Sun, M Ibberson, A Martinez-Sanchez, S Sayers, ...
The FASEB Journal 28 (11), 4972, 2014
Dynamical compensation in physiological circuits
O Karin, A Swisa, B Glaser, Y Dor, U Alon
Molecular systems biology 12 (11), 886, 2016
A transgenic mouse marking live replicating cells reveals in vivo transcriptional program of proliferation
A Klochendler, N Weinberg-Corem, M Moran, A Swisa, N Pochet, ...
Developmental cell 23 (4), 681-690, 2012
Pancreatic β-cells express the fetal islet hormone gastrin in rodent and human diabetes
T Dahan, O Ziv, E Horwitz, H Zemmour, J Lavi, A Swisa, G Leibowitz, ...
Diabetes 66 (2), 426-436, 2017
Loss of liver kinase B1 (LKB1) in beta cells enhances glucose-stimulated insulin secretion despite profound mitochondrial defects
A Swisa, Z Granot, N Tamarina, S Sayers, N Bardeesy, L Philipson, ...
Journal of Biological Chemistry 290 (34), 20934-20946, 2015
β-Cell DNA damage response promotes islet inflammation in type 1 diabetes
E Horwitz, L Krogvold, S Zhitomirsky, A Swisa, M Fischman, T Lax, ...
Diabetes 67 (11), 2305-2318, 2018
Conditional hypovascularization and hypoxia in islets do not overtly influence adult β-cell mass or function
J D'Hoker, N De Leu, Y Heremans, L Baeyens, K Minami, C Ying, ...
Diabetes 62 (12), 4165-4173, 2013
Short-term overexpression of VEGF-A in mouse beta cells indirectly stimulates their proliferation and protects against diabetes
N De Leu, Y Heremans, V Coppens, N Van Gassen, Y Cai, J D’hoker, ...
Diabetologia 57, 140-147, 2014
Determinants of pancreatic β‐cell regeneration
A Khalaileh, T Gonen‐Gross, J Magenheim, T Nir, S Porat, S Salpeter, ...
Diabetes, Obesity and Metabolism 10, 128-135, 2008
Transcriptional noise and somatic mutations in the aging pancreas
A Swisa, KH Kaestner, Y Dor
Cell Metabolism 26 (6), 809-811, 2017
miR-17-92 and miR-106b-25 clusters regulate beta cell mitotic checkpoint and insulin secretion in mice
AD Mandelbaum, S Kredo-Russo, D Aronowitz, N Myers, E Yanowski, ...
Diabetologia 62, 1653-1666, 2019
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Artikkelit 1–20