Antti Poso
Antti Poso
Professor of Drug Design, University of Eastern Finland
Vahvistettu sähköpostiosoite verkkotunnuksessa
Characterization of the sulfhydryl-sensitive site in the enzyme responsible for hydrolysis of 2-arachidonoyl-glycerol in rat cerebellar membranes
SM Saario, OMH Salo, T Nevalainen, A Poso, JT Laitinen, T Järvinen, ...
Chemistry & biology 12 (6), 649-656, 2005
An in silico approach to discovering novel inhibitors of human sirtuin type 2
AJ Tervo, S Kyrylenko, P Niskanen, A Salminen, J Leppänen, TH Nyrönen, ...
Journal of medicinal chemistry 47 (25), 6292-6298, 2004
A MYC–aurora kinase A protein complex represents an actionable drug target in p53-altered liver cancer
D Dauch, R Rudalska, G Cossa, JC Nault, TW Kang, T Wuestefeld, ...
Nature medicine 22 (7), 744, 2016
Development of a 3D model for the human cannabinoid CB1 receptor
OMH Salo, M Lahtela-Kakkonen, J Gynther, T Järvinen, A Poso
Journal of medicinal chemistry 47 (12), 3048-3057, 2004
Predictive three-dimensional quantitative structure− activity relationship of cytochrome P450 1A2 inhibitors
LE Korhonen, M Rahnasto, NJ Mähönen, C Wittekindt, A Poso, ...
Journal of medicinal chemistry 48 (11), 3808-3815, 2005
Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors
T Huhtiniemi, T Suuronen, VM Rinne, C Wittekindt, M Lahtela-Kakkonen, ...
Journal of medicinal chemistry 51 (15), 4377-4380, 2008
Prediction of human population responses to toxic compounds by a collaborative competition.
Nature Biotechnology 33, 933-940, 2015
Targeting the cannabinoid CB2 receptor: mutations, modeling and development of CB2 selective ligands
KH Raitio, OMH Salo, T Nevalainen, A Poso, T Jarvinen
Current medicinal chemistry 12 (10), 1217-1237, 2005
A rhodopsin-based model for melatonin recognition at its G protein-coupled receptor
C Navajas, T Kokkola, A Poso, N Honka, J Gynther, JT Laitinen
European journal of pharmacology 304 (1-3), 173-183, 1996
Targeting the cannabinoid CB2 receptor: modelling and structural determinants of CB2 selective ligands
A Poso, JW Huffman
British journal of pharmacology 153 (2), 335-346, 2008
Fatty acid amide hydrolase inhibitors from virtual screening of the endocannabinoid system
SM Saario, A Poso, RO Juvonen, T Järvinen, OMH Salo-Ahen
Journal of medicinal chemistry 49 (15), 4650-4656, 2006
Virtual screening of novel CB2 ligands using a comparative model of the human cannabinoid CB2 receptor
OMH Salo, KH Raitio, JR Savinainen, T Nevalainen, M Lahtela-Kakkonen, ...
Journal of medicinal chemistry 48 (23), 7166-7171, 2005
A comparative molecular field analysis of cytochrome P450 2A5 and 2A6 inhibitors
A Poso, J Gynther, R Juvonen
Journal of computer-aided molecular design 15 (3), 195-202, 2001
Piperazine and piperidine triazole ureas as ultrapotent and highly selective inhibitors of monoacylglycerol lipase
N Aaltonen, JR Savinainen, CR Ribas, J Rönkkö, A Kuusisto, J Korhonen, ...
Chemistry & biology 20 (3), 379-390, 2013
Drug release from starch-acetate microparticles and films with and without incorporated α-amylase
L Tuovinen, S Peltonen, M Liikola, M Hotakainen, M Lahtela-Kakkonen, ...
Biomaterials 25 (18), 4355-4362, 2004
Discovery of boronic acids as novel and potent inhibitors of fatty acid amide hydrolase
A Minkkila, SM Saario, H Käsnänen, J Leppänen, A Poso, ...
Journal of medicinal chemistry 51 (22), 7057-7060, 2008
N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors
PH Kiviranta, J Leppänen, VM Rinne, T Suuronen, O Kyrylenko, ...
Bioorganic & medicinal chemistry letters 17 (9), 2448-2451, 2007
Discovery of salermide-related sirtuin inhibitors: binding mode studies and antiproliferative effects in cancer cells including cancer stem cells
D Rotili, D Tarantino, A Nebbioso, C Paolini, C Huidobro, E Lara, P Mellini, ...
Journal of medicinal chemistry 55 (24), 10937-10947, 2012
Amino acids important for ligand specificity of the human constitutive androstane receptor
J Jyrkkärinne, B Windshügel, J Mäkinen, M Ylisirniö, M Peräkylä, A Poso, ...
Journal of Biological Chemistry 280 (7), 5960-5971, 2005
Synthesis and SAR studies of 2-oxoquinoline derivatives as CB2 receptor inverse agonists
KH Raitio, JR Savinainen, J Vepsäläinen, JT Laitinen, A Poso, T Järvinen, ...
Journal of medicinal chemistry 49 (6), 2022-2027, 2006
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Artikkelit 1–20