Rui M M Brito
Rui M M Brito
Associate Professor, Chemistry Department, University of Coimbra
Verified email at - Homepage
Cited by
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Tetramer dissociation and monomer partial unfolding precedes protofibril formation in amyloidogenic transthyretin variants
A Quintas, DC Vaz, I Cardoso, MJM Saraiva, RMM Brito
Journal of Biological Chemistry 276 (29), 27207-27213, 2001
Determination of the critical micelle concentration of surfactants using the fluorescent probe N-phenyl-1-naphthylamine
RMM Brito, WLC Vaz
Analytical biochemistry 152 (2), 250-255, 1986
The tetrameric protein transthyretin dissociates to a non-native monomer in solution: a novel model for amyloidogenesis
A Quintas, MJM Saraiva, RMM Brito
Journal of Biological Chemistry 274 (46), 32943-32949, 1999
The amyloidogenic potential of transthyretin variants correlates with their tendency to aggregate in solution
A Quintas, MJM Saraiva, RMM Brito
Febs Letters 418 (3), 297-300, 1997
The saposin-like domain of the plant aspartic proteinase precursor is a potent inducer of vesicle leakage
C Egas, N Lavoura, R Resende, RMM Brito, E Pires, MCP de Lima, ...
Journal of Biological Chemistry 275 (49), 38190-38196, 2000
Solution Structures of the C-Terminal Domain of Cardiac Troponin C Free and Bound to the N-Terminal Domain of Cardiac Troponin I,
GMC Gasmi-Seabrook, JW Howarth, N Finley, E Abusamhadneh, ...
Biochemistry 38 (26), 8313-8322, 1999
Structural characterization of the minimal segment of TDP-43 competent for aggregation
M MompeŠn, E Buratti, C Guarnaccia, RMM Brito, A Chakrabartty, ...
Archives of biochemistry and biophysics 545, 53-62, 2014
Mining approximate motifs in time series
PG Ferreira, PJ Azevedo, CG Silva, RMM Brito
International Conference on Discovery Science, 89-101, 2006
Evaluation by fluorescence, STD-NMR, docking and semi-empirical calculations of the o-NBA photo-acid interaction with BSA
OA Chaves, CSH Jesus, PF Cruz, CMR Sant'Anna, RMM Brito, C Serpa
Spectrochimica Acta Part A: Molecular and Biomolecular Spectroscopy 169, 175-181, 2016
Comparative calorimetric study of non-amyloidogenic and amyloidogenic variants of the homotetrameric protein transthyretin
VL Shnyrov, E Villar, GG Zhadan, JM Sanchez-Ruiz, A Quintas, ...
Biophysical chemistry 88 (1-3), 61-67, 2000
Enthalpic and entropic contributions mediate the role of disulfide bonds on the conformational stability of Interleukin‐4
DC Vaz, JR Rodrigues, W Sebald, CM Dobson, RMM Brito
Protein science 15 (1), 33-44, 2006
The low-affinity Ca2 (+)-binding sites in cardiac/slow skeletal muscle troponin C perform distinct functions: site I alone cannot trigger contraction
HL Sweeney, RM Brito, PR Rosevear, JA Putkey
Proceedings of the National Academy of Sciences 87 (24), 9538-9542, 1990
Conformational changes in the metal-binding sites of cardiac troponin C induced by calcium binding
GA Krudy, RMM Brito, JA Putkey, PR Rosevear
Biochemistry 31 (6), 1595-1602, 1992
Amyloid formation by transthyretin: from protein stability to protein aggregation
RMM Brito, AM Damas, MJ Saraiva
Current Medicinal Chemistry-Immunology, Endocrine & Metabolic Agents 3 (4†…, 2003
A look into amyloid formation by transthyretin: aggregation pathway and a novel kinetic model
TQ Faria, ZL Almeida, PF Cruz, CSH Jesus, P Castanheira, RMM Brito
Physical Chemistry Chemical Physics 17 (11), 7255-7263, 2015
Structure and aggregation mechanisms in amyloids
ZL Almeida, RMM Brito
Molecules 25 (5), 1195, 2020
Changes in channel trafficking and protein stability caused by LQT2 mutations in the PAS domain of the HERG channel
CA Harley, CSH Jesus, R Carvalho, RMM Brito, JH Morais-Cabral
PLoS One 7 (3), e32654, 2012
Biological activity of heterologous murine interleukin-10 and preliminary studies on the use of a dextrin nanogel as a delivery system
V Carvalho, P Castanheira, TQ Faria, C GonÁalves, P Madureira, C Faro, ...
International journal of pharmaceutics 400 (1-2), 234-242, 2010
Potentially amyloidogenic conformational intermediates populate the unfolding landscape of transthyretin: insights from molecular dynamics simulations
JR Rodrigues, CJV Siműes, CG Silva, RMM Brito
Protein science 19 (2), 202-219, 2010
The apoptogenic toxin AIP56 is a metalloprotease AB toxin that cleaves NF-κb P65
DS Silva, LMG Pereira, AR Moreira, F Ferreira-da-Silva, RM Brito, ...
PLoS pathogens 9 (2), e1003128, 2013
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