| Phenyliodine bis (trifluoroacetate)-mediated oxidative C–C bond formation: synthesis of 3-hydroxy-2-oxindoles and spirooxindoles from anilides J Wang, Y Yuan, R Xiong, D Zhang-Negrerie, Y Du, K Zhao Organic letters 14 (9), 2210-2213, 2012 | 143 | 2012 |
| Design of SARS-CoV-2 PLpro inhibitors for COVID-19 antiviral therapy leveraging binding cooperativity Z Shen, K Ratia, L Cooper, D Kong, H Lee, Y Kwon, Y Li, S Alqarni, ... Journal of medicinal chemistry 65 (4), 2940-2955, 2021 | 123 | 2021 |
| Novel selective estrogen receptor downregulators (SERDs) developed against treatment-resistant breast cancer R Xiong, J Zhao, LM Gutgesell, Y Wang, S Lee, B Karumudi, H Zhao, Y Lu, ... Journal of medicinal chemistry 60 (4), 1325-1342, 2017 | 87 | 2017 |
| Selective human estrogen receptor partial agonists (ShERPAs) for tamoxifen-resistant breast cancer R Xiong, HK Patel, LM Gutgesell, J Zhao, L Delgado-Rivera, TND Pham, ... Journal of medicinal chemistry 59 (1), 219-237, 2016 | 65 | 2016 |
| Novel and potent inhibitors targeting DHODH, a rate-limiting enzyme in de novo pyrimidine biosynthesis, are broad-spectrum antiviral against RNA viruses … R Xiong, L Zhang, S Li, Y Sun, M Ding, Y Wang, Y Zhao, Y Wu, W Shang, ... BioRxiv, 2020.03. 11.983056, 2020 | 58 | 2020 |
| G1T48, an oral selective estrogen receptor degrader, and the CDK4/6 inhibitor lerociclib inhibit tumor growth in animal models of endocrine-resistant breast cancer KJ Andreano, SE Wardell, JG Baker, TK Desautels, R Baldi, CA Chao, ... Breast cancer research and treatment 180, 635-646, 2020 | 43 | 2020 |
| Design and synthesis of basic selective estrogen receptor degraders for endocrine therapy resistant breast cancer Y Lu, LM Gutgesell, R Xiong, J Zhao, Y Li, CI Rosales, M Hollas, Z Shen, ... Journal of medicinal chemistry 62 (24), 11301-11323, 2019 | 34 | 2019 |
| Repurposing potential of 1st generation H1-specific antihistamines as anti-filovirus therapeutics A Schafer, H Cheng, R Xiong, V Soloveva, C Retterer, F Mo, S Bavari, ... Antiviral research 157, 47-56, 2018 | 30 | 2018 |
| Potent, novel SARS-CoV-2 PLpro inhibitors block viral replication in monkey and human cell cultures Z Shen, K Ratia, L Cooper, D Kong, H Lee, Y Kwon, Y Li, S Alqarni, ... BioRxiv, 2021.02. 13.431008, 2021 | 29 | 2021 |
| Identification of diaryl-quinoline compounds as entry inhibitors of Ebola virus Q Cui, H Cheng, R Xiong, G Zhang, R Du, M Anantpadma, RA Davey, ... Viruses 10 (12), 678, 2018 | 26 | 2018 |
| Novel selective estrogen mimics for the treatment of tamoxifen-resistant breast cancer ME Molloy, BEP White, T Gherezghiher, BT Michalsen, R Xiong, H Patel, ... Molecular cancer therapeutics 13 (11), 2515-2526, 2014 | 26 | 2014 |
| XP-524 is a dual-BET/EP300 inhibitor that represses oncogenic KRAS and potentiates immune checkpoint inhibition in pancreatic cancer DR Principe, R Xiong, Y Li, TND Pham, SD Kamath, O Dubrovskyi, ... Proceedings of the National Academy of Sciences 119 (4), e2116764119, 2022 | 21 | 2022 |
| Pharmacology and molecular mechanisms of clinically relevant estrogen estetrol and estrogen mimic BMI-135 for the treatment of endocrine-resistant breast cancer B Abderrahman, PY Maximov, RF Curpan, JS Hanspal, P Fan, R Xiong, ... Molecular Pharmacology 98 (4), 364-381, 2020 | 19 | 2020 |
| Novel pyrrolopyridone bromodomain and extra-terminal motif (BET) inhibitors effective in endocrine-resistant ER+ breast cancer with acquired resistance to fulvestrant and … Y Li, J Zhao, LM Gutgesell, Z Shen, K Ratia, K Dye, O Dubrovskyi, H Zhao, ... Journal of medicinal chemistry 63 (13), 7186-7210, 2020 | 19 | 2020 |
| Evidence for distinct mechanisms of small molecule inhibitors of filovirus entry A Schafer, R Xiong, L Cooper, R Nowar, H Lee, Y Li, BE Ramirez, ... PLoS Pathogens 17 (2), e1009312, 2021 | 17 | 2021 |
| Compositions and methods for treating estrogen-related medical disorders GR Thatcher, M Siklos, R Xiong US Patent App. 14/438,361, 2015 | 16 | 2015 |
| Screening and reverse-engineering of estrogen receptor ligands as potent pan-filovirus inhibitors L Cooper, A Schafer, Y Li, H Cheng, B Medegan Fagla, Z Shen, R Nowar, ... Journal of medicinal chemistry 63 (19), 11085-11099, 2020 | 13 | 2020 |
| Rapid induction of the unfolded protein response and apoptosis by estrogen mimic TTC-352 for the treatment of endocrine-resistant breast cancer B Abderrahman, PY Maximov, RF Curpan, SW Fanning, JS Hanspal, ... Molecular cancer therapeutics 20 (1), 11-25, 2021 | 11 | 2021 |
| Benzothiophene-based selective estrogen receptor downregulators GR Thatcher, R Xiong, J Zhao, DA Tonetti US Patent 10,118,910, 2018 | 9 | 2018 |
| SERMs attenuate estrogen-induced malignant transformation of human mammary epithelial cells by upregulating detoxification of oxidative metabolites LPMP Hemachandra, H Patel, REP Chandrasena, J Choi, ... Cancer Prevention Research 7 (5), 505-515, 2014 | 9 | 2014 |
Gregory ThatcherVahlteich Chair & Professor of Medicinal ChemistryVerified email at uic.edu
