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nadine hein
nadine hein
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Title
Cited by
Cited by
Year
Inhibition of RNA polymerase I as a therapeutic strategy to promote cancer-specific activation of p53
MJ Bywater, G Poortinga, E Sanij, N Hein, A Peck, C Cullinane, M Wall, ...
Cancer cell 22 (1), 51-65, 2012
5612012
The nucleolus: an emerging target for cancer therapy
N Hein, KM Hannan, AJ George, E Sanij, RD Hannan
Trends in molecular medicine 19 (11), 643-654, 2013
2622013
Phosphorylation by Cdk2 is required for Myc to repress Ras-induced senescence in cotransformation
P Hydbring, F Bahram, Y Su, S Tronnersjö, K Högstrand, N Von Der Lehr, ...
Proceedings of the National Academy of Sciences 107 (1), 58-63, 2010
2302010
Identification of Burkholderia pseudomallei Genes Required for the Intracellular Life Cycle and In Vivo Virulence
S Pilatz, K Breitbach, N Hein, B Fehlhaber, J Schulze, B Brenneke, ...
Infection and immunity 74 (6), 3576-3586, 2006
2272006
First-in-human RNA polymerase I transcription inhibitor CX-5461 in patients with advanced hematologic cancers: results of a phase I dose-escalation study
A Khot, N Brajanovski, DP Cameron, N Hein, KH Maclachlan, E Sanij, ...
Cancer discovery 9 (8), 1036-1049, 2019
1602019
Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma
JR Devlin, KM Hannan, N Hein, C Cullinane, E Kusnadi, PY Ng, ...
Cancer discovery 6 (1), 59-70, 2016
1212016
Inhibition of RNA polymerase I transcription initiation by CX-5461 activates non-canonical ATM/ATR signaling
J Quin, KT Chan, JR Devlin, DP Cameron, J Diesch, C Cullinane, J Ahern, ...
Oncotarget 7 (31), 49800, 2016
1032016
Inhibition of Pol I transcription treats murine and human AML by targeting the leukemia-initiating cell population
N Hein, DP Cameron, KM Hannan, NYN Nguyen, CY Fong, J Sornkom, ...
Blood, The Journal of the American Society of Hematology 129 (21), 2882-2895, 2017
842017
A novel role for the Pol I transcription factor UBTF in maintaining genome stability through the regulation of highly transcribed Pol II genes
E Sanij, J Diesch, A Lesmana, G Poortinga, N Hein, G Lidgerwood, ...
Genome research 25 (2), 201-212, 2015
692015
New roles for the nucleolus in health and disease
L Núñez Villacís, MS Wong, LL Ferguson, N Hein, AJ George, ...
Bioessays 40 (5), 1700233, 2018
682018
Signaling to the ribosome in cancer—It is more than just mTORC1
KM Hannan, E Sanij, N Hein, RD Hannan, RB Pearson
IUBMB life 63 (2), 79-85, 2011
562011
The nucleolus and ribosomal genes in aging and senescence
N Hein, E Sanij, J Quin, KM Hannan, A Ganley, RD Hannan
Senescence, 2012
392012
Changes in long-range rDNA-genomic interactions associate with altered RNA polymerase II gene programs during malignant transformation
J Diesch, MJ Bywater, E Sanij, DP Cameron, W Schierding, N Brajanovski, ...
Communications Biology 2 (1), 39, 2019
352019
Nuclear stabilization of p53 requires a functional nucleolar surveillance pathway
KM Hannan, P Soo, MS Wong, JK Lee, N Hein, P Poh, KD Wysoke, ...
Cell Reports 41 (5), 2022
232022
rDNA chromatin activity status as a biomarker of sensitivity to the RNA polymerase I transcription inhibitor CX-5461
J Son, KM Hannan, G Poortinga, N Hein, DP Cameron, ARD Ganley, ...
Frontiers in Cell and Developmental Biology 8, 568, 2020
202020
Role of plasma cells in Waldenström macroglobulinaemia
A El-Ayoubi, JQ Wang, N Hein, D Talaulikar
Pathology 49 (4), 337-345, 2017
192017
Advanced pancreatic ductal adenocarcinoma-Complexities of treatment and emerging therapeutic options
C Diwakarla, K Hannan, N Hein, D Yip
World journal of gastroenterology 23 (13), 2276, 2017
182017
Regulation of the MAD1 promoter by G-CSF
K Jiang, N Hein, K Eckert, J Lüscher-Firzlaff, B Lüscher
Nucleic acids research 36 (5), 1517-1531, 2008
182008
The ribosomal gene loci—the power behind the throne
KI Panov, K Hannan, RD Hannan, N Hein
Genes 12 (5), 763, 2021
172021
A phase 1, open-label, dose escalation, safety, PK and PD study of a first in class Pol1 inhibitor (CX-5461) in patients with advanced hematologic malignancies (HM).
SJ Harrison, A Khot, N Brajanovski, D Cameron, N Hein, GA McArthur, ...
Journal of Clinical Oncology 33 (15_suppl), e22212-e22212, 2015
132015
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