The role of BDNF and its receptors in depression and antidepressant drug action: reactivation of developmental plasticity E Castrén, T Rantamäki Developmental neurobiology 70 (5), 289-297, 2010 | 1095 | 2010 |
Role of neurotrophic factors in depression E Castrén, V Võikar, T Rantamäki Current opinion in pharmacology 7 (1), 18-21, 2007 | 896 | 2007 |
Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cγ signaling pathways in mouse brain T Rantamäki, P Hendolin, A Kankaanpää, J Mijatovic, P Piepponen, ... Neuropsychopharmacology 32 (10), 2152-2162, 2007 | 374 | 2007 |
Enhanced BDNF signaling is associated with an antidepressant-like behavioral response and changes in brain monoamines. E Koponen, T Rantamäki, V Voikar, T Saarelainen, E MacDonald, ... Cellular and molecular neurobiology 25 (6), 973-980, 2005 | 168 | 2005 |
Role of brain-derived neurotrophic factor in the aetiology of depression: implications for pharmacological treatment E Castrén, T Rantamäki CNS drugs 24, 1-7, 2010 | 157 | 2010 |
Antidepressant drugs transactivate TrkB neurotrophin receptors in the adult rodent brain independently of BDNF and monoamine transporter blockade T Rantamäki, L Vesa, H Antila, A Di Lieto, P Tammela, A Schmitt, ... PloS one 6 (6), e20567, 2011 | 140 | 2011 |
Cholesterol loss enhances TrkB signaling in hippocampal neurons aging in vitro MG Martin, S Perga, L Trovo, A Rasola, P Holm, T Rantamäki, T Harkany, ... Molecular Biology of the Cell 19 (5), 2101-2112, 2008 | 116 | 2008 |
The antidepressant-like effects of glutamatergic drugs ketamine and AMPA receptor potentiator LY 451646 are preserved in bdnf+/− heterozygous null mice JSO Lindholm, H Autio, L Vesa, H Antila, L Lindemann, MC Hoener, ... Neuropharmacology 62 (1), 391-397, 2012 | 112 | 2012 |
Impaired TrkB receptor signaling contributes to memory impairment in APP/PS1 mice S Kemppainen, T Rantamäki, A Jeronimo-Santos, G Lavasseur, H Autio, ... Neurobiology of aging 33 (6), 1122. e23-1122. e39, 2012 | 106 | 2012 |
BDNF and TrkB in neuronal differentiation of Fmr1-knockout mouse V Louhivuori, A Vicario, M Uutela, T Rantamäki, LM Louhivuori, E Castren, ... Neurobiology of disease 41 (2), 469-480, 2011 | 100 | 2011 |
Isoflurane produces antidepressant effects and induces TrkB signaling in rodents H Antila, M Ryazantseva, D Popova, P Sipilä, R Guirado, S Kohtala, ... Scientific reports 7 (1), 7811, 2017 | 93 | 2017 |
Modulation of BDNF cleavage by plasminogen-activator inhibitor-1 contributes to Alzheimer's neuropathology and cognitive deficits G Gerenu, E Martisova, H Ferrero, M Carracedo, T Rantamäki, ... Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1863 (4), 991 …, 2017 | 89 | 2017 |
Neurotrophins in depression and antidepressant effects E Castrén, T Rantamäki Growth Factors and Psychiatric Disorders: Novartis Foundation Symposium 289 …, 2008 | 88 | 2008 |
A role for BDNF/TrkB signaling in behavioral and physiological consequences of social defeat stress M Razzoli, E Domenici, L Carboni, T Rantamaki, J Lindholm, E Castren, ... Genes, Brain and Behavior 10 (4), 424-433, 2011 | 79 | 2011 |
VGF (TLQP-62)-induced neurogenesis targets early phase neural progenitor cells in the adult hippocampus and requires glutamate and BDNF signaling S Thakker-Varia, J Behnke, D Doobin, V Dalal, K Thakkar, F Khadim, ... Stem cell research 12 (3), 762-777, 2014 | 72 | 2014 |
Darkness reduces BDNF expression in the visual cortex and induces repressive chromatin remodeling at the BDNF gene in both hippocampus and visual cortex NN Karpova, T Rantamäki, A Di Lieto, L Lindemann, MC Hoener, ... Cellular and molecular neurobiology 30, 1117-1123, 2010 | 70 | 2010 |
The impact of Bdnf gene deficiency to the memory impairment and brain pathology of APPswe/PS1dE9 mouse model of Alzheimer’s disease T Rantamäki, S Kemppainen, H Autio, S Staven, H Koivisto, M Kojima, ... PLoS One 8 (7), e68722, 2013 | 68 | 2013 |
Acetylcholinesterase inhibitors rapidly activate Trk neurotrophin receptors in the mouse hippocampus H Autio, K Mätlik, T Rantamäki, L Lindemann, MC Hoener, M Chao, ... Neuropharmacology 61 (8), 1291-1296, 2011 | 66 | 2011 |
Alterations in BDNF and phospho-CREB levels following chronic oral nicotine treatment and its withdrawal in dopaminergic brain areas of mice T Kivinummi, K Kaste, T Rantamäki, E Castrén, L Ahtee Neuroscience letters 491 (2), 108-112, 2011 | 65 | 2011 |
Regulation of brain-derived neurotrophic factor (BDNF) and cerebral dopamine neurotrophic factor (CDNF) by anti-parkinsonian drug therapy in vivo T Gyárfás, J Knuuttila, P Lindholm, T Rantamäki, E Castrén Cellular and molecular neurobiology 30, 361-368, 2010 | 58 | 2010 |