|mTOR-dependent regulation of ribosomal gene transcription requires S6K1 and is mediated by phosphorylation of the carboxy-terminal activation domain of the nucleolar …|
KM Hannan, Y Brandenburger, A Jenkins, K Sharkey, A Cavanaugh, ...
Molecular and cellular biology 23 (23), 8862-8877, 2003
|Coordinate regulation of ribosome biogenesis and function by the ribosomal protein S6 kinase, a key mediator of mTOR function|
K Jastrzebski, KM Hannan, EB Tchoubrieva, RD Hannan, RB Pearson
Growth factors 25 (4), 209-226, 2007
|AKT induces senescence in human cells via mTORC1 and p53 in the absence of DNA damage: implications for targeting mTOR during malignancy|
MV Astle, KM Hannan, PY Ng, RS Lee, AJ George, AK Hsu, Y Haupt, ...
Oncogene 31 (15), 1949-1962, 2012
|UBF levels determine the number of active ribosomal RNA genes in mammals|
E Sanij, G Poortinga, K Sharkey, S Hung, TP Holloway, J Quin, E Robb, ...
Journal of Cell Biology 183 (7), 1259-1274, 2008
|Targeting the nucleolus for cancer intervention|
JE Quin, JR Devlin, D Cameron, KM Hannan, RB Pearson, RD Hannan
Biochimica et Biophysica Acta (BBA)-Molecular Basis of Disease 1842 (6), 802-816, 2014
|MAD1 and c‐MYC regulate UBF and rDNA transcription during granulocyte differentiation|
G Poortinga, KM Hannan, H Snelling, CR Walkley, A Jenkins, K Sharkey, ...
The EMBO journal 23 (16), 3325-3335, 2004
|The nucleolus: an emerging target for cancer therapy|
N Hein, KM Hannan, AJ George, E Sanij, RD Hannan
Trends in molecular medicine 19 (11), 643-654, 2013
|Rb and p130 regulate RNA polymerase I transcription: Rb disrupts the interaction between UBF and SL-1|
KM Hannan, RD Hannan, SD Smith, LS Jefferson, M Lun, LI Rothblum
Oncogene 19 (43), 4988-4999, 2000
|Transcription by RNA polymerase I|
KM Hannan, RD Hannan, LI Rothblum
Front Biosci 3, 376-398, 1998
|Direct identification of tyrosine 474 as a regulatory phosphorylation site for the Akt protein kinase|
NM Conus, KM Hannan, BE Cristiano, BA Hemmings, RB Pearson
Journal of Biological Chemistry 277 (41), 38021-38028, 2002
|AKT promotes rRNA synthesis and cooperates with c-MYC to stimulate ribosome biogenesis in cancer|
JC Chan, KM Hannan, K Riddell, PY Ng, A Peck, RS Lee, S Hung, ...
Science signaling 4 (188), ra56-ra56, 2011
|The nucleolus as a fundamental regulator of the p53 response and a new target for cancer therapy|
SJ Woods, KM Hannan, RB Pearson, RD Hannan
Biochimica et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1849 (7), 821-829, 2015
|Dysregulation of RNA polymerase I transcription during disease|
KM Hannan, E Sanij, LI Rothblum, RD Hannan, RB Pearson
Biochimica Et Biophysica Acta (BBA)-Gene Regulatory Mechanisms 1829 (3-4 …, 2013
|RNA polymerase I transcription in confluent cells: Rb downregulates rDNA transcription during confluence-induced cell cycle arrest|
KM Hannan, BK Kennedy, AH Cavanaugh, RD Hannan, ...
Oncogene 19 (31), 3487-3497, 2000
|A specific role for AKT3 in the genesis of ovarian cancer through modulation of G2-M phase transition|
BE Cristiano, JC Chan, KM Hannan, NA Lundie, NJ Marmy-Conus, ...
Cancer Research 66 (24), 11718-11725, 2006
|Translational control of c-MYC by rapamycin promotes terminal myeloid differentiation|
M Wall, G Poortinga, KM Hannan, RB Pearson, RD Hannan, GA McArthur
Blood, The Journal of the American Society of Hematology 112 (6), 2305-2317, 2008
|Diabetes-Induced Vascular Hypertrophy Is Accompanied by Activation of Na+-H+ Exchange and Prevented by Na+-H+ Exchange Inhibition|
K Jandeleit-Dahm, KM Hannan, CA Farrelly, TJ Allen, JR Rumble, ...
Circulation research 87 (12), 1133-1140, 2000
|Synergistic inhibition of ovarian cancer cell growth by combining selective PI3K/mTOR and RAS/ERK pathway inhibitors|
KE Sheppard, C Cullinane, KM Hannan, M Wall, J Chan, F Barber, J Foo, ...
European journal of cancer 49 (18), 3936-3944, 2013
|Combined inhibition of PI3K-related DNA damage response kinases and mTORC1 induces apoptosis in MYC-driven B-cell lymphomas|
J Shortt, BP Martin, A Newbold, KM Hannan, JR Devlin, AJ Baker, R Ralli, ...
Blood 121 (15), 2964-2974, 2013
|Combination therapy targeting ribosome biogenesis and mRNA translation synergistically extends survival in MYC-driven lymphoma|
JR Devlin, KM Hannan, N Hein, C Cullinane, E Kusnadi, PY Ng, ...
Cancer discovery 6 (1), 59-70, 2016