Seuraa
Lars Johannesen
Lars Johannesen
PhD student and Research fellow at FDA and Karolinska Institutet
Vahvistettu sähköpostiosoite verkkotunnuksessa halloffame.dk
Nimike
Viittaukset
Viittaukset
Vuosi
An evaluation of 30 clinical drugs against the comprehensive in vitro proarrhythmia assay (CiPA) proposed ion channel panel
WJ Crumb Jr, J Vicente, L Johannesen, DG Strauss
Journal of pharmacological and toxicological methods 81, 251-262, 2016
2572016
Comprehensive translational assessment of human-induced pluripotent stem cell derived cardiomyocytes for evaluating drug-induced arrhythmias
K Blinova, J Stohlman, J Vicente, D Chan, L Johannesen, ...
Toxicological Sciences 155 (1), 234-247, 2017
2412017
Differentiating Drug‐Induced Multichannel Block on the Electrocardiogram: Randomized Study of Dofetilide, Quinidine, Ranolazine, and Verapamil
L Johannesen, J Vicente, JW Mason, C Sanabria, K Waite‐Labott, ...
Clinical Pharmacology & Therapeutics 96 (5), 549-558, 2014
2352014
Results From the IQ‐CSRC Prospective Study Support Replacement of the Thorough QT Study by QT Assessment in the Early Clinical Phase
B Darpo, C Benson, C Dota, G Ferber, C Garnett, CL Green, V Jarugula, ...
Clinical Pharmacology & Therapeutics 97 (4), 326-335, 2015
1662015
Late sodium current block for drug‐induced long QT syndrome: Results from a prospective clinical trial
L Johannesen, J Vicente, JW Mason, C Erato, C Sanabria, K Waite‐Labott, ...
Clinical Pharmacology & Therapeutics 99 (2), 214-223, 2016
1342016
Comprehensive T wave Morphology Assessment in a Randomized Clinical Study of Dofetilide, Quinidine, Ranolazine, and Verapamil
J Vicente, L Johannesen, JW Mason, WJ Crumb, E Pueyo, N Stockbridge, ...
Journal of the American Heart Association 4 (4), e001615, 2015
1342015
Mechanistic Model‐Informed Proarrhythmic Risk Assessment of Drugs: Review of the “CiPA” Initiative and Design of a Prospective Clinical Validation Study
J Vicente, R Zusterzeel, L Johannesen, J Mason, P Sager, V Patel, ...
Clinical Pharmacology & Therapeutics 103 (1), 54-66, 2018
1182018
Common Genetic Variant Risk Score Is Associated With Drug-Induced QT Prolongation and Torsade de Pointes Risk
DG Strauss, J Vicente, L Johannesen, K Blinova, JW Mason, P Weeke, ...
Circulation 135 (14), 1300-1310, 2017
1132017
The IQ‐CSRC Prospective Clinical Phase 1 Study:“Can Early QT Assessment Using Exposure Response Analysis Replace the Thorough QT Study?”
B Darpo, N Sarapa, C Garnett, C Benson, C Dota, G Ferber, V Jarugula, ...
Annals of Noninvasive Electrocardiology 19 (1), 70-81, 2014
1102014
Improving the assessment of heart toxicity for all new drugs through translational regulatory science
L Johannesen, J Vicente, RA Gray, L Galeotti, Z Loring, CE Garnett, ...
Clinical Pharmacology & Therapeutics 95 (5), 501-508, 2014
932014
Mechanisms of sex and age differences in ventricular repolarization in humans
J Vicente, L Johannesen, L Galeotti, DG Strauss
American heart journal 168 (5), 749-756. e3, 2014
852014
Automatic ECG quality scoring methodology: mimicking human annotators
L Johannesen, L Galeotti
Physiological Measurement 33 (9), 1479, 2012
722012
Assessment of Multi‐Ion Channel Block in a Phase I Randomized Study Design: Results of the Ci PA Phase I ECG Biomarker Validation Study
J Vicente, R Zusterzeel, L Johannesen, R Ochoa‐Jimenez, JW Mason, ...
Clinical Pharmacology & Therapeutics 105 (4), 943-953, 2019
692019
A Comparison of IIR and Wavelet Filtering for Noise Reduction of the ECG
JS Sørensen, L Johannesen, USL Grove, K Lundhus, JP Couderc, C Graff
Computing in Cardiology, 2010, 489-492, 2010
542010
Assessment of ECG quality on an android platform
L Johannesen
Computing in Cardiology 38, 433-436, 2011
442011
Electrocardiographic Biomarkers for Detection of Drug-Induced Late Sodium Current Block
J Vicente, L Johannesen, M Hosseini, JW Mason, PT Sager, E Pueyo, ...
PLOS ONE 11 (12), e0163619, 2016
432016
Automated Algorithm for J-Tpeak and Tpeak-Tend Assessment of Drug-Induced Proarrhythmia Risk
L Johannesen, J Vicente, M Hosseini, DG Strauss
PLOS ONE 11 (12), e0166925, 2016
412016
Universal correction for QT/RR hysteresis
M Malik, L Johannesen, K Hnatkova, N Stockbridge
Drug safety 39 (6), 577-588, 2016
332016
Assessing ECG signal quality indices to discriminate ECGs with artefacts from pathologically different arrhythmic ECGs
C Daluwatte, L Johannesen, L Galeotti, J Vicente, DG Strauss, CG Scully
Physiological Measurement 37 (8), 1370, 2016
322016
Heart rate dependency of JT interval sections
K Hnatkova, L Johannesen, J Vicente, M Malik
Journal of electrocardiology 50 (6), 814-824, 2017
282017
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Artikkelit 1–20