Eirik A. Moreb
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In vivo genome editing improves muscle function in a mouse model of Duchenne muscular dystrophy
CE Nelson, CH Hakim, DG Ousterout, PI Thakore, EA Moreb, RMC Rivera, ...
Science 351 (6271), 403-407, 2016
Large-scale bioprocess competitiveness: the potential of dynamic metabolic control in two-stage fermentations
JM Burg, CB Cooper, Z Ye, BR Reed, EA Moreb, MD Lynch
Current Opinion in Chemical Engineering 14, 121-136, 2016
Managing the SOS Response for Enhanced CRISPR-Cas-Based Recombineering in E. coli through Transient Inhibition of Host RecA Activity
EA Moreb, B Hoover, A Yaseen, N Valyasevi, Z Roecker, ...
ACS Synthetic Biology 6 (12), 2209-2218, 2017
Scalable, two‐stage, autoinduction of recombinant protein expression in E. coli utilizing phosphate depletion
R Menacho‐Melgar, Z Ye, EA Moreb, T Yang, JP Efromson, JS Decker, ...
Biotechnology and Bioengineering, 2020
Genome dependent Cas9/gRNA search time underlies sequence dependent gRNA activity
EA Moreb, MD Lynch
Nature Communications 12 (1), 5034, 2021
Dynamic control over feedback regulatory mechanisms improves NADPH flux and xylitol biosynthesis in engineered E. coli
S Li, Z Ye, EA Moreb, JN Hennigan, DB Castellanos, T Yang, MD Lynch
Metabolic Engineering 64, 26-40, 2021
Improved two‐stage protein expression and purification via autoinduction of both autolysis and auto DNA/RNA hydrolysis conferred by phage lysozyme and DNA/RNA endonuclease
R Menacho‐Melgar, EA Moreb, JP Efromson, T Yang, JN Hennigan, ...
Biotechnology and bioengineering 117 (9), 2852-2860, 2020
Media Robustness and Scalability of Phosphate Regulated Promoters Useful for Two-Stage Autoinduction in E. coli
EA Moreb, Z Ye, JP Efromson, JN Hennigan, R Menacho-Melgar, ...
ACS Synthetic Biology 9 (6), 1483-1486, 2020
Two-stage dynamic deregulation of metabolism improves process robustness & scalability in engineered E. coli.
Z Ye, S Li, JN Hennigan, J Lebeau, EA Moreb, J Wolf, MD Lynch
Metabolic Engineering 68, 106-118, 2021
CRISPR-Cas “non-target” sites inhibit on-target cutting rates
EA Moreb, M Hutmacher, MD Lynch
The CRISPR Journal 3 (6), 550-561, 2020
Escherichia coli Cas1/2 Endonuclease Complex Modifies Self-Targeting CRISPR/Cascade Spacers Reducing Silencing Guide Stability
Z Ye, EA Moreb, S Li, J Lebeau, R Menacho-Melgar, M Munson, ...
ACS Synthetic Biology 10 (1), 29-37, 2020
A meta-analysis of gRNA library screens enables an improved understanding of the impact of gRNA folding and structural stability on CRISPR-Cas9 activity
EA Moreb, MD Lynch
The CRISPR Journal 5 (1), 146-154, 2022
Dynamic control over feedback regulation identifies pyruvate-ferredoxin oxidoreductase as a central metabolic enzyme in stationary phase E. coli
S Li, Z Ye, J Lebeau, EA Moreb, MD Lynch
bioRxiv, 2020.07. 26.219949, 2020
Dynamic control over feedback regulation improves stationary phase fluxes in engineered E. coli.
S Li, Z Ye, J Lebeau, EA Moreb, MD Lynch
bioRxiv [Preprint], 2020
An analysis of gRNA sequence dependent cleavage highlights the importance of genomic context on CRISPR-Cas activity
EA Moreb, MD Lynch
BioRxiv, 2021.05. 06.442929, 2021
The E. coli Cas1/2 endonuclease complex reduces CRISPR/Cascade guide array stability
Z Ye, J Lebeau, EA Moreb, R Menacho-Melgar, MD Lynch
bioRxiv, 2020.07. 27.223214, 2020
397. Correction of the Dystrophin Gene By the CRISPR/Cas9 System in a Mouse Model of Muscular Dystrophy
CE Nelson, DG Ousterout, JN Robinson-Hamm, EA Moreb, ...
Molecular Therapy 23, S157-S158, 2015
2-Stage microfermentations
S Li, Z Ye, EA Moreb, R Menacho-Melgar, M Golovsky, MD Lynch
Metabolic Engineering Communications 18, e00233, 2024
Compositions and methods for auto-inducible cellular lysis and nucleotide hydrolysis
MD Lynch, RM Melgar, EA Moreb, JP Efromson
US Patent App. 17/758,477, 2023
Composistions and methods for crispr enabled dna synthesis
MD Lynch, EA Moreb, T Yang
US Patent App. 17/758,480, 2023
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