Expanding medicinal chemistry into 3D space: Metallofragments as 3D scaffolds for fragment-based drug discovery CN Morrison, KE Prosser, RW Stokes, A Cordes, N Metzler-Nolte, ... Chemical science 11 (5), 1216-1225, 2020 | 123 | 2020 |
Anticancer copper pyridine benzimidazole complexes: ROS generation, biomolecule interactions, and cytotoxicity KE Prosser, SW Chang, F Saraci, PH Le, CJ Walsby Journal of inorganic biochemistry 167, 89-99, 2017 | 107 | 2017 |
CF3 Derivatives of the Anticancer Ru(III) Complexes KP1019, NKP-1339, and Their Imidazole and Pyridine Analogues Show Enhanced Lipophilicity, Albumin … SW Chang, AR Lewis, KE Prosser, JR Thompson, M Gladkikh, MB Bally, ... Inorganic chemistry 55 (10), 4850-4863, 2016 | 72 | 2016 |
Lowering water oxidation overpotentials using the ionisable imidazole of copper (2-(2′-pyridyl) imidazole) LA Stott, KE Prosser, EK Berdichevsky, CJ Walsby, JJ Warren Chemical communications 53 (3), 651-654, 2017 | 66 | 2017 |
Activation by oxidation: Ferrocene-functionalized Ru (II)-arene complexes with anticancer, antibacterial, and antioxidant properties C Mu, KE Prosser, S Harrypersad, GA MacNeil, R Panchmatia, ... Inorganic Chemistry 57 (24), 15247-15261, 2018 | 60 | 2018 |
A catalytic antioxidant for limiting amyloid-beta peptide aggregation and reactive oxygen species generation LMF Gomes, A Mahammed, KE Prosser, JR Smith, MA Silverman, ... Chemical science 10 (6), 1634-1643, 2019 | 49 | 2019 |
Evaluation of 3-dimensionality in approved and experimental drug space KE Prosser, RW Stokes, SM Cohen ACS medicinal chemistry letters 11 (6), 1292-1298, 2020 | 46 | 2020 |
Induction of cytotoxicity in pyridine analogues of the anti-metastatic Ru (III) complex NAMI-A by ferrocene functionalization C Mu, SW Chang, KE Prosser, AWY Leung, S Santacruz, T Jang, ... Inorganic chemistry 55 (1), 177-190, 2016 | 41 | 2016 |
Electronic Structure Description of a Doubly Oxidized Bimetallic Cobalt Complex with Proradical Ligands RM Clarke, K Hazin, JR Thompson, D Savard, KE Prosser, T Storr Inorganic Chemistry 55 (2), 762-774, 2016 | 35 | 2016 |
Electron paramagnetic resonance as a tool for studying the mechanisms of paramagnetic anticancer metallodrugs KE Prosser, CJ Walsby European Journal of Inorganic Chemistry 2017 (12), 1573-1585, 2017 | 29 | 2017 |
Room temperature aqueous synthesis of UiO-66 derivatives via postsynthetic exchange M Kalaj, KE Prosser, SM Cohen Dalton Transactions 49 (26), 8841-8845, 2020 | 23 | 2020 |
Copper (II) pyridyl Aminophenolates: Hypoxia‐Selective, Nucleus‐Targeting Cytotoxins, and magnetic resonance probes KE Prosser, D Xie, A Chu, GA MacNeil, BR Varju, RT Kadakia, EL Que, ... Chemistry–A European Journal 27 (38), 9839-9849, 2021 | 11 | 2021 |
A stable open-shell redox active ditopic ligand NM Bonanno, AJ Lough, KE Prosser, CJ Walsby, PK Poddutoori, ... Dalton Transactions 45 (13), 5460-5463, 2016 | 11 | 2016 |
Electronic Structure Evaluation of an Oxidized Tris (methoxy)‐Substituted Ni Salen Complex L Chiang, RM Clarke, K Herasymchuk, M Sutherland, KE Prosser, ... European Journal of Inorganic Chemistry 2016 (1), 49-55, 2016 | 11 | 2016 |
19 F-Tagged metal binding pharmacophores for NMR screening of metalloenzymes KE Prosser, AJ Kohlbrand, H Seo, M Kalaj, SM Cohen Chemical Communications 57 (40), 4934-4937, 2021 | 8 | 2021 |
Transition Metal Ions Promote the Bioavailability of Hydrophobic Therapeutics: Cu and Zn Interactions with RNA Polymerase I Inhibitor CX5461 KE Prosser, AWY Leung, S Harrypersad, AR Lewis, MB Bally, CJ Walsby Chemistry–A European Journal 24 (24), 6334-6338, 2018 | 7 | 2018 |
A novel formulation of CX-5461, a small-molecule inhibitor of rRNA synthesis, and its use for treatment of acute myeloid leukemia models AWY Leung, M Anantha, KE Prosser, M Wehbe, CJ Walsby, MB Bally Cancer Research 76 (14_Supplement), 1319-1319, 2016 | 6 | 2016 |
Combining a Ru (II)-arene complex with a NO-releasing nitrate-ester ligand generates cytotoxic activity J Zhao, KE Prosser, SW Chang, SP Zakharia, CJ Walsby Dalton Transactions 45 (45), 18079-18083, 2016 | 6 | 2016 |
Metal complexed therapeutic agents and lipid-based nanoparticulate formulations thereof M Bally, A Leung, K Prosser, C Walsby, M Wehbe, M Anantha US Patent App. 16/061,248, 2018 | 4 | 2018 |
Optimal electrostatic interactions between substrate and protein are essential for radical chemistry in ornithine 4, 5-aminomutase C Makins, DA Whitelaw, M McGregor, A Petit, RG Mothersole, KE Prosser, ... Biochimica et Biophysica Acta (BBA)-Proteins and Proteomics 1865 (8), 1077-1084, 2017 | 4 | 2017 |