| The glut athione S-transferase supergene family: regulation of GST and the contribution of the lsoenzymes to cancer chemoprotection and drug resistance part I JD Hayes, DJ Pulford Critical reviews in biochemistry and molecular biology 30 (6), 445-520, 1995 | 4628 | 1995 |
| Glutathione transferases JD Hayes, JU Flanagan, IR Jowsey Annu. Rev. Pharmacol. Toxicol. 45, 51-88, 2005 | 4587 | 2005 |
| Glutathione and glutathione-dependent enzymes represent a co-ordinately regulated defence against oxidative stress JD Hayes, LI McLellan Free radical research 31 (4), 273-300, 1999 | 1977 | 1999 |
| The Nrf2 regulatory network provides an interface between redox and intermediary metabolism JD Hayes, AT Dinkova-Kostova Trends in biochemical sciences 39 (4), 199-218, 2014 | 1784 | 2014 |
| p62/SQSTM1 is a target gene for transcription factor NRF2 and creates a positive feedback loop by inducing antioxidant response element-driven gene transcription A Jain, T Lamark, E Sjøttem, KB Larsen, JA Awuh, A Øvervatn, ... Journal of biological chemistry 285 (29), 22576-22591, 2010 | 1338 | 2010 |
| Glutathione S-transferase polymorphisms and their biological consequences JD Hayes, RC Strange Pharmacology 61 (3), 154-166, 2000 | 1230 | 2000 |
| Keap1-dependent proteasomal degradation of transcription factor Nrf2 contributes to the negative regulation of antioxidant response element-driven gene expression M McMahon, K Itoh, M Yamamoto, JD Hayes Journal of Biological Chemistry 278 (24), 21592-21600, 2003 | 1208 | 2003 |
| Oxidative stress in cancer JD Hayes, AT Dinkova-Kostova, KD Tew Cancer cell 38 (2), 167-197, 2020 | 1128 | 2020 |
| NRF2 and KEAP1 mutations: permanent activation of an adaptive response in cancer JD Hayes, M McMahon Trends in biochemical sciences 34 (4), 176-188, 2009 | 968 | 2009 |
| Nomenclature for human glutathione transferases. B Mannervik, YC Awasthi, PG Board, JD Hayes, C Di Ilio, B Ketterer, ... Biochemical Journal 282 (Pt 1), 305, 1992 | 897 | 1992 |
| Therapeutic targeting of the NRF2 and KEAP1 partnership in chronic diseases A Cuadrado, AI Rojo, G Wells, JD Hayes, SP Cousin, WL Rumsey, ... Nature reviews Drug discovery 18 (4), 295-317, 2019 | 839 | 2019 |
| The Cap ‘n’Collar basic leucine zipper transcription factor Nrf2 (NF-E2 p45-related factor 2) controls both constitutive and inducible expression of intestinal detoxification … M McMahon, K Itoh, M Yamamoto, SA Chanas, CJ Henderson, ... Cancer research 61 (8), 3299-3307, 2001 | 795 | 2001 |
| Mechanisms of activation of the transcription factor Nrf2 by redox stressors, nutrient cues, and energy status and the pathways through which it attenuates degenerative disease LE Tebay, H Robertson, ST Durant, SR Vitale, TM Penning, ... Free Radical Biology and Medicine 88, 108-146, 2015 | 745 | 2015 |
| SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner P Rada, AI Rojo, S Chowdhry, M McMahon, JD Hayes, A Cuadrado Molecular and cellular biology 31 (6), 1121-1133, 2011 | 737 | 2011 |
| Dietary indoles and isothiocyanates that are generated from cruciferous vegetables can both stimulate apoptosis and confer protection against DNA damage in human colon cell lines C Bonnesen, IM Eggleston, JD Hayes Cancer research 61 (16), 6120-6130, 2001 | 643 | 2001 |
| Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity S Chowdhry, Y Zhang, M McMahon, C Sutherland, A Cuadrado, ... Oncogene 32 (32), 3765-3781, 2013 | 597 | 2013 |
| Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway JD Hayes, M McMahon, S Chowdhry, AT Dinkova-Kostova Antioxidants & redox signaling 13 (11), 1713-1748, 2010 | 592 | 2010 |
| Identification of a novel Nrf2-regulated antioxidant response element (ARE) in the mouse NAD (P) H: quinone oxidoreductase 1 gene: reassessment of the ARE consensus sequence P Nioi, M McMahon, K Itoh, M Yamamoto, JD Hayes Biochemical Journal 374 (2), 337-348, 2003 | 556 | 2003 |
| Dimerization of substrate adaptors can facilitate cullin-mediated ubiquitylation of proteins by a “tethering” mechanism: a two-site interaction model for the Nrf2-Keap1 complex M McMahon, N Thomas, K Itoh, M Yamamoto, JD Hayes Journal of Biological Chemistry 281 (34), 24756-24768, 2006 | 532 | 2006 |
| Loss of the Nrf2 transcription factor causes a marked reduction in constitutive and inducible expression of the glutathione S-transferase Gsta1, Gsta2, Gstm1, Gstm2, Gstm3 and … SA Chanas, Q Jiang, M McMahon, GK McWalter, LI McLellan, ... Biochemical Journal 365 (2), 405-416, 2002 | 503 | 2002 |
Albena T. Dinkova-KostovaProfessor of Chemical Biology, University of DundeeVerified email at dundee.ac.uk
