Robert G. Thorne
Robert G. Thorne
Denali Fellow, Denali Therapeutics
Vahvistettu sähköpostiosoite verkkotunnuksessa dnli.com - Kotisivu
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Delivery of insulin-like growth factor-I to the rat brain and spinal cord along olfactory and trigeminal pathways following intranasal administration
RG Thorne, GJ Pronk, V Padmanabhan, WH Frey Ii
Neuroscience 127 (2), 481-496, 2004
8302004
Intranasal delivery of biologics to the central nervous system
JJ Lochhead, RG Thorne
Advanced drug delivery reviews 64 (7), 614-628, 2012
6822012
In vivo diffusion analysis with quantum dots and dextrans predicts the width of brain extracellular space
RG Thorne, C Nicholson
Proceedings of the National Academy of Sciences 103 (14), 5567-5572, 2006
5222006
Delivery of neurotrophic factors to the central nervous system
RG Thorne, WH Frey
Clinical pharmacokinetics 40 (12), 907-946, 2001
4882001
Quantitative analysis of the olfactory pathway for drug delivery to the brain
RG Thorne, CR Emory, TA Ala, WH Frey II
Brain research 692 (1-2), 278-282, 1995
3671995
Intranasal administration of insulin-like growth factor-I bypasses the blood–brain barrier and protects against focal cerebral ischemic damage
XF Liu, JR Fawcett, RG Thorne, TA DeFor, WH Frey II
Journal of the neurological sciences 187 (1-2), 91-97, 2001
2642001
Intranasal administration of interferon beta bypasses the blood–brain barrier to target the central nervous system and cervical lymph nodes: a non-invasive treatment strategy …
TM Ross, PM Martinez, JC Renner, RG Thorne, LR Hanson, WH Frey Ii
Journal of neuroimmunology 151 (1-2), 66-77, 2004
2442004
Delivery of 125I-NGF to the brain via the olfactory route
WH Frey, J Liu, X Chen, RG Thorne, JR Fawcett, TA Ala, YE Rahman
Drug Delivery 4 (2), 87-92, 1997
2221997
The role of brain barriers in fluid movement in the CNS: is there a ‘glymphatic’system?
NJ Abbott, ME Pizzo, JE Preston, D Janigro, RG Thorne
Acta neuropathologica 135 (3), 387-407, 2018
2062018
Delivery of interferon-β to the monkey nervous system following intranasal administration
RG Thorne, LR Hanson, TM Ross, D Tung, WH Frey Ii
Neuroscience 152 (3), 785-797, 2008
2062008
Diffusion of macromolecules in the brain: implications for drug delivery
DJ Wolak, RG Thorne
Molecular pharmaceutics 10 (5), 1492-1504, 2013
1942013
Diffusion of epidermal growth factor in rat brain extracellular space measured by integrative optical imaging
RG Thorne, S Hrabetová, C Nicholson
Journal of neurophysiology 92 (6), 3471-3481, 2004
1832004
Non-invasive intranasal insulin-like growth factor-I reduces infarct volume and improves neurologic function in rats following middle cerebral artery occlusion
XF Liu, JR Fawcett, RG Thorne, WH Frey Ii
Neuroscience letters 308 (2), 91-94, 2001
1762001
Rapid transport within cerebral perivascular spaces underlies widespread tracer distribution in the brain after intranasal administration
JJ Lochhead, DJ Wolak, ME Pizzo, RG Thorne
Journal of Cerebral Blood Flow & Metabolism 35 (3), 371-381, 2015
1482015
In vivo diffusion of lactoferrin in brain extracellular space is regulated by interactions with heparan sulfate
RG Thorne, A Lakkaraju, E Rodriguez-Boulan, C Nicholson
Proceedings of the National Academy of Sciences 105 (24), 8416-8421, 2008
1152008
Cavitation mixer
R Schueler
US Patent 6,935,770, 2005
942005
Intrathecal antibody distribution in the rat brain: surface diffusion, perivascular transport and osmotic enhancement of delivery
ME Pizzo, DJ Wolak, NN Kumar, E Brunette, CL Brunnquell, MJ Hannocks, ...
The Journal of physiology 596 (3), 445-475, 2018
932018
Method for administering agents to the central nervous system
IIWH Frey, RG Thorne
US Patent 7,273,618, 2007
642007
Molecular characterization of perivascular drainage pathways in the murine brain
MJ Hannocks, ME Pizzo, J Huppert, T Deshpande, NJ Abbott, RG Thorne, ...
Journal of Cerebral Blood Flow & Metabolism 38 (4), 669-686, 2018
612018
Probing the extracellular diffusion of antibodies in brain using in vivo integrative optical imaging and ex vivo fluorescence imaging
DJ Wolak, ME Pizzo, RG Thorne
Journal of Controlled Release 197, 78-86, 2015
462015
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