| Asymmetric dimethylarginine causes hypertension and cardiac dysfunction in humans and is actively metabolized by dimethylarginine dimethylaminohydrolase V Achan, M Broadhead, M Malaki, G Whitley, J Leiper, R MacAllister, ... Arteriosclerosis, thrombosis, and vascular biology 23 (8), 1455-1459, 2003 | 830 | 2003 |
| Cardiovascular biology of the asymmetric dimethylarginine: dimethylarginine dimethylaminohydrolase pathway P Vallance, J Leiper Arteriosclerosis, thrombosis, and vascular biology 24 (6), 1023-1030, 2004 | 798 | 2004 |
| Identification of two human dimethylarginine dimethylaminohydrolases with distinct tissue distributions and homology with microbial arginine deiminases JM LEIPER, JS MARIA, A CHUBB, RJ MACALLISTER, IG CHARLES, ... Biochemical Journal 343 (1), 209-214, 1999 | 664 | 1999 |
| Biological significance of endogenous methylarginines that inhibit nitric oxide synthases J Leiper, P Vallance Cardiovascular research 43 (3), 542-548, 1999 | 596 | 1999 |
| Disruption of methylarginine metabolism impairs vascular homeostasis J Leiper, M Nandi, B Torondel, J Murray-Rust, M Malaki, B O'Hara, ... Nature medicine 13 (2), 198-203, 2007 | 478 | 2007 |
| The ddah/adma/nos pathway CTL Tran, JM Leiper, P Vallance Atherosclerosis Supplements 4 (4), 33-40, 2003 | 469 | 2003 |
| Blocking NO synthesis: how, where and why? P Vallance, J Leiper Nature Reviews Drug Discovery 1 (12), 939-950, 2002 | 420 | 2002 |
| S-nitrosylation of dimethylarginine dimethylaminohydrolase regulates enzyme activity: Further interactions between nitric oxide synthase and dimethylarginine … J Leiper, J Murray-Rust, N McDonald, P Vallance Proceedings of the National Academy of Sciences 99 (21), 13527-13532, 2002 | 397 | 2002 |
| Structural insights into the hydrolysis of cellular nitric oxide synthase inhibitors by dimethylarginine dimethylaminohydrolase J Murray-Rust, J Leiper, M McAlister, J Phelan, S Tilley, JS Maria, ... Nature structural biology 8 (8), 679-683, 2001 | 319 | 2001 |
| Unexpected effect of proton pump inhibitors: elevation of the cardiovascular risk factor asymmetric dimethylarginine YT Ghebremariam, P LePendu, JC Lee, DA Erlanson, A Slaviero, ... Circulation 128 (8), 845-853, 2013 | 274 | 2013 |
| Chromosomal Localization, Gene Structure, and Expression Pattern of DDAH1: Comparison with DDAH2 and Implications for Evolutionary Origins CTL Tran, MF Fox, P Vallance, JM Leiper Genomics 68 (1), 101-105, 2000 | 267 | 2000 |
| Microsomal triglyceride transfer protein, the abetalipoproteinemia gene product, mediates the secretion of apolipoprotein B-containing lipoproteins from heterologous cells. JM Leiper, JD Bayliss, RJ Pease, DJ Brett, J Scott, CC Shoulders Journal of Biological Chemistry 269 (35), 21951-21954, 1994 | 193 | 1994 |
| Isoform-Specific Regulation by NG,NG-Dimethylarginine Dimethylaminohydrolase of Rat Serum Asymmetric Dimethylarginine and Vascular Endothelium … D Wang, PS Gill, T Chabrashvili, ML Onozato, J Raggio, M Mendonca, ... Circulation Research 101 (6), 627-635, 2007 | 191 | 2007 |
| The therapeutic potential of targeting endogenous inhibitors of nitric oxide synthesis J Leiper, M Nandi Nature Reviews Drug Discovery 10 (4), 277-291, 2011 | 189 | 2011 |
| all-trans-Retinoic Acid Increases Nitric Oxide Synthesis by Endothelial Cells: A Role for the Induction of Dimethylarginine Dimethylaminohydrolase V Achan, CTL Tran, F Arrigoni, GSJ Whitley, JM Leiper, P Vallance Circulation research 90 (7), 764-769, 2002 | 183 | 2002 |
| Evidence for dysregulation of dimethylarginine dimethylaminohydrolase I in chronic hypoxia–induced pulmonary hypertension LJ Millatt, GSJ Whitley, D Li, JM Leiper, HM Siragy, RM Carey, RA Johns Circulation 108 (12), 1493-1498, 2003 | 178 | 2003 |
| Metabolism of asymmetric dimethylarginines is regulated in the lung developmentally and with pulmonary hypertension induced by hypobaric hypoxia FI Arrigoni, P Vallance, SG Haworth, JM Leiper Circulation 107 (8), 1195-1201, 2003 | 173 | 2003 |
| Analysis of methylarginine metabolism in the cardiovascular system identifies the lung as a major source of ADMA P Bulau, D Zakrzewicz, K Kitowska, J Leiper, A Gunther, F Grimminger, ... American Journal of Physiology-Lung Cellular and Molecular Physiology 292 (1 …, 2007 | 160 | 2007 |
| Epigenetic and neurological effects and safety of high-dose nicotinamide in patients with Friedreich's ataxia: an exploratory, open-label, dose-escalation study V Libri, C Yandim, S Athanasopoulos, N Loyse, T Natisvili, PP Law, ... The Lancet 384 (9942), 504-513, 2014 | 156 | 2014 |
| Increasing dimethylarginine levels are associated with adverse clinical outcome in severe alcoholic hepatitis RP Mookerjee, M Malaki, NA Davies, SJ Hodges, RN Dalton, C Turner, ... Hepatology 45 (1), 62-71, 2007 | 142 | 2007 |
Beata Wojciak-Stothardlecturer in Vascular Biology, Imperial College LondonVerified email at imperial.ac.uk
