Paul Meakin
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ...
Nature 556 (7699), 113-117, 2018
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
S Chowdhry, MH Nazmy, PJ Meakin, AT Dinkova-Kostova, SV Walsh, ...
Free Radical Biology and Medicine 48 (2), 357-371, 2010
Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein …
PJ Meakin, S Chowdhry, RS Sharma, FB Ashford, SV Walsh, ...
Molecular and cellular biology 34 (17), 3305-3320, 2014
Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2
KFS Bell, B Al-Mubarak, MA Martel, S McKay, N Wheelan, P Hasel, ...
Nature communications 6 (1), 7066, 2015
The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis
L Deldicque, PD Cani, A Philp, JM Raymackers, PJ Meakin, MLJ Ashford, ...
American Journal of Physiology-Endocrinology and Metabolism 299 (5), E695-E705, 2010
Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice
PJ Meakin, AJ Harper, DL Hamilton, J Gallagher, AD McNeilly, ...
Biochemical Journal 441 (1), 285-296, 2012
Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation
VA McGuire, T Ruiz-Zorrilla Diez, CH Emmerich, S Strickson, MS Ritorto, ...
Scientific reports 6 (1), 31159, 2016
Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated …
J Rzepecka, MA Pineda, L Al-Riyami, DT Rodgers, JK Huggan, FE Lumb, ...
Journal of autoimmunity 60, 59-73, 2015
Phosphoinositide 3-Kinases Upregulate System xc via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in …
J Lewerenz, P Baxter, R Kassubek, P Albrecht, J Van Liefferinge, ...
Antioxidants & redox signaling 20 (18), 2907-2922, 2014
The beta secretase BACE1 regulates the expression of insulin receptor in the liver
PJ Meakin, A Mezzapesa, E Benabou, ME Haas, B Bonardo, M Grino, ...
Nature communications 9 (1), 1306, 2018
Small vessels, dementia and chronic diseases–molecular mechanisms and pathophysiology
K Horsburgh, JM Wardlaw, T Van Agtmael, SM Allan, MLJ Ashford, ...
Clinical science 132 (8), 851-868, 2018
Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression
KR Watterson, D Bestow, J Gallagher, DL Hamilton, FB Ashford, ...
Neurosignals 21 (1-2), 28-41, 2013
Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction
PJ Meakin, BM Coull, Z Tuharska, C McCaffery, I Akoumianakis, ...
The Journal of Clinical Investigation 130 (8), 4104-4117, 2020
Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice
PJ Meakin, SM Jalicy, G Montagut, DJP Allsop, DL Cavellini, SW Irvine, ...
Scientific reports 8 (1), 55, 2018
The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling
G Botteri, L Salvadó, A Gumŕ, DL Hamilton, PJ Meakin, G Montagut, ...
Metabolism 85, 59-75, 2018
Fructose supports energy metabolism of some, but not all, axons in adult mouse optic nerve
L Allen, S Anderson, R Wender, P Meakin, BR Ransom, DE Ray, ...
Journal of neurophysiology 95 (3), 1917-1925, 2006
BACE1: More than just a β‐secretase
HA Taylor, L Przemylska, EM Clavane, PJ Meakin
Obesity Reviews 23 (7), e13430, 2022
Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes
RF Deighton, NM Márkus, B Al-Mubarak, KFS Bell, S Papadia, PJ Meakin, ...
Proceedings of the National Academy of Sciences 111 (18), E1818-E1820, 2014
Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes
DL Hamilton, JA Findlay, G Montagut, PJ Meakin, D Bestow, SM Jalicy, ...
Diabetologia 57, 1684-1692, 2014
Fructose metabolism in the adult mouse optic nerve, a central white matter tract
PJ Meakin, MJ Fowler, AJ Rathbone, LM Allen, BR Ransom, DE Ray, ...
Journal of Cerebral Blood Flow & Metabolism 27 (1), 86-99, 2007
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