| Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1 EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ... Nature 556 (7699), 113-117, 2018 | 1151 | 2018 |
| Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis S Chowdhry, MH Nazmy, PJ Meakin, AT Dinkova-Kostova, SV Walsh, ... Free Radical Biology and Medicine 48 (2), 357-371, 2010 | 292 | 2010 |
| Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein … PJ Meakin, S Chowdhry, RS Sharma, FB Ashford, SV Walsh, ... Molecular and cellular biology 34 (17), 3305-3320, 2014 | 222 | 2014 |
| Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2 KFS Bell, B Al-Mubarak, MA Martel, S McKay, N Wheelan, P Hasel, ... Nature communications 6 (1), 7066, 2015 | 175 | 2015 |
| The unfolded protein response is activated in skeletal muscle by high-fat feeding: potential role in the downregulation of protein synthesis L Deldicque, PD Cani, A Philp, JM Raymackers, PJ Meakin, MLJ Ashford, ... American Journal of Physiology-Endocrinology and Metabolism 299 (5), E695-E705, 2010 | 169 | 2010 |
| Reduction in BACE1 decreases body weight, protects against diet-induced obesity and enhances insulin sensitivity in mice PJ Meakin, AJ Harper, DL Hamilton, J Gallagher, AD McNeilly, ... Biochemical Journal 441 (1), 285-296, 2012 | 145 | 2012 |
| Dimethyl fumarate blocks pro-inflammatory cytokine production via inhibition of TLR induced M1 and K63 ubiquitin chain formation VA McGuire, T Ruiz-Zorrilla Diez, CH Emmerich, S Strickson, MS Ritorto, ... Scientific reports 6 (1), 31159, 2016 | 107 | 2016 |
| Prophylactic and therapeutic treatment with a synthetic analogue of a parasitic worm product prevents experimental arthritis and inhibits IL-1β production via NRF2-mediated … J Rzepecka, MA Pineda, L Al-Riyami, DT Rodgers, JK Huggan, FE Lumb, ... Journal of autoimmunity 60, 59-73, 2015 | 85 | 2015 |
| Phosphoinositide 3-Kinases Upregulate System xc− via Eukaryotic Initiation Factor 2α and Activating Transcription Factor 4 – A Pathway Active in … J Lewerenz, P Baxter, R Kassubek, P Albrecht, J Van Liefferinge, ... Antioxidants & redox signaling 20 (18), 2907-2922, 2014 | 75 | 2014 |
| The beta secretase BACE1 regulates the expression of insulin receptor in the liver PJ Meakin, A Mezzapesa, E Benabou, ME Haas, B Bonardo, M Grino, ... Nature communications 9 (1), 1306, 2018 | 56 | 2018 |
| Small vessels, dementia and chronic diseases–molecular mechanisms and pathophysiology K Horsburgh, JM Wardlaw, T Van Agtmael, SM Allan, MLJ Ashford, ... Clinical science 132 (8), 851-868, 2018 | 54 | 2018 |
| Anorexigenic and orexigenic hormone modulation of mammalian target of rapamycin complex 1 activity and the regulation of hypothalamic agouti-related protein mRNA expression KR Watterson, D Bestow, J Gallagher, DL Hamilton, FB Ashford, ... Neurosignals 21 (1-2), 28-41, 2013 | 47 | 2013 |
| Elevated circulating amyloid concentrations in obesity and diabetes promote vascular dysfunction PJ Meakin, BM Coull, Z Tuharska, C McCaffery, I Akoumianakis, ... The Journal of Clinical Investigation 130 (8), 4104-4117, 2020 | 38 | 2020 |
| Bace1-dependent amyloid processing regulates hypothalamic leptin sensitivity in obese mice PJ Meakin, SM Jalicy, G Montagut, DJP Allsop, DL Cavellini, SW Irvine, ... Scientific reports 8 (1), 55, 2018 | 38 | 2018 |
| The BACE1 product sAPPβ induces ER stress and inflammation and impairs insulin signaling G Botteri, L Salvadó, A Gumŕ, DL Hamilton, PJ Meakin, G Montagut, ... Metabolism 85, 59-75, 2018 | 34 | 2018 |
| Fructose supports energy metabolism of some, but not all, axons in adult mouse optic nerve L Allen, S Anderson, R Wender, P Meakin, BR Ransom, DE Ray, ... Journal of neurophysiology 95 (3), 1917-1925, 2006 | 34 | 2006 |
| BACE1: More than just a β‐secretase HA Taylor, L Przemylska, EM Clavane, PJ Meakin Obesity Reviews 23 (7), e13430, 2022 | 29 | 2022 |
| Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes RF Deighton, NM Márkus, B Al-Mubarak, KFS Bell, S Papadia, PJ Meakin, ... Proceedings of the National Academy of Sciences 111 (18), E1818-E1820, 2014 | 29 | 2014 |
| Altered amyloid precursor protein processing regulates glucose uptake and oxidation in cultured rodent myotubes DL Hamilton, JA Findlay, G Montagut, PJ Meakin, D Bestow, SM Jalicy, ... Diabetologia 57, 1684-1692, 2014 | 26 | 2014 |
| Fructose metabolism in the adult mouse optic nerve, a central white matter tract PJ Meakin, MJ Fowler, AJ Rathbone, LM Allen, BR Ransom, DE Ray, ... Journal of Cerebral Blood Flow & Metabolism 27 (1), 86-99, 2007 | 23 | 2007 |
Mike AshfordProfessor of Neuroscience, University of DundeeVerified email at dundee.ac.uk
