Mike Ashford
Mike Ashford
Professor of Neuroscience, University of Dundee
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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1
EL Mills, DG Ryan, HA Prag, D Dikovskaya, D Menon, Z Zaslona, ...
Nature 556 (7699), 113-117, 2018
Leptin inhibits hypothalamic neurons by activation of ATP-sensitive potassium channels
D Spanswick, MA Smith, VE Groppi, SD Logan, MLJ Ashford
Nature 390 (6659), 521-525, 1997
The sulphonylurea receptor may be an ATP-sensitive potassium channel
NC Sturgess, DL Cook, MLJ Ashford, CN Hales
The Lancet 326 (8453), 474-475, 1985
Insulin activates ATP-sensitive K+ channels in hypothalamic neurons of lean, but not obese rats
D Spanswick, MA Smith, S Mirshamsi, VH Routh, MLJ Ashford
Nature neuroscience 3 (8), 757-758, 2000
AMPK is essential for energy homeostasis regulation and glucose sensing by POMC and AgRP neurons
M Claret, MA Smith, RL Batterham, C Selman, AI Choudhury, LGD Fryer, ...
The Journal of clinical investigation 117 (8), 2325-2336, 2007
Glucose-induced excitation of hypothalamic neurones is mediated by ATP-sensitive K+ channels
MLJ Ashford, PR Boden, JM Treherne
Pflügers Archiv 415, 479-483, 1990
Adenosine-5′-triphosphate-sensitive ion channels in neonatal rat cultured central neurones
MLJ Ashford, NC Sturgess, NJ Trout, NJ Gardner, CN Hales
Pflügers Archiv 412, 297-304, 1988
AMPK: regulating energy balance at the cellular and whole body levels
DG Hardie, MLJ Ashford
Physiology 29 (2), 99-107, 2014
ATP-sensitive K+ channels in pancreatic β-cells: spare-channel hypothesis
DL Cook, LS Satin, MLJ Ashford, CN Hales
Diabetes 37 (5), 495-498, 1988
Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis
S Chowdhry, MH Nazmy, PJ Meakin, AT Dinkova-Kostova, SV Walsh, ...
Free Radical Biology and Medicine 48 (2), 357-371, 2010
The role of insulin receptor substrate 2 in hypothalamic and β cell function
AI Choudhury, H Heffron, MA Smith, H Al-Qassab, AW Xu, C Selman, ...
The Journal of clinical investigation 115 (4), 940-950, 2005
Cloning and functional expression of a rat heart KATP channel
MLJ Ashford, CT Bond, TA Blair, JP Adelmair
Nature 370 (6489), 456-459, 1994
Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein …
PJ Meakin, S Chowdhry, RS Sharma, FB Ashford, SV Walsh, ...
Molecular and cellular biology 34 (17), 3305-3320, 2014
Evidence for the presence of CB2-like cannabinoid receptors on peripheral nerve terminals
G Griffin, SR Fernando, RA Ross, NG McKay, MLJ Ashford, D Shire, ...
European journal of pharmacology 339 (1), 53-61, 1997
Dynamic imaging of free cytosolic ATP concentration during fuel sensing by rat hypothalamic neurones: evidence for ATP‐independent control of ATP‐sensitive K+ channels
EK Ainscow, S Mirshamsi, T Tang, MLJ Ashford, GA Rutter
The Journal of physiology 544 (2), 429-445, 2002
Effects of sulphonylureas and diazoxide on insulin secretion and nucleotide-sensitive channels in an insulin-secreting cell line.
NC Sturgess, RZ Kozlowski, CA Carrington, CN Hales, ML Ashford
British journal of pharmacology 95 (1), 83, 1988
Leptin inhibits epileptiform‐like activity in rat hippocampal neurones via PI 3‐kinase‐driven activation of BK channels
LJ Shanley, D O'malley, AJ Irving, ML Ashford, J Harvey
The Journal of physiology 545 (3), 933-944, 2002
Leptin in the CNS: much more than a satiety signal
J Harvey, MLJ Ashford
Neuropharmacology 44 (7), 845-854, 2003
Leptin and insulin stimulation of signalling pathways in arcuate nucleus neurones: PI3K dependent actin reorganization and KATPchannel activation
S Mirshamsi, HA Laidlaw, K Ning, E Anderson, LA Burgess, A Gray, ...
BMC neuroscience 5 (1), 1-18, 2004
Tolbutamide excites rat glucoreceptive ventromedial hypothalamic neurones by indirect inhibition of ATP-K+ channels.
ML Ashford, PR Boden, JM Treherne
British journal of pharmacology 101 (3), 531, 1990
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