Pekka T. Männistö
Pekka T. Männistö
professor of pharmacology and drug development (emer.)
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Catechol-O-methyltransferase (COMT): biochemistry, molecular biology, pharmacology, and clinical efficacy of the new selective COMT inhibitors
PT Männistö, S Kaakkola
Pharmacological reviews 51 (4), 593-628, 1999
Neurotransmitter regulation of anterior pituitary hormones
J Tuomisto, P Männistö
Pharmacological Reviews 37 (3), 249-332, 1985
Dopamine supersensitivity correlates with D2High states, implying many paths to psychosis
P Seeman, D Weinshenker, R Quirion, LK Srivastava, SK Bhardwaj, ...
Proceedings of the National Academy of Sciences 102 (9), 3513-3518, 2005
Pharmacologically diverse antidepressants rapidly activate brain-derived neurotrophic factor receptor TrkB and induce phospholipase-Cγ signaling pathways in mouse brain
T Rantamäki, P Hendolin, A Kankaanpää, J Mijatovic, P Piepponen, ...
Neuropsychopharmacology 32 (10), 2152-2162, 2007
Site-specific role of catechol-O-methyltransferase in dopamine overflow within prefrontal cortex and dorsal striatum
L Yavich, MM Forsberg, M Karayiorgou, JA Gogos, PT Männistö
Journal of Neuroscience 27 (38), 10196-10209, 2007
On the role of prolyl oligopeptidase in health and disease
JA García-Horsman, PT Männistö, JI Venäläinen
Neuropeptides 41 (1), 1-24, 2007
Characteristics of catechol O-methyl-transferase (COMT) and properties of selective COMT inhibitors
PT Männistö, I Ulmanen, K Lundström, J Taskinen, J Tenhunen, ...
Progress in drug research. Fortschritte der Arzneimittelforschung. Progres …, 1992
Brain catecholamine metabolism in catechol‐O‐methyltransferase (COMT)‐deficient mice
M Huotari, JA Gogos, M Karayiorgou, O Koponen, M Forsberg, ...
European Journal of Neuroscience 15 (2), 246-256, 2002
Quantitative role of COMT in dopamine clearance in the prefrontal cortex of freely moving mice
M Käenmäki, A Tammimäki, T Myöhänen, K Pakarinen, C Amberg, ...
Journal of neurochemistry 114 (6), 1745-1755, 2010
Catechol-O-methyltransferase gene polymorphism and chronic human pain: a systematic review and meta-analysis
A Tammimäki, PT Männistö
Pharmacogenetics and genomics 22 (9), 673-691, 2012
The multiple faces of quercetin in neuroprotection
B Ossola, TM Kääriäinen, PT Männistö
Expert opinion on drug safety 8 (4), 397-409, 2009
Rationale for selective COMT inhibitors as adjuncts in the drug treatment of Parkinson's disease
PT Männistö, S Kaakkola
Pharmacology & toxicology 66 (5), 317-323, 1990
Chronic infusion of CDNF prevents 6-OHDA-induced deficits in a rat model of Parkinson's disease
MH Voutilainen, S Bäck, J Peränen, P Lindholm, A Raasmaja, ...
Experimental neurology 228 (1), 99-108, 2011
General properties and clinical possibilities of new selective inhibitors of catechol O-methyltransferase
S Kaakkola, A Gordin, PT Männistö
General Pharmacology: The Vascular System 25 (5), 813-824, 1994
7-Nitroindazole, a nitric oxide synthase inhibitor, has anxiolytic-like properties in exploratory models of anxiety
V Volke, A Soosaar, S Ko˜ ks, M Bourin, PT Männistö, E Vasar
Psychopharmacology 131, 399-405, 1997
New selective COMT inhibitors: useful adjuncts for Parkinson's disease?
PT Männistö, S Kaakkola
Trends in pharmacological sciences 10 (2), 54-56, 1989
Prolyl oligopeptidase: a potential target for the treatment of cognitive disorders.
PT Maennisto, J Venäläinen, A Jalkanen, JA García-Horsman
Drug news & perspectives 20 (5), 293-305, 2007
Inhibition of catechol-O-methyltransferase activity by two novel disubstituted catechols in the rat
E Nissinen, IB Lindén, E Schultz, S Kaakkola, PT Männistö, P Pohto
European journal of pharmacology 153 (2-3), 263-269, 1988
Activation of 5-HT2A receptors impairs response control of rats in a five-choice serial reaction time task
T Koskinen, S Ruotsalainen, T Puumala, R Lappalainen, E Koivisto, ...
Neuropharmacology 39 (3), 471-481, 2000
A prolyl oligopeptidase inhibitor, KYP‐2047, reduces α‐synuclein protein levels and aggregates in cellular and animal models of Parkinson's disease
TT Myöhänen, MJ Hannula, R Van Elzen, M Gérard, P Van Der Veken, ...
British journal of pharmacology 166 (3), 1097-1113, 2012
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