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Jeremy L. Jenkins
Jeremy L. Jenkins
US Head Discovery Sciences, Novartis BioMedical Research
Verified email at novartis.com
Title
Cited by
Cited by
Year
Structure of the DDB1–CRBN E3 ubiquitin ligase in complex with thalidomide
ES Fischer, K Böhm, JR Lydeard, H Yang, MB Stadler, S Cavadini, ...
Nature 512 (7512), 49-53, 2014
10812014
Large-scale prediction and testing of drug activity on side-effect targets
E Lounkine, MJ Keiser, S Whitebread, D Mikhailov, J Hamon, JL Jenkins, ...
Nature, 2012
9502012
Integrating high-content screening and ligand-target prediction to identify mechanism of action
DW Young, A Bender, J Hoyt, E McWhinnie, GW Chirn, CY Tao, ...
Nature chemical biology 4 (1), 59-68, 2008
4072008
Analysis of pharmacology data and the prediction of adverse drug reactions and off‐target effects from chemical structure
A Bender, J Scheiber, M Glick, JW Davies, K Azzaoui, J Hamon, L Urban, ...
ChemMedChem: Chemistry Enabling Drug Discovery 2 (6), 861-873, 2007
3992007
From in silico target prediction to multi-target drug design: Current databases, methods and applications
A Koutsoukas, B Simms, J Kirchmair, PJ Bond, AV Whitmore, S Zimmer, ...
Journal of proteomics 74 (12), 2554-2574, 2011
3692011
How similar are similarity searching methods? A principal component analysis of molecular descriptor space
A Bender, JL Jenkins, J Scheiber, SCK Sukuru, M Glick, JW Davies
Journal of chemical information and modeling 49 (1), 108-119, 2009
3512009
Prediction of biological targets for compounds using multiple-category Bayesian models trained on chemogenomics databases
Nidhi, M Glick, JW Davies, JL Jenkins
Journal of chemical information and modeling 46 (3), 1124-1133, 2006
3372006
Phenotypic landscape of intestinal organoid regeneration
I Lukonin, D Serra, L Challet Meylan, K Volkmann, J Baaten, R Zhao, ...
Nature 586 (7828), 275-280, 2020
2412020
Bridging chemical and biological space:“target fishing” using 2D and 3D molecular descriptors
JH Nettles, JL Jenkins, A Bender, Z Deng, JW Davies, M Glick
Journal of medicinal chemistry 49 (23), 6802-6810, 2006
2352006
In silico target fishing: Predicting biological targets from chemical structure
JL Jenkins, A Bender, JW Davies
Drug Discovery Today: Technologies 3 (4), 413-421, 2006
2222006
Modeling promiscuity based on in vitro safety pharmacology profiling data
K Azzaoui, J Hamon, B Faller, S Whitebread, E Jacoby, A Bender, ...
ChemMedChem: Chemistry Enabling Drug Discovery 2 (6), 874-880, 2007
2132007
Mapping adverse drug reactions in chemical space
J Scheiber, JL Jenkins, SCK Sukuru, A Bender, D Mikhailov, M Milik, ...
Journal of medicinal chemistry 52 (9), 3103-3107, 2009
2022009
DRUG-seq for miniaturized high-throughput transcriptome profiling in drug discovery
C Ye, DJ Ho, M Neri, C Yang, T Kulkarni, R Randhawa, M Henault, ...
Nature communications 9 (1), 4307, 2018
1942018
Gaining insight into off-target mediated effects of drug candidates with a comprehensive systems chemical biology analysis
J Scheiber, B Chen, M Milik, SCK Sukuru, A Bender, D Mikhailov, ...
Journal of chemical information and modeling 49 (2), 308-317, 2009
1942009
Bivalent sequential binding model of a Bacillus thuringiensis toxin to gypsy moth aminopeptidase N receptor
JL Jenkins, MK Lee, AP Valaitis, A Curtiss, DH Dean
Journal of Biological Chemistry 275 (19), 14423-14431, 2000
1802000
Rethinking molecular similarity: comparing compounds on the basis of biological activity
PM Petrone, B Simms, F Nigsch, E Lounkine, P Kutchukian, A Cornett, ...
ACS chemical biology 7 (8), 1399-1409, 2012
1752012
Identifying compound efficacy targets in phenotypic drug discovery
M Schirle, JL Jenkins
Drug discovery today 21 (1), 82-89, 2016
1682016
A 3D similarity method for scaffold hopping from known drugs or natural ligands to new chemotypes
JL Jenkins, M Glick, JW Davies
Journal of medicinal chemistry 47 (25), 6144-6159, 2004
1622004
A small-molecule inhibitor of the ribonucleolytic activity of human angiogenin that possesses antitumor activity
RYT Kao, JL Jenkins, KA Olson, ME Key, JW Fett, R Shapiro
Proceedings of the National Academy of Sciences 99 (15), 10066-10071, 2002
1512002
Streamlining lead discovery by aligning in silico and high-throughput screening
JW Davies, M Glick, JL Jenkins
Current opinion in chemical biology 10 (4), 343-351, 2006
1462006
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