How enzymes adapt: lessons from directed evolution FH Arnold, PL Wintrode, K Miyazaki, A Gershenson Trends in biochemical sciences 26 (2), 100-106, 2001 | 549 | 2001 |
Recommendations for performing, interpreting and reporting hydrogen deuterium exchange mass spectrometry (HDX-MS) experiments GR Masson, JE Burke, NG Ahn, GS Anand, C Borchers, S Brier, ... Nature methods 16 (7), 595-602, 2019 | 529 | 2019 |
Directed evolution study of temperature adaptation in a psychrophilic enzyme K Miyazaki, PL Wintrode, RA Grayling, DN Rubingh, FH Arnold Journal of molecular biology 297 (4), 1015-1026, 2000 | 390 | 2000 |
β-Sheet core of human prion protein amyloid fibrils as determined by hydrogen/deuterium exchange X Lu, PL Wintrode, WK Surewicz Proceedings of the National Academy of Sciences 104 (5), 1510-1515, 2007 | 269 | 2007 |
Thermodynamics of ubiquitin unfolding PL Wintrode, GI Makhatadze, PL Privalov Proteins: Structure, Function, and Bioinformatics 18 (3), 246-253, 1994 | 228 | 1994 |
Temperature adaptation of enzymes: lessons from laboratory evolution PL Wintrode, FH Arnold Advances in protein chemistry 55, 161-225, 2001 | 201 | 2001 |
Cold adaptation of a mesophilic subtilisin-like protease by laboratory evolution PL Wintrode, K Miyazaki, FH Arnold Journal of Biological Chemistry 275 (41), 31635-31640, 2000 | 179 | 2000 |
Hydrogen/deuterium exchange-mass spectrometry: a powerful tool for probing protein structure, dynamics and interactions Y Tsutsui, PL Wintrode Current medicinal chemistry 14 (22), 2344-2358, 2007 | 148 | 2007 |
Protein dynamics in a family of laboratory evolved thermophilic enzymes PL Wintrode, D Zhang, N Vaidehi, FH Arnold, WA Goddard III Journal of molecular biology 327 (3), 745-757, 2003 | 121 | 2003 |
Energetics of target peptide recognition by calmodulin: a calorimetric study PL Wintrode, PL Privalov Journal of molecular biology 266 (5), 1050-1062, 1997 | 101 | 1997 |
Crystal structures of the Toll/Interleukin-1 receptor (TIR) domains from the Brucella protein TcpB and host adaptor TIRAP reveal mechanisms of molecular mimicry GA Snyder, D Deredge, A Waldhuber, T Fresquez, DZ Wilkins, PT Smith, ... Journal of Biological Chemistry 289 (2), 669-679, 2014 | 84 | 2014 |
Conformational dynamics of a neurotransmitter: sodium symporter in a lipid bilayer S Adhikary, DJ Deredge, A Nagarajan, LR Forrest, PL Wintrode, SK Singh Proceedings of the National Academy of Sciences 114 (10), E1786-E1795, 2017 | 83 | 2017 |
Folding mechanism of the metastable serpin α1-antitrypsin Y Tsutsui, R Dela Cruz, PL Wintrode Proceedings of the National Academy of Sciences 109 (12), 4467-4472, 2012 | 79 | 2012 |
Patterns of adaptation in a laboratory evolved thermophilic enzyme PL Wintrode, K Miyazaki, FH Arnold Biochimica et Biophysica Acta (BBA)-Protein Structure and Molecular …, 2001 | 77 | 2001 |
Effects of glycosylation on the stability and flexibility of a metastable protein: The human serpin α1-antitrypsin A Sarkar, PL Wintrode International journal of mass spectrometry 302 (1-3), 69-75, 2011 | 63 | 2011 |
Successes and challenges in simulating the folding of large proteins A Gershenson, S Gosavi, P Faccioli, PL Wintrode Journal of Biological Chemistry 295 (1), 15-33, 2020 | 62 | 2020 |
IL-1 family cytokines use distinct molecular mechanisms to signal through their shared co-receptor S Günther, D Deredge, AL Bowers, A Luchini, DA Bonsor, R Beadenkopf, ... Immunity 47 (3), 510-523. e4, 2017 | 61 | 2017 |
The Helicobacter pylori adhesin protein HopQ exploits the dimer interface of human CEACAMs to facilitate translocation of the oncoprotein CagA DA Bonsor, Q Zhao, B Schmidinger, E Weiss, J Wang, D Deredge, ... The EMBO journal 37 (13), e98664, 2018 | 60 | 2018 |
Complementary structural mass spectrometry techniques reveal local dynamics in functionally important regions of a metastable serpin X Zheng, PL Wintrode, MR Chance Structure 16 (1), 38-51, 2008 | 60 | 2008 |
The conformational dynamics of a metastable serpin studied by hydrogen exchange and mass spectrometry Y Tsutsui, L Liu, A Gershenson, PL Wintrode Biochemistry 45 (21), 6561-6569, 2006 | 60 | 2006 |