Jacques Pouyssegur
Jacques Pouyssegur
IRCAN, Centre A. Lacassagne, University of Nice and Centre Scientifique de Monaco (CSM)
Vahvistettu sähköpostiosoite verkkotunnuksessa unice.fr - Kotisivu
Tumor cell metabolism: cancer's Achilles' heel
G Kroemer, J Pouyssegur
Cancer cell 13 (6), 472-482, 2008
Hypoxia signalling in cancer and approaches to enforce tumour regression
J Pouysségur, F Dayan, NM Mazure
Nature 441 (7092), 437-443, 2006
Cyclin D1 expression is regulated positively by the p42/p44MAPK and negatively by the p38/HOGMAPK pathway
JN Lavoie, G L'Allemain, A Brunet, R Müller, J Pouysségur
Journal of Biological Chemistry 271 (34), 20608-20616, 1996
HIF prolyl‐hydroxylase 2 is the key oxygen sensor setting low steady‐state levels of HIF‐1α in normoxia
E Berra, E Benizri, A Ginouvès, V Volmat, D Roux, J Pouysségur
The EMBO journal 22 (16), 4082-4090, 2003
Mitogen-activated protein kinases p42mapk and p44mapk are required for fibroblast proliferation
G Pages, P Lenormand, G L'Allemain, JC Chambard, S Meloche, ...
Proceedings of the National Academy of Sciences 90 (18), 8319-8323, 1993
Hypoxia-induced autophagy is mediated through hypoxia-inducible factor induction of BNIP3 and BNIP3L via their BH3 domains
G Bellot, R Garcia-Medina, P Gounon, J Chiche, D Roux, J Pouysségur, ...
Molecular and cellular biology 29 (10), 2570-2581, 2009
The ERK1/2 mitogen-activated protein kinase pathway as a master regulator of the G1-to S-phase transition
S Meloche, J Pouysségur
Oncogene 26 (22), 3227-3239, 2007
p42/p44 mitogen-activated protein kinases phosphorylate hypoxia-inducible factor 1α (HIF-1α) and enhance the transcriptional activity of HIF-1
DE Richard, E Berra, E Gothié, D Roux, J Pouysségur
Journal of Biological Chemistry 274 (46), 32631-32637, 1999
Molecular cloning, primary structure, and expression of the human growth factor-activatable Na+ H+ antiporter
C Sardet, A Franchi, J Pouysségur
Cell 56 (2), 271-280, 1989
Defective thymocyte maturation in p44 MAP kinase (Erk 1) knockout mice
G Pagès, S Guérin, D Grall, F Bonino, A Smith, F Anjuere, P Auberger, ...
Science 286 (5443), 1374-1377, 1999
Growth factors induce nuclear translocation of MAP kinases (p42mapk and p44mapk) but not of their activator MAP kinase kinase (p45mapkk) in fibroblasts
P Lenormand, C Sardet, G Pages, G L'Allemain, A Brunet, J Pouysségur
The Journal of cell biology 122 (5), 1079-1088, 1993
Nonhypoxic pathway mediates the induction of hypoxia-inducible factor 1α in vascular smooth muscle cells
DE Richard, E Berra, J Pouysségur
Journal of Biological Chemistry 275 (35), 26765-26771, 2000
Prolyl hydroxylase-1 negatively regulates IκB kinase-β, giving insight into hypoxia-induced NFκB activity
EP Cummins, E Berra, KM Comerford, A Ginouves, KT Fitzgerald, ...
Proceedings of the National Academy of Sciences 103 (48), 18154-18159, 2006
ERK implication in cell cycle regulation
JC Chambard, R Lefloch, J Pouysségur, P Lenormand
Biochimica et Biophysica Acta (BBA)-Molecular Cell Research 1773 (8), 1299-1310, 2007
Fidelity and spatio-temporal control in MAP kinase (ERKs) signalling
J Pouysségur, V Volmat, P Lenormand
Biochemical pharmacology 64 (5-6), 755-763, 2002
Hypoxia and cancer
MC Brahimi-Horn, J Chiche, J Pouysségur
Journal of molecular medicine 85 (12), 1301-1307, 2007
Nuclear translocation of p42/p44 mitogen‐activated protein kinase is required for growth factor‐induced gene expression and cell cycle entry
A Brunet, D Roux, P Lenormand, S Dowd, S Keyse, J Pouysségur
The EMBO journal 18 (3), 664-674, 1999
Molecular physiology of vertebrate Na+/H+ exchangers
S Wakabayashi, M Shigekawa, J Pouyssegur
Physiological reviews 77 (1), 51-74, 1997
Hypoxia-inducible carbonic anhydrase IX and XII promote tumor cell growth by counteracting acidosis through the regulation of the intracellular pH
J Chiche, K Ilc, J Laferrière, E Trottier, F Dayan, NM Mazure, ...
Cancer research 69 (1), 358-368, 2009
A specific mutation abolishing Na+/H+ antiport activity in hamster fibroblasts precludes growth at neutral and acidic pH
J Pouysségur, C Sardet, A Franchi, G L'Allemain, S Paris
Proceedings of the National Academy of Sciences 81 (15), 4833-4837, 1984
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Artikkelit 1–20