|SCF/β-TrCP promotes glycogen synthase kinase 3-dependent degradation of the Nrf2 transcription factor in a Keap1-independent manner|
P Rada, AI Rojo, S Chowdhry, M McMahon, JD Hayes, A Cuadrado
Molecular and cellular biology 31 (6), 1121-1133, 2011
|Nrf2 is controlled by two distinct β-TrCP recognition motifs in its Neh6 domain, one of which can be modulated by GSK-3 activity|
S Chowdhry, Y Zhang, M McMahon, C Sutherland, A Cuadrado, ...
Oncogene 32 (32), 3765-3781, 2013
|Cancer chemoprevention mechanisms mediated through the Keap1–Nrf2 pathway|
JD Hayes, M McMahon, S Chowdhry, AT Dinkova-Kostova
Antioxidants & redox signaling 13 (11), 1713-1748, 2010
|Loss of Nrf2 markedly exacerbates nonalcoholic steatohepatitis|
S Chowdhry, MH Nazmy, PJ Meakin, AT Dinkova-Kostova, SV Walsh, ...
Free Radical Biology and Medicine 48 (2), 357-371, 2010
|Susceptibility of Nrf2-null mice to steatohepatitis and cirrhosis upon consumption of a high-fat diet is associated with oxidative stress, perturbation of the unfolded protein …|
PJ Meakin, S Chowdhry, RS Sharma, FB Ashford, SV Walsh, ...
Molecular and cellular biology 34 (17), 3305-3320, 2014
|Altered cellular metabolism in gliomas—An emerging landscape of actionable co-dependency targets|
J Bi, S Chowdhry, S Wu, W Zhang, K Masui, PS Mischel
Nature Reviews Cancer 20 (1), 57-70, 2020
|Neuronal development is promoted by weakened intrinsic antioxidant defences due to epigenetic repression of Nrf2|
KFS Bell, B Al-Mubarak, MA Martel, S McKay, N Wheelan, P Hasel, ...
Nature communications 6 (1), 7066, 2015
|NAD metabolic dependency in cancer is shaped by gene amplification and enhancer remodelling|
S Chowdhry, C Zanca, U Rajkumar, T Koga, Y Diao, R Raviram, F Liu, ...
Nature 569 (7757), 570-575, 2019
|Mild oxidative stress activates Nrf2 in astrocytes, which contributes to neuroprotective ischemic preconditioning|
KF Bell, B Al-Mubarak, JH Fowler, PS Baxter, K Gupta, T Tsujita, ...
Proceedings of the National Academy of Sciences 108 (1), E1-E2, 2011
|Dual regulation of transcription factor Nrf2 by Keap1 and by the combined actions of β-TrCP and GSK-3|
JD Hayes, S Chowdhry, AT Dinkova-Kostova, C Sutherland
Biochemical Society Transactions 43 (4), 611-620, 2015
|Oncogene amplification in growth factor signaling pathways renders cancers dependent on membrane lipid remodeling|
J Bi, TA Ichu, C Zanca, H Yang, W Zhang, Y Gu, S Chowdhry, A Reed, ...
Cell metabolism 30 (3), 525-538. e8, 2019
|Crosstalk between NRF2 and HIPK2 shapes cytoprotective responses|
L Torrente, C Sanchez, R Moreno, S Chowdhry, P Cabello, K Isono, ...
Oncogene 36 (44), 6204-6212, 2017
|Heat shock factor 1 is a substrate for p38 mitogen-activated protein kinases|
S Dayalan Naidu, C Sutherland, Y Zhang, A Risco, L de la Vega, ...
Molecular and cellular biology 36 (18), 2403-2417, 2016
|Nrf2 target genes can be controlled by neuronal activity in the absence of Nrf2 and astrocytes|
RF Deighton, NM Márkus, B Al-Mubarak, KFS Bell, S Papadia, PJ Meakin, ...
Proceedings of the National Academy of Sciences 111 (18), E1818-E1820, 2014
|Regulation of the CNC-bZIP transcription factor Nrf2 by Keap1 and the axis between GSK-3 and β-TrCP|
JD Hayes, K Ebisine, RS Sharma, S Chowdhry, AT Dinkova-Kostova, ...
Current Opinion in Toxicology 1, 92-103, 2016
|Molecular Characterization of Acquired Resistance to KRASG12C–EGFR Inhibition in Colorectal Cancer|
R Yaeger, R Mezzadra, J Sinopoli, Y Bian, M Marasco, E Kaplun, Y Gao, ...
Cancer discovery 13 (1), 41-55, 2023
|Non-canonical Keap1-independent activation of Nrf2 in astrocytes by mild oxidative stress|
BR Al-Mubarak, KFS Bell, S Chowdhry, PJ Meakin, PS Baxter, S McKay, ...
Redox biology 47, 102158, 2021
|Replication stress and the inability to repair damaged DNA, the potential “Achilles' heel” of ecDNA+ tumor cells|
S Chowdhry, S Garcia, NP Nguyen, A Celeste, E Tse, S Milutinovic, ...
Cancer Research 82 (12_Supplement), 1520-1520, 2022
|Abstract B082: A novel, potent and selective ribonucleotide reductase (RNR) inhibitor, BBI-825, blocks extrachromosomal DNA (ecDNA) amplification-mediated resistance to …|
S Chowdhry, R Hansen, J Mauger, AM Pferdekamper, E Tse, B Norman, ...
Molecular Cancer Therapeutics 22 (12_Supplement), B082-B082, 2023
|682P Preclinical and ongoing phase I study data of the CHK1 inhibitor BBI-355 in development for patients with oncogene amplification on extrachromosomal DNA (ecDNA)|
A Drilon, IIR Rivera, AI Spira, MR Sharma, R Hansen, S Chowdhry, ...
Annals of Oncology 34, S477, 2023