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Gorakh Jachak
Gorakh Jachak
Postdoctoral Researcher, University of Minnesota
Verified email at umn.edu
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Cited by
Cited by
Year
Silicon incorporated morpholine antifungals: design, synthesis, and biological evaluation
GR Jachak, R Ramesh, DG Sant, SU Jorwekar, MR Jadhav, SG Tupe, ...
ACS Medicinal Chemistry Letters 6 (11), 1111-1116, 2015
482015
Specific stereoisomeric conformations determine the drug potency of cladosporin scaffold against malarial parasite
P Das, P Babbar, N Malhotra, M Sharma, GR Jachak, RG Gonnade, ...
Journal of Medicinal Chemistry 61 (13), 5664-5678, 2018
462018
Repurposing Ivacaftor for treatment of Staphylococcus aureus infections
R Thakare, AK Singh, S Das, N Vasudevan, GR Jachak, DS Reddy, ...
International journal of antimicrobial agents 50 (3), 389-392, 2017
362017
Total synthesis of the marine natural product solomonamide B necessitates stereochemical revision
K Kashinath, GR Jachak, PR Athawale, UK Marelli, RG Gonnade, ...
Organic letters 18 (13), 3178-3181, 2016
322016
Identification of new anti-inflammatory agents based on nitrosporeusine natural products of marine origin
SC Philkhana, AK Verma, GR Jachak, B Hazra, A Basu, DS Reddy
European Journal of Medicinal Chemistry 135, 89-109, 2017
192017
First synthesis of nitrosporeusines, alkaloids with multiple biological activities
SC Philkhana, GR Jachak, VB Gunjal, NM Dhage, AH Bansode, ...
Tetrahedron letters 56 (10), 1252-1254, 2015
162015
Total synthesis of the potent anti-inflammatory natural product solomonamide A along with structural revision and biological activity evaluation
GR Jachak, PR Athawale, H Agarwal, MK Barthwal, G Lauro, G Bifulco, ...
Organic & Biomolecular Chemistry 16 (47), 9138-9142, 2018
122018
Breaking and Making of Rings: A Method for the Preparation of 4‐Quinolone‐3‐carboxylic Acid Amides and the Expensive Drug Ivacaftor
N Vasudevan, GR Jachak, DS Reddy
European Journal of Organic Chemistry 2015 (34), 7433-7437, 2015
122015
Efforts towards the synthesis of microsporin B: ready access to both the enantiomers of the key amino acid fragment
PS Swaroop, S Tripathy, G Jachak, DS Reddy
Tetrahedron letters 55 (34), 4777-4779, 2014
82014
Access to a Stereoisomer Library of Solomonamide Macrocycles
GR Jachak, PR Athawale, R Choudhury, K Kashinath, DS Reddy
Chemistry–An Asian Journal 14 (24), 4572-4576, 2019
72019
Efforts To Access the Potent Antitrypanosomal Marine Natural Product Janadolide: Synthesis of Des-tert-butyl Janadolide and Its Biological Evaluation
PR Athawale, GR Jachak, A Shukla, D Shanmugam, DS Reddy
ACS omega 3 (2), 2383-2389, 2018
72018
Identification of 5‑(Aryl/Heteroaryl)amino-4-quinolones as Potent Membrane-Disrupting Agents to Combat Antibiotic-Resistant GramPositive Bacteria
CCA John R. Schultz, Stephen K. Costa, Gorakhnath R. Jachak, Pooja Hegde ...
Journal of medicinal chemistry, 2022
62022
Nitrosporeusine analogue ameliorates Chandipura virus induced inflammatory response in CNS via NFκb inactivation in microglia
AK Verma, TS Waghmare, GR Jachak, SC Philkhana, DS Reddy, A Basu
PLoS Neglected Tropical Diseases 12 (7), e0006648, 2018
62018
Stereocontrolled Synthesis of Pseurotin A2
GRJ Prabhakara R. Tharra, Petr Sevelda, Jakub Švenda
The Journal of Organic Chemistry 86, 11845, 2021
4*2021
Scalable Synthesis of Both Enantiomers of Vigabatrin, an Antiepileptic Drug
GR Jachak, DS Reddy
European Journal of Organic Chemistry 2019 (6), 1257-1260, 2019
42019
Gram Scale Synthesis of Membrane-Active Antibacterial 4-Quinolone Lead Compound
GR Jachak, MO Orimoloye, CC Aldrich
The Journal of Organic Chemistry 88 (9), 6209-6217, 2023
32023
Structure activity relationship of pyrazinoic acid analogs as potential antimycobacterial agents
CCA Pooja V. Hegde, Wassihun W. Aragaw, Malcolm S. Col, Gorakhnath Jachak ...
Bioorganic & Medicinal Chemistry, 2022
32022
Comprehensive Study on Solomonamides: Total Synthesis, Stereochemical Revision, and SAR Studies toward Identification of Simplified Lead
GR Jachak, K Kashinath, N Vasudevan, PR Athawale, R Choudhury, ...
The Journal of Organic Chemistry 88 (24), 17088-17133, 2023
12023
Synthesis and Biological Evaluation of Hoshionolactam‐Based Compounds
GR Jachak, D Elizebath, A Shukla, D Shanmugam, DS Reddy
European Journal of Organic Chemistry 2021 (15), 2212-2218, 2021
12021
Process for the synthesis of ivacaftor and related compounds
DS Reddy, V Natarajan, GR Jachak
US Patent 10,336,703, 2019
12019
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Articles 1–20