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Maciej Dobrzyński
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Frequency modulation of ERK activation dynamics rewires cell fate
H Ryu, M Chung, M Dobrzyński, D Fey, Y Blum, SS Lee, M Peter, ...
Molecular systems biology 11 (11), 838, 2015
1852015
Elongation dynamics shape bursty transcription and translation
M Dobrzyński, FJ Bruggeman
Proceedings of the National Academy of Sciences 106 (8), 2583-2588, 2009
1392009
Bistability in the Rac1, PAK, and RhoA signaling network drives actin cytoskeleton dynamics and cell motility switches
KM Byrne, N Monsefi, JC Dawson, A Degasperi, JC Bukowski-Wills, ...
Cell systems 2 (1), 38-48, 2016
1352016
Spatial stochastic modelling of the phosphoenolpyruvate-dependent phosphotransferase (PTS) pathway in Escherichia coli
JV Rodriguez, JA Kaandorp, M Dobrzyński, JG Blom
Bioinformatics 22 (15), 1895-1901, 2006
1162006
Emergence of bimodal cell population responses from the interplay between analog single-cell signaling and protein expression noise
MR Birtwistle, J Rauch, A Kiyatkin, E Aksamitiene, M Dobrzyński, JB Hoek, ...
BMC systems biology 6 (1), 1-12, 2012
902012
Computational methods for diffusion-influenced biochemical reactions
M Dobrzyński, JV Rodríguez, JA Kaandorp, JG Blom
Bioinformatics 23 (15), 1969-1977, 2007
742007
Collective ERK/Akt activity waves orchestrate epithelial homeostasis by driving apoptosis-induced survival
PA Gagliardi, M Dobrzyński, MA Jacques, C Dessauges, P Ender, Y Blum, ...
Developmental cell 56 (12), 1712-1726. e6, 2021
462021
Polyubiquitin chain assembly and organisation determine the dynamics of protein activation and degradation
LK Nguyen, M Dobrzynski, D Fey, BN Kholodenko
Frontiers in Physiology, 0, 2014
312014
Temporal perturbation of ERK dynamics reveals network architecture of FGF2/MAPK signaling
Y Blum, J Mikelson, M Dobrzyński, H Ryu, MA Jacques, NL Jeon, ...
Molecular systems biology 15 (11), e8947, 2019
292019
Nonlinear signalling networks and cell-to-cell variability transform external signals into broadly distributed or bimodal responses
M Dobrzyński, LK Nguyen, MR Birtwistle, A von Kriegsheim, ...
Journal of The Royal Society Interface 11 (98), 20140383, 2014
282014
Origins of stochastic intracellular processes and consequences for cell-to-cell variability and cellular survival strategies
A Schwabe, M Dobrzyński, K Rybakova, P Verschure, FJ Bruggeman
Methods in enzymology 500, 597-625, 2011
232011
Proteomics analysis of bladder cancer invasion: targeting EIF3D for therapeutic intervention
A Latosinska, M Mokou, M Makridakis, W Mullen, J Zoidakis, V Lygirou, ...
Oncotarget 8 (41), 69435, 2017
212017
Strategies for structuring interdisciplinary education in Systems Biology: an European perspective
M Cvijovic, T Höfer, J Aćimović, L Alberghina, E Almaas, D Besozzi, ...
NPJ systems biology and applications 2 (1), 1-7, 2016
182016
Mammalian protein expression noise: scaling principles and the implications for knockdown experiments
MR Birtwistle, A Von Kriegsheim, M Dobrzyński, BN Kholodenko, W Kolch
Molecular BioSystems 8 (11), 3068-3076, 2012
142012
Mining single-cell time-series datasets with Time Course Inspector
M Dobrzyński, MA Jacques, O Pertz
Bioinformatics 36 (6), 1968-1969, 2020
132020
CODEX, a neural network approach to explore signaling dynamics landscapes
MA Jacques, M Dobrzyński, PA Gagliardi, R Sznitman, O Pertz
Molecular systems biology 17 (4), e10026, 2021
102021
Bimodal Protein Distributions in Heterogeneous Oscillating Systems
M Dobrzyński, D Fey, LK Nguyen, BN Kholodenko
Computational Methods in Systems Biology, 10th International Conference …, 2012
102012
Evolution of bet-hedging mechanisms in cell cycle and embryo development stimulated by weak linkage of stochastic processes
M Dobrzyński, P Bernatowicz, M Kloc, JZ Kubiak
Cell cycle in development, 11-30, 2011
72011
When do diffusion-limited trajectories become memoryless?
M Dobrzynski, R Gauges, U Kummer, J Pahle, PM Willy
Proceedings of the 5th Workshop on Computation of Biochemical Pathways and …, 2008
62008
Optogenetic actuator/biosensor circuits for large-scale interrogation of ERK dynamics identify sources of MAPK signaling robustness
C Dessauges, J Mikelson, M Dobrzyński, MA Jacques, A Frismantiene, ...
BioRxiv, 2021
52021
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Articles 1–20