| Chroman-4-one-and chromone-based sirtuin 2 inhibitors with antiproliferative properties in cancer cells T Seifert, M Malo, T Kokkola, K Engen, M Friden-Saxin, EAA Wallen, ... Journal of Medicinal Chemistry 57 (23), 9870-9888, 2014 | 109 | 2014 |
| Oxadiazole-carbonylaminothioureas as SIRT1 and SIRT2 inhibitors T Huhtiniemi, T Suuronen, VM Rinne, C Wittekindt, M Lahtela-Kakkonen, ... Journal of medicinal chemistry 51 (15), 4377-4380, 2008 | 103 | 2008 |
| Inhibitors and promoters of tubulin polymerization: Synthesis and biological evaluation of chalcones and related dienones as potential anticancer agents C Dyrager, M Wickström, M Fridén-Saxin, A Friberg, K Dahlén, ... Bioorganic & medicinal chemistry 19 (8), 2659-2665, 2011 | 94 | 2011 |
| A cyclopent-2-enecarbonyl group mimics proline at the P2 position of prolyl oligopeptidase inhibitors EM Jarho, JI Venäläinen, J Huuskonen, JAM Christiaans, ... Journal of medicinal chemistry 47 (23), 5605-5607, 2004 | 83 | 2004 |
| Synthesis of 2, 3, 6, 8-tetrasubstituted chromone scaffolds K Dahlen, EAA Wallen, M Grøtli, K Luthman The Journal of Organic Chemistry 71 (18), 6863-6871, 2006 | 74 | 2006 |
| Nϵ-Thioacetyl-Lysine-Containing Tri-, Tetra-, and Pentapeptides as SIRT1 and SIRT2 Inhibitors PH Kiviranta, T Suuronen, EAA Wallén, J Leppanen, J Tervonen, ... Journal of medicinal chemistry 52 (7), 2153-2156, 2009 | 72 | 2009 |
| Binding kinetics and duration of in vivo action of novel prolyl oligopeptidase inhibitors JI Venäläinen, JA Garcia-Horsman, MM Forsberg, A Jalkanen, ... Biochemical pharmacology 71 (5), 683-692, 2006 | 72 | 2006 |
| N-(3-(4-Hydroxyphenyl)-propenoyl)-amino acid tryptamides as SIRT2 inhibitors PH Kiviranta, J Leppänen, VM Rinne, T Suuronen, O Kyrylenko, ... Bioorganic & medicinal chemistry letters 17 (9), 2448-2451, 2007 | 66 | 2007 |
| Beneficial effect of prolyl oligopeptidase inhibition on spatial memory in young but not in old scopolamine‐treated rats AJ Jalkanen, KA Puttonen, JI Venäläinen, V Sinervä, A Mannila, ... Basic & clinical pharmacology & toxicology 100 (2), 132-138, 2007 | 63 | 2007 |
| Substrate-dependent, non-hyperbolic kinetics of pig brain prolyl oligopeptidase and its tight binding inhibition by JTP-4819 JI Venäläinen, RO Juvonen, MM Forsberg, A Garcia-Horsman, A Poso, ... Biochemical pharmacology 64 (3), 463-471, 2002 | 63 | 2002 |
| 4-Phenylbutanoyl-2 (S)-acylpyrrolidines and 4-phenylbutanoyl-L-prolyl-2 (S)-acylpyrrolidines as prolyl oligopeptidase inhibitors EAA Wallén, JAM Christiaans, SM Saario, MM Forsberg, JI Venäläinen, ... Bioorganic & medicinal chemistry 10 (7), 2199-2206, 2002 | 61 | 2002 |
| N,N‘-Bisbenzylidenebenzene-1,4-diamines and N,N‘-Bisbenzylidenenaphthalene-1,4-diamines as Sirtuin Type 2 (SIRT2) Inhibitors PH Kiviranta, J Leppänen, S Kyrylenko, HS Salo, M Lahtela-Kakkonen, ... Journal of medicinal chemistry 49 (26), 7907-7911, 2006 | 53 | 2006 |
| Dicarboxylic acid bis (L-prolyl-pyrrolidine) amides as prolyl oligopeptidase inhibitors EAA Wallén, JAM Christiaans, MM Forsberg, JI Venäläinen, PT Männistö, ... Journal of medicinal chemistry 45 (20), 4581-4584, 2002 | 52 | 2002 |
| Synthesis of 3-aminomethyl-2-aryl-8-bromo-6-chlorochromones EAA Wallén, K Dahlén, M Grøtli, K Luthman Organic Letters 9 (3), 389-391, 2007 | 39 | 2007 |
| New prolyl oligopeptidase inhibitors developed from dicarboxylic acid bis (l-prolyl-pyrrolidine) amides EAA Wallén, JAM Christiaans, EM Jarho, MM Forsberg, JI Venäläinen, ... Journal of medicinal chemistry 46 (21), 4543-4551, 2003 | 35 | 2003 |
| Slow-binding inhibitors of prolyl oligopeptidase with different functional groups at the P1 site JI Venäläinen, RO Juvonen, JA Garcia-Horsman, EAA WALLéN, ... Biochemical Journal 382 (3), 1003-1008, 2004 | 32 | 2004 |
| Conformationally rigid N-acyl-5-alkyl-L-prolyl-pyrrolidines as prolyl oligopeptidase inhibitors EAA Wallén, JAM Christiaans, TJ Saarinen, EM Jarho, MM Forsberg, ... Bioorganic & medicinal chemistry 11 (17), 3611-3619, 2003 | 31 | 2003 |
| Characterization of the binding properties of SIRT2 inhibitors with a N-(3-phenylpropenoyl)-glycine tryptamide backbone PH Kiviranta, HS Salo, J Leppänen, VM Rinne, S Kyrylenko, E Kuusisto, ... Bioorganic & medicinal chemistry 16 (17), 8054-8062, 2008 | 25 | 2008 |
| Azulene-based compounds for targeting orexin receptors TO Leino, A Turku, J Yli-Kauhaluoma, JP Kukkonen, H Xhaard, ... European Journal of Medicinal Chemistry 157, 88-100, 2018 | 24 | 2018 |
| Dicarboxylic Acid Azacycle l-Prolyl-pyrrolidine Amides as Prolyl Oligopeptidase Inhibitors and Three-Dimensional Quantitative Structure−Activity Relationship of the … EM Jarho, EAA Wallén, JAM Christiaans, MM Forsberg, JI Venäläinen, ... Journal of medicinal chemistry 48 (15), 4772-4782, 2005 | 24 | 2005 |
