Sensitive red protein calcium indicators for imaging neural activity H Dana, B Mohar, Y Sun, S Narayan, A Gordus, JP Hasseman, ...
Elife 5, e12727, 2016
951 2016 Axonal Endoplasmic Reticulum Ca2+ Content Controls Release Probability in CNS Nerve Terminals J de Juan-Sanz, GT Holt, ER Schreiter, F de Juan, DS Kim, TA Ryan
Neuron 93 (4), 867-881. e6, 2017
238 2017 Improved methods for marking active neuron populations B Moeyaert, G Holt, R Madangopal, A Perez-Alvarez, BC Fearey, ...
Nature communications 9 (1), 1-12, 2018
120 2018 A low affinity GCaMP3 variant (GCaMPer) for imaging the endoplasmic reticulum calcium store MJ Henderson, HA Baldwin, CA Werley, S Boccardo, LR Whitaker, X Yan, ...
PLoS One 10 (10), e0139273, 2015
76 2015 OSPREY 3.0: Open‐source protein redesign for you, with powerful new features MA Hallen, JW Martin, A Ojewole, JD Jou, AU Lowegard, MS Frenkel, ...
Journal of Computational Chemistry 39 (30), 2494-2507, 2018
67 2018 Toward Broad Spectrum Dihydrofolate Reductase Inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin Resistant Staphylococcus aureus SM Reeve, D Si, J Krucinska, Y Yan, K Viswanathan, S Wang, GT Holt, ...
ACS infectious diseases 5 (11), 1896-1906, 2019
14 2019 Novel, provable algorithms for efficient ensemble-based computational protein design and their application to the redesign of the c-Raf-RBD: KRas protein-protein interface AU Lowegard, MS Frenkel, GT Holt, JD Jou, AA Ojewole, BR Donald
PLOS Computational Biology 16 (6), e1007447, 2020
13 2020 Computational analysis of energy landscapes reveals dynamic features that contribute to binding of inhibitors to CFTR-associated ligand GT Holt, JD Jou, NP Gill, AU Lowegard, JW Martin, DR Madden, ...
The Journal of Physical Chemistry B 123 (49), 10441-10455, 2019
9 2019 Minimization-Aware Recursive K*: A Novel, Provable Algorithm that Accelerates Ensemble-Based Protein Design and Provably Approximates the Energy Landscape JD Jou, GT Holt, AU Lowegard, BR Donald
Journal of Computational Biology 27 (4), 550-564, 2020
8 2020 Chiral evasion and stereospecific antifolate resistance in Staphylococcus aureus S Wang, SM Reeve, GT Holt, AA Ojewole, MS Frenkel, P Gainza, ...
PLoS computational biology 18 (2), e1009855, 2022
7 2022 Minimization-Aware Recursive JD Jou, GT Holt, AU Lowegard, BR Donald
Research in Computational Molecular Biology: 23rd Annual International …, 2019
3 2019 Improved HIV-1 neutralization breadth and potency of V2-apex antibodies by in silico design GT Holt, J Gorman, S Wang, AU Lowegard, B Zhang, T Liu, BC Lin, ...
Cell Reports 42 (7), 112711, 2023
2 2023 Toward Broad Spectrum DHFR inhibitors Targeting Trimethoprim Resistant Enzymes Identified in Clinical Isolates of Methicillin-Resistant Staphylococcus aureus SM Reeve, D Si, J Krucinska, Y Yan, K Viswanathan, S Wang, GT Holt, ...
ACS infectious diseases 5 (11), 1896, 2019
2 2019 Improved red protein indicators for in vivo calcium imaging H Dana, Y Sun, JP Hasseman, G Tsegaye, GT Holt, BF Fosque, ...
Program#/Poster 566, 2014
2 2014 Ensemble-based Computational Protein Design: Novel Algorithms and Applications to Energy Landscape Approximation, Antibiotic Resistance, and Antibody Design GT Holt
2022 