Steven O. Simmons
Steven O. Simmons
US EPA Office of Research and Development
Verified email at
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Cellular stress response pathway system as a sentinel ensemble in toxicological screening
SO Simmons, CY Fan, R Ramabhadran
Toxicological sciences 111 (2), 202-225, 2009
Gene expression changes in developing zebrafish as potential markers for rapid developmental neurotoxicity screening
CY Fan, J Cowden, SO Simmons, S Padilla, R Ramabhadran
Neurotoxicology and teratology 32 (1), 91-98, 2010
Nrf2 expression modifies influenza A entry and replication in nasal epithelial cells
MJ Kesic, SO Simmons, R Bauer, I Jaspers
Free Radical Biology and Medicine 51 (2), 444-453, 2011
High-throughput genotoxicity assay identifies antioxidants as inducers of DNA damage response and cell death
JT Fox, S Sakamuru, R Huang, N Teneva, SO Simmons, M Xia, RR Tice, ...
Proceedings of the National Academy of Sciences 109 (14), 5423-5428, 2012
NRF2 oxidative stress induced by heavy metals is cell type dependent
SO Simmons, CY Fan, K Yeoman, J Wakefield, R Ramabhadran
Current chemical genomics 5, 1, 2011
Investigating oxidative stress and inflammatory responses elicited by silver nanoparticles using high-throughput reporter genes in HepG2 cells: effect of size, surface coating …
RY Prasad, JK McGee, MG Killius, DA Suarez, CF Blackman, ...
Toxicology in vitro 27 (6), 2013
The next generation blueprint of computational toxicology at the US Environmental Protection Agency
RS Thomas, T Bahadori, TJ Buckley, J Cowden, C Deisenroth, ...
Toxicological Sciences 169 (2), 317-332, 2019
Differential transcriptional regulation of IL-8 expression by human airway epithelial cells exposed to diesel exhaust particles
TL Tal, SO Simmons, R Silbajoris, L Dailey, SH Cho, R Ramabhadran, ...
Toxicology and applied pharmacology 243 (1), 46-54, 2010
Tiered high-throughput screening approach to identify thyroperoxidase inhibitors within the ToxCast phase I and II chemical libraries
K Paul Friedman, ED Watt, MW Hornung, JM Hedge, RS Judson, ...
Toxicological Sciences 151 (1), 160-180, 2016
Development of a thyroperoxidase inhibition assay for high-throughput screening
KB Paul, JM Hedge, DM Rotroff, MW Hornung, KM Crofton, SO Simmons
Chemical research in toxicology 27 (3), 387-399, 2014
Ambient particulate matter induces interleukin-8 expression through an alternative NF-κB (nuclear factor-kappa B) mechanism in human airway epithelial cells
R Silbajoris, AR Osornio-Vargas, SO Simmons, W Reed, PA Bromberg, ...
Environmental health perspectives 119 (10), 1379-1383, 2011
Evidence for triclosan-induced activation of human and rodent xenobiotic nuclear receptors
KB Paul, JT Thompson, SO Simmons, JPV Heuvel, KM Crofton
Toxicology In Vitro 27 (7), 2049-2060, 2013
Linking oxidative events to inflammatory and adaptive gene expression induced by exposure to an organic particulate matter component
WY Cheng, J Currier, PA Bromberg, R Silbajoris, SO Simmons, JM Samet
Environmental Health Perspectives 120 (2), 267-274, 2012
Sumoylation of internally initiated Sp3 isoforms regulates transcriptional repression via a Trichostatin A-insensitive mechanism
ML Spengler, SB Kennett, KS Moorefield, SO Simmons, MG Brattain, ...
Cellular signalling 17 (2), 153-166, 2005
Development of a screening approach to detect thyroid disrupting chemicals that inhibit the human sodium iodide symporter (NIS)
DR Hallinger, AS Murr, AR Buckalew, SO Simmons, TE Stoker, SC Laws
Toxicology in vitro 40, 66-78, 2017
Profiling environmental chemicals for activity in the antioxidant response element signaling pathway using a high throughput screening approach
SJ Shukla, R Huang, SO Simmons, RR Tice, KL Witt, D VanLeer, ...
Environmental health perspectives 120 (8), 1150-1156, 2012
Cross-species analysis of thyroperoxidase inhibition by xenobiotics demonstrates conservation of response between pig and rat
KB Paul, JM Hedge, C Macherla, DL Filer, E Burgess, SO Simmons, ...
Toxicology 312, 97-107, 2013
Nkx3. 1 binds and negatively regulates the transcriptional activity of Sp-family members in prostate-derived cells
SO Simmons, JM Horowitz
Biochemical Journal 393 (1), 397-409, 2006
“Green” synthesized and coated nanosilver alters the membrane permeability of barrier (intestinal, brain endothelial) cells and stimulates oxidative stress pathways in neurons
B Baruwati, SO Simmons, RS Varma, B Veronesi
ACS Sustainable Chemistry & Engineering 1 (7), 753-759, 2013
High-throughput screening and quantitative chemical ranking for sodium-iodide symporter inhibitors in ToxCast phase I chemical library
J Wang, DR Hallinger, AS Murr, AR Buckalew, SO Simmons, SC Laws, ...
Environmental science & technology 52 (9), 5417-5426, 2018
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