R406, an orally available spleen tyrosine kinase inhibitor blocks fc receptor signaling and reduces immune complex-mediated inflammation S Braselmann, V Taylor, H Zhao, S Wang, C Sylvain, M Baluom, K Qu, ... Journal of Pharmacology and Experimental Therapeutics 319 (3), 998-1008, 2006 | 588 | 2006 |
Broad-spectrum antivirals against 3C or 3C-like proteases of picornaviruses, noroviruses, and coronaviruses Y Kim, S Lovell, KC Tiew, SR Mandadapu, KR Alliston, KP Battaile, ... Journal of virology 86 (21), 11754-11762, 2012 | 363 | 2012 |
3C-like protease inhibitors block coronavirus replication in vitro and improve survival in MERS-CoV–infected mice AD Rathnayake, J Zheng, Y Kim, KD Perera, S Mackin, DK Meyerholz, ... Science translational medicine 12 (557), eabc5332, 2020 | 227 | 2020 |
Molecular basis for the high-affinity binding and stabilization of firefly luciferase by PTC124 DS Auld, S Lovell, N Thorne, WA Lea, DJ Maloney, M Shen, G Rai, ... Proceedings of the National Academy of Sciences 107 (11), 4878-4883, 2010 | 194 | 2010 |
The Min oscillator uses MinD-dependent conformational changes in MinE to spatially regulate cytokinesis KT Park, W Wu, KP Battaile, S Lovell, T Holyoak, J Lutkenhaus Cell 146 (3), 396-407, 2011 | 171 | 2011 |
Intrinsic barriers for electron and hydrogen atom transfer reactions of biomimetic iron complexes JP Roth, S Lovell, JM Mayer Journal of the American Chemical Society 122 (23), 5486-5498, 2000 | 161 | 2000 |
Firefly luciferase in chemical biology: a compendium of inhibitors, mechanistic evaluation of chemotypes, and suggested use as a reporter N Thorne, M Shen, WA Lea, A Simeonov, S Lovell, DS Auld, J Inglese Chemistry & biology 19 (8), 1060-1072, 2012 | 148 | 2012 |
C−N Bond Formation on Addition of Aryl Carbanions to the Electrophilic Nitrido Ligand in TpOs(N)Cl2 TJ Crevier, BK Bennett, JD Soper, JA Bowman, A Dehestani, DA Hrovat, ... Journal of the American Chemical Society 123 (6), 1059-1071, 2001 | 140 | 2001 |
Hydrocarbon oxidation by bis-μ-oxo manganese dimers: Electron transfer, hydride transfer, and hydrogen atom transfer mechanisms AS Larsen, K Wang, MA Lockwood, GL Rice, TJ Won, S Lovell, M Sadílek, ... Journal of the American Chemical Society 124 (34), 10112-10123, 2002 | 134 | 2002 |
Structure-guided design of potent and permeable inhibitors of MERS coronavirus 3CL protease that utilize a piperidine moiety as a novel design element ACG Kankanamalage, Y Kim, VC Damalanka, AD Rathnayake, AR Fehr, ... European journal of medicinal chemistry 150, 334-346, 2018 | 114 | 2018 |
Solid-Phase Synthesis and Structural Analysis of Bicyclic β-Turn Mimetics Incorporating Functionality at the i to i + 3 Positions M Eguchi, MS Lee, H Nakanishi, M Stasiak, S Lovell, M Kahn Journal of the American Chemical Society 121 (51), 12204-12205, 1999 | 102 | 1999 |
The structural determination of an insect sterol carrier protein-2 with a ligand-bound C16 fatty acid at 1.35-Å resolution DH Dyer, S Lovell, JB Thoden, HM Holden, I Rayment, Q Lan Journal of Biological Chemistry 278 (40), 39085-39091, 2003 | 98 | 2003 |
Two-metal active site binding of a Tn5 transposase synaptic complex S Lovell, IY Goryshin, WR Reznikoff, I Rayment nature structural biology 9 (4), 278-281, 2002 | 98 | 2002 |
The SARS-CoV-2 conserved macrodomain is a mono-ADP-ribosylhydrolase YMO Alhammad, MM Kashipathy, A Roy, JP Gagné, P McDonald, P Gao, ... Journal of virology 95 (3), 10.1128/jvi. 01969-20, 2021 | 97 | 2021 |
The structure of the BfrB–Bfd complex reveals protein–protein interactions enabling iron release from bacterioferritin H Yao, Y Wang, S Lovell, R Kumar, AM Ruvinsky, KP Battaile, IA Vakser, ... Journal of the American Chemical Society 134 (32), 13470-13481, 2012 | 94 | 2012 |
How do oxidized thiolate ligands affect the electronic and reactivity properties of a nitrile hydratase model compound? I Kung, D Schweitzer, J Shearer, WD Taylor, HL Jackson, S Lovell, ... Journal of the American Chemical Society 122 (34), 8299-8300, 2000 | 85 | 2000 |
Reconfiguration of the proteasome during chaperone-mediated assembly S Park, X Li, HM Kim, CR Singh, G Tian, MA Hoyt, S Lovell, KP Battaile, ... Nature 497 (7450), 512-516, 2013 | 84 | 2013 |
Binding of Pseudomonas aeruginosa Apobacterioferritin-Associated Ferredoxin to Bacterioferritin B Promotes Heme Mediation of Electron Delivery and … SK Weeratunga, CE Gee, S Lovell, Y Zeng, CL Woodin, M Rivera Biochemistry 48 (31), 7420-7431, 2009 | 84 | 2009 |
Structural Studies of Bacterioferritin B from Pseudomonas aeruginosa Suggest a Gating Mechanism for Iron Uptake via the Ferroxidase Center, SK Weeratunga, S Lovell, H Yao, KP Battaile, CJ Fischer, CE Gee, ... Biochemistry 49 (6), 1160-1175, 2010 | 83 | 2010 |
The plug-based nanovolume microcapillary protein crystallization system (MPCS) CJ Gerdts, M Elliott, S Lovell, MB Mixon, AJ Napuli, BL Staker, P Nollert, ... Acta Crystallographica Section D: Biological Crystallography 64 (11), 1116-1122, 2008 | 82 | 2008 |