Giambattista Guaitoli
Giambattista Guaitoli
DZNE - Deutsches Zentrum Neurodegerative Erkrankungen
Vahvistettu sähköpostiosoite verkkotunnuksessa dzne.de - Kotisivu
NimikeViittauksetVuosi
Protein–protein interface-binding peptides inhibit the cancer therapy target human thymidylate synthase
D Cardinale, G Guaitoli, D Tondi, R Luciani, S Henrich, OMH Salo-Ahen, ...
Proceedings of the National Academy of Sciences 108 (34), E542-E549, 2011
662011
Structural model of the dimeric Parkinson’s protein LRRK2 reveals a compact architecture involving distant interdomain contacts
G Guaitoli, F Raimondi, BK Gilsbach, Y Gómez-Llorente, E Deyaert, ...
Proceedings of the National Academy of Sciences 113 (30), E4357-E4366, 2016
612016
Ligand-based virtual screening and ADME-tox guided approach to identify triazolo-quinoxalines as folate cycle inhibitors
E Carosati, G Sforna, M Pippi, G Marverti, A Ligabue, D Guerrieri, S Piras, ...
Bioorganic & medicinal chemistry 18 (22), 7773-7785, 2010
232010
A homologue of the Parkinson’s disease-associated protein LRRK2 undergoes a monomer-dimer transition during GTP turnover
E Deyaert, L Wauters, G Guaitoli, A Konijnenberg, M Leemans, ...
Nature communications 8 (1), 1008, 2017
202017
Inhibitor of ovarian cancer cells growth by virtual screening: a new thiazole derivative targeting human thymidylate synthase
E Carosati, A Tochowicz, G Marverti, G Guaitoli, P Benedetti, S Ferrari, ...
Journal of medicinal chemistry 55 (22), 10272-10276, 2012
182012
Dimer–monomer equilibrium of human thymidylate synthase monitored by fluorescence resonance energy transfer
F Genovese, S Ferrari, G Guaitoli, M Caselli, MP Costi, G Ponterini
Protein Science 19 (5), 1023-1030, 2010
172010
A combinatorial approach to identify calpain cleavage sites in the Machado-Joseph disease protein ataxin-3
JJ Weber, M Golla, G Guaitoli, P Wanichawan, SN Hayer, S Hauser, ...
Brain 140 (5), 1280-1299, 2017
132017
Distamycin A and derivatives as synergic drugs in cisplatin-sensitive and-resistant ovarian cancer cells
G Marverti, G Guaitoli, A Ligabue, C Frassineti, MG Monti, P Lombardi, ...
Amino Acids 42 (2-3), 641-653, 2012
82012
Alanine mutants of the interface residues of human thymidylate synthase decode key features of the binding mode of allosteric anticancer peptides
A Tochowicz, M Santucci, P Saxena, G Guaitoli, M Trande, J Finer-Moore, ...
Journal of medicinal chemistry 58 (2), 1012-1018, 2014
72014
Design and characterization of a mutation outside the active site of human thymidylate synthase that affects ligand binding
D Cardinale, OMH Salo-Ahen, G Guaitoli, S Ferrari, A Venturelli, ...
Protein Engineering, Design & Selection 23 (2), 81-89, 2009
62009
First model of dimeric LRRK2: the challenge of unrevealing the structure of a multidomain Parkinson's-associated protein
G Guaitoli, BK Gilsbach, F Raimondi, CJ Gloeckner
Biochemical Society Transactions 44 (6), 1635-1641, 2016
32016
Biochemical and kinetic properties of the complex Roco G-protein cycle
L Wauters, S Terheyden, BK Gilsbach, M Leemans, PS Athanasopoulos, ...
Biological chemistry 399 (12), 1447-1456, 2018
22018
Biochemical and kinetic properties of the complex Roco G-protein cycle
L Wauters, S Terheyden, BK Gilsbach, M Leemans, PS Athanasopoulos, ...
Biological chemistry 399 (12), 1447-1456, 2018
22018
Auto-regulation of Rab5 GEF activity in Rabex5 by allosteric structural changes, catalytic core dynamics and ubiquitin binding
J Lauer, S Segeletz, A Cezanne, G Guaitoli, F Raimondi, M Gentzel, ...
eLife 8, 2019
2019
Allosteric structural alterations and auto-regulation of Rab5 GEF activity in Rabex5
J Lauer, A Cezanne, G Guaitoli, F Raimondi, M Gentzel, V Alva, M Habeck, ...
BioRxiv, 562504, 2019
2019
Zing meeting on Medicinal Chemistry 2012-Lanzarote-invitated lecture
MP Costi, S Ferrari, G Ponterini, D Cardinale, G Guaitoli, D Tondi
Zing meeting on Medicinal Chemistry 2012-Lanzarote, 1-1, 2012
2012
Crystal Structure of human thymidylate synthase bound to a peptide inhibitor
C Pozzi, D Cardinale, G Guaitoli, D Tondi, R Luciani, H Myllykallio, ...
2011
Crystal Structure of histidine-tagged human thymidylate synthase
C Pozzi, D Cardinale, G Guaitoli, D Tondi, R Luciani, H Myllykallio, ...
2011
Tethering low affinity ligands to the dimeric interface of human thymidylate synthase.
MP Costi, F Genovese, S Franchini, A Venturelli, S Lazzari, DSF Farina, ...
XX National Meeting on Medicinal Chemistry, 58-59, 2010
2010
Allosteric Inhibition of human Thymidylate Synthase.
S Henrich, O Salo Ahen, D Garg, D Cardinale, S Ferrari, S Franchini, ...
Biomolecular Interaction Networks: Function and Disease., ...-..., 2010
2010
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Artikkelit 1–20