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Uthpla Seneviratne
Uthpla Seneviratne
Principal Scientist, Pfizer
Verified email at mit.edu - Homepage
Title
Cited by
Cited by
Year
Protein-retention expansion microscopy of cells and tissues labeled using standard fluorescent proteins and antibodies
PW Tillberg, F Chen, KD Piatkevich, Y Zhao, CC Yu, BP English, L Gao, ...
Nature biotechnology 34 (9), 987-992, 2016
5562016
S-nitrosation of proteins relevant to Alzheimer’s disease during early stages of neurodegeneration
U Seneviratne, A Nott, VB Bhat, KC Ravindra, JS Wishnok, LH Tsai, ...
Proceedings of the National Academy of Sciences 113 (15), 4152-4157, 2016
992016
PF-06651600, a dual JAK3/TEC family kinase inhibitor
H Xu, MI Jesson, UI Seneviratne, TH Lin, MN Sharif, L Xue, C Nguyen, ...
ACS chemical biology 14 (6), 1235-1242, 2019
822019
Cytotoxic and Pathogenic Properties of Klebsiella oxytoca Isolated from Laboratory Animals
JGF Alison Darby, Kvin Lertpiriyapong, Ujjal Sarkar, Uthpala Seneviratne ...
PloS one, e100542, 2014
722014
Mechanism-based triarylphosphine-ester probes for capture of endogenous RSNOs
U Seneviratne, LC Godoy, JS Wishnok, GN Wogan, SR Tannenbaum
Journal of the American Chemical Society 135 (20), 7693-7704, 2013
652013
Exocyclic deoxyadenosine adducts of 1, 2, 3, 4-diepoxybutane: synthesis, structural elucidation, and mechanistic studies
U Seneviratne, S Antsypovich, M Goggin, DQ Dorr, R Guza, A Moser, ...
Chemical research in toxicology 23 (1), 118-133, 2010
502010
Global portrait of protein targets of metabolites of the neurotoxic compound BIA 10–2474
Z Huang, D Ogasawara, UI Seneviratne, AB Cognetta III, CW Am Ende, ...
ACS chemical biology 14 (2), 192-197, 2019
462019
Mapping the binding site of BMS-708163 on γ-secretase with cleavable photoprobes
N Gertsik, CW Am Ende, KF Geoghegan, C Nguyen, P Mukherjee, ...
Cell chemical biology 24 (1), 3-8, 2017
372017
Dual-Reactivity trans-Cyclooctenol Probes for Sulfenylation in Live Cells Enable Temporal Control via Bioorthogonal Quenching
SL Scinto, O Ekanayake, U Seneviratne, JE Pigga, SJ Boyd, MT Taylor, ...
Journal of the American Chemical Society 141 (28), 10932-10937, 2019
342019
Column Switching HPLC-ESI+-MS/MS Methods for Quantitative Analysis of Exocyclic dA Adducts in the DNA of Laboratory Animals Exposed to 1,3-Butadiene
M Goggin, U Seneviratne, JA Swenberg, VE Walker, N Tretyakova
Chemical research in toxicology 23 (4), 808-812, 2010
302010
SRSF1 and PTBP1 are trans-acting factors that suppress the formation of a CD33 splicing isoform linked to Alzheimer's disease risk
HSA van Bergeijk P, Seneviratne U, Aparicio-Prat E, Stanton R
Molecular Cell Biology, 2019
262019
Translesion synthesis across 1, N6-(2-hydroxy-3-hydroxymethylpropan-1, 3-diyl)-2′-deoxyadenosine (1, N6-γ-HMHP-dA) adducts by human and archebacterial DNA polymerases
S Kotapati, L Maddukuri, S Wickramaratne, U Seneviratne, M Goggin, ...
Journal of Biological Chemistry 287 (46), 38800-38811, 2012
242012
Dipyridamole inhibits lipogenic gene expression by retaining SCAP-SREBP in the endoplasmic reticulum
RM Esquejo, M Roqueta-Rivera, W Shao, PE Phelan, U Seneviratne, ...
Cell chemical biology 28 (2), 169-179. e7, 2021
172021
Photoaffinity labeling and quantitative chemical proteomics identify LXRβ as the functional target of enhancers of astrocytic apoE
U Seneviratne, Z Huang, CW Am Ende, TW Butler, L Cleary, ...
Cell Chemical Biology 28 (2), 148-157. e7, 2021
162021
Transimination of quinone imines: a mechanism for embedding exogenous redox activity into the nucleosome
W Ye, UI Seneviratne, MW Chao, KC Ravindra, GN Wogan, ...
Chemical Research in Toxicology 25 (12), 2627-2629, 2012
152012
Mass Spectrometry Based Approach to Study the Kinetics of O6-Alkylguanine DNA Alkyltransferase-Mediated Repair of O6-Pyridyloxobutyl-2 …
D Kotandeniya, D Murphy, U Seneviratne, R Guza, A Pegg, S Kanugula, ...
Chemical research in toxicology 24 (11), 1966-1975, 2011
142011
DNA oligomers containing site-specific and stereospecific exocyclic deoxyadenosine adducts of 1, 2, 3, 4-diepoxybutane: Synthesis, characterization, and effects on DNA structure
U Seneviratne, S Antsypovich, DQ Dorr, T Dissanayake, S Kotapati, ...
Chemical research in toxicology 23 (10), 1556-1567, 2010
142010
Kinetics of O6-Pyridyloxobutyl-2′-deoxyguanosine Repair by Human O6-alkylguanine DNA Alkyltransferase
D Kotandeniya, D Murphy, S Yan, S Park, U Seneviratne, ...
Biochemistry 52 (23), 4075-4088, 2013
122013
Structures of Exocyclic R,R- and S,S-N6,N6-(2,3-Dihydroxybutan-1,4-diyl)-2′-Deoxyadenosine Adducts Induced by 1,2,3,4-Diepoxybutane
EA Kowal, U Seneviratne, S Wickramaratne, KE Doherty, X Cao, ...
Chemical research in toxicology 27 (5), 805-817, 2014
112014
1,3-Butadiene-Induced Adenine DNA Adducts Are Genotoxic but Only Weakly Mutagenic When Replicated in Escherichia coli of Various Repair and Replication …
S Chang, UI Seneviratne, J Wu, N Tretyakova, JM Essigmann
Chemical research in toxicology 30 (5), 1230-1239, 2017
82017
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